Zobrazeno 1 - 10
of 29
pro vyhledávání: '"M C, Udey"'
Publikováno v:
The Journal of Immunology. 159:2693-2701
Langerhans cells (LC), the epidermal contingent of the dendritic cell (DC) lineage, migrate from skin to regional lymph nodes to initiate primary immune responses against Ag encountered in skin. Because E-cadherin mediates LC-keratinocyte adhesion, E
Publikováno v:
The Journal of Immunology. 152:5653-5659
Cadherins mediate homotypic adhesion between lineage-related cells in epithelia and other tissues. One cadherin, E-cadherin, is also responsible for adhesion of murine epidermal Langerhans cells to keratinocytes in vitro, and may play a role in the l
Publikováno v:
Methods in molecular medicine. 64
The dendritic cell (DC) lineage is comprised of bone marrow-derived cells that are present in small numbers in nonlymphoid as well as lymphoid tissues (1). Nonlymphoid DC, such as epidermal Langerhans cells (LC), display an immature phenotype, i.e.,
Publikováno v:
The Journal of Immunology. 151:2390-2398
IL-10 is a product of activated keratinocytes and is released during the induction phase of contact sensitivity. As IL-10 effects have been described as being mediated by APC, we investigated effects of IL-10 on epidermal Langerhans cells (LC), the r
Publikováno v:
The Journal of Immunology. 150:3698-3704
Langerhans cells (LC) are Ag-presenting cells required for induction of primary immune responses in skin. After activation by Ag, LC express increased levels of MHC class II Ag, exhibit increased accessory cell activity, and migrate to regional lymph
Publikováno v:
The Journal of Immunology. 146:3347-3355
Immunosuppressive effects of low levels of ultraviolet B (UVB) radiation on cutaneous immune responses have been attributed to deleterious effects of UVB radiation on epidermal Langerhans cells (LC). To determine how UVB radiation modulates LC functi
Publikováno v:
European journal of immunology. 30(12)
Leishmania major-infected C57BL / 6 skin-dendritic cells (DC) are activated and release cytokines (including IL-12 p70), and likely initiate protective Th1 immunity in vivo (von Stebut, E. et al., J. Exp. Med. 188: 1547 - 1552). To characterize diffe
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(6)
Genetic vaccination depends at least in part on the adjuvant properties of plasmids, properties that have been ascribed to unmethylated CpG dinucleotides in bacterial DNA. Because dendritic cells (DC) participate in the T cell priming that occurs dur
Autor:
E W, Shores, M, Ono, T, Kawabe, C L, Sommers, T, Tran, K, Lui, M C, Udey, J, Ravetch, P E, Love
Publikováno v:
The Journal of Experimental Medicine
The zeta family includes zeta, eta, and FcepsilonRIgamma (Fcgamma). Dimers of the zeta family proteins function as signal transducing subunits of the T cell antigen receptor (TCR), the pre-TCR, and a subset of Fc receptors. In mice lacking zeta/eta c
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(8)
Adhesion of Langerhans cells (LC) to keratinocytes is mediated by E-cadherin. IL-1, TNF-alpha, and LPS mobilize LC from epidermis and presumably attenuate LC-keratinocyte adhesion. To determine whether these mediators modulated LC E-cadherin-dependen