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Akademický článek

Effects of anti-inflammatory drugs on fever and neutrophilia induced by Clostridium difficile toxin B

Autor: R. A. Cardoso, A. A. Melo Filho, M. C. C. Melo, D. M. Lyerly, T. D. Wilkins, A. A. M. Lima, R. A. Ribeiro, G. E. P. Souza

Publikováno v: Mediators of Inflammation, Vol 5, Iss 3, Pp 183-187 (1996)

This study investigated the ability of Clostridium difficile toxin B, isolated from the VPI 10463 strain, to induce fever and neutrophilia in rats. Intravenous injection of toxin B (0.005–0.5 μg/kg) evoked a dose-dependent increase in body tempera

Externí odkaz: https://doaj.org/article/25e18328760a4675a6b67a97a49816fc

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Triazol-phenyl Antipyretic Derivatives Inhibit mPGES-1 mRNA Levels in LPS-Induced RAW 264.7 Macrophage Cells

Autor: M. C. C. Melo, Denis Melo Soares, Marcelo Santos Castilho, Lenisa Dandara Dos Santos, Glória Emília Petto de Souza, Thamires Quadros Froes

Publikováno v: Anti-inflammatoryanti-allergy agents in medicinal chemistry. 20(3)

Background: Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the terminal step of prostaglandin E2 (PGE2) production, which plays an important role in the regulation of febrile response. In our previous work, ligand-based pharmacophore model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97cdf50e94918d9c26a0c3cad960275e
https://pubmed.ncbi.nlm.nih.gov/33292158

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Akademický článek

A pre-formed Pyrogenic Factor Released by Lipopolysaccharide Stimulated Macrophages

Autor: A. R. Zampronio, M. C. C. Melo, C. A. A. Silva, I. R. Pelá, S. J. Hopkins, G. E. P. Souza

Publikováno v: Mediators of Inflammation, Vol 3, Iss 5, Pp 365-373 (1994)

The aim of this study was to investigate the pyrogenic activity of factor(s) released by rat peritoneal macrophages following a brief stimulation with LPS. The effect of this factor on the number of circulating leukocytes and serum Fe, Cu and Zn leve

Externí odkaz: https://doaj.org/article/1f54607117fb4929a2a476f73a6ccb8e

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The relevance of kalikrein-kinin system via activation of B2 receptor in LPS-induced fever in rats

Autor: Christoph Rummel, Danielle R. Santos, Denis Melo Soares, Glória Emília Petto de Souza, M. C. C. Melo, João B. Calixto, Joachim Roth, Daniela Ott

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Purpose This study evaluated the involvement of endogenous kallikrein-kinin system and the bradykinin (BK) B 1 and B 2 receptors on LPS- induced fever and the POA cells involved in this response. Material and methods Male Wistar rats received either

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d11686fc865b5e24af27537720a347d

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Chemokine ligand (CCL)-3 promotes an integrated febrile response when injected within pre-optic area (POA) of rats and induces calcium signaling in cells of POA microcultures but not TNF-α or IL-6 synthesis

Autor: Denis Melo Soares, M. C. C. Melo, Daniela Ott, Joachim Roth, Glória Emília Petto de Souza

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Although studies have shown that chemokines are pyrogenic when injected into the brain, there are no data indicating which cell types and receptors in the CNS are employed by chemokines such as CCL3 (synonym: MIP-1α) to induce fever in rats. We aime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c7f87df1a09425dd90b610d8b02608
https://pubmed.ncbi.nlm.nih.gov/23999490

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Increase of core temperature induced by corticotropin-releasing factor and urocortin: a comparative study

Autor: M. C. C. Melo, Maria José Figueiredo, Aline S.C. Fabricio, Renes R. Machado, Glória Emília Petto de Souza, Denis Melo Soares

Publikováno v: Regulatory peptides. 165(2-3)

This study compared the ability of CRF and UCN1 to induce a thermoregulatory response when centrally injected into rats. The effects of antipyretic drugs and CRF receptor antagonists (CRF₁ and CRF₂) on the temperature (T) changes induced by these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7346190284c9ac037fc4a738612120
https://pubmed.ncbi.nlm.nih.gov/20691217

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Importance of the vagus nerve for fever and neutrophil migration induced by intraperitoneal LPS injection

Autor: Aleksander Roberto Zampronio, Maria Fernanda de Paula Werner, Daniel Fraga, G E P Souza, M. C. C. Melo

Publikováno v: Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 52(7)

Objective: We investigated the importance of the vagus nerve in fever, neutrophil migration and neutrophilia simultaneously induced by intraperitoneal injection of endotoxin (lipopolysaccharide, LPS) and in terms of the production of pre-formed pyrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdafa9f75b152dee8ddb83d0bbe11a8
https://pubmed.ncbi.nlm.nih.gov/12861394

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A comparative study of the antipyretic effects of indomethacin and dipyrone in rats

Autor: Rafael Cardoso, Aleksander Roberto Zampronio, V. M. S. Silva, Giles A. Rae, Aline S.C. Fabricio, M. Lora, G. E. P. de Souza, Sindynara Ferreira, M. C. C. Melo, A.J. de Brum-Fernandes

Publikováno v: Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 51(1)

Objective: Compare the antipyretic effects of dipyrone and indomethacin.¶Materials and methods: Fever was induced in rats by i.v. LPS or i.c.v. interleukins (IL), prostaglandins (PG), arachidonic acid (AA), pre-formed pyrogenic factor (PFPF), tumour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3f116d79e728b3d800d9cd7b9773fb
https://pubmed.ncbi.nlm.nih.gov/11852909

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Involvement of CRH in fever induced by a distinct pre-formed pyrogenic factor (PFPF)

Autor: G E P Souza, A. R. Zampronio, M. C. C. Melo, S.J. Hopkins

Publikováno v: Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 49(9)

Objective: This study investigated the role of corticotrophin-releasing hormone (CRH) in mediating the fever induced by a novel pre-formed pyrogenic factor (PFPF), using a CRF antagonist in vivo and evaluating the capacity of PFPF to stimulate CRH re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254e044ca8e2be12dd8de46fbacb6f15
https://pubmed.ncbi.nlm.nih.gov/11071122

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A pre-formed Pyrogenic Factor Released by Lipopolysaccharide Stimulated Macrophages

Autor: Carlos A. Silva, A. R. Zampronio, G E P Souza, M C C Melo, Stephen J. Hopkins, I R Pela

Publikováno v: Mediators of Inflammation
Mediators of Inflammation, Vol 3, Iss 5, Pp 365-373 (1994)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd19816a232d6671e152c59362fe4a2
https://pubmed.ncbi.nlm.nih.gov/18475582

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