Výsledky vyhledávání - "M C, Shoshan"

A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera

Autor: K, Bivén, H, Erdal, M, Hägg, T, Ueno, R, Zhou, M, Lynch, B, Rowley, J, Wood, C, Zhang, M, Toi, M C, Shoshan, S, Linder

Publikováno v: Apoptosis : an international journal on programmed cell death. 8(3)

We have developed an apoptosis assay based on measurement of a neoepitope of cytokeratin-18 (CK18-Asp396) exposed after caspase-cleavage and detected by the monoclonal antibody M30. The total amount of caspase-cleaved CK18 which has accumulated in ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c16fadac9c831e0bc750f7f10819b51f
https://pubmed.ncbi.nlm.nih.gov/12766486

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Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin

Autor: K, Viktorsson, T, Heiden, M, Molin, G, Akusjärvi, S, Linder, M C, Shoshan

Publikováno v: Apoptosis : an international journal on programmed cell death. 5(4)

Mutationally activated Ras is involved in tumor progression and likely also in drug resistance. Using survival, viability and apoptosis assays, we have here compared the cisplatin sensitivities of FR3T3 rat fibroblasts and a 12V-H-ras transformed sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2cff083e75d14e3135f624946f29af64
https://pubmed.ncbi.nlm.nih.gov/11227217

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ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation

Autor: M, Seddighzadeh, J N, Zhou, U, Kronenwett, M C, Shoshan, G, Auer, M, Sten-Linder, B, Wiman, S, Linder

Publikováno v: Clinicalexperimental metastasis. 17(8)

Increased urokinase plasminogen activator (u-PA) production is associated with tumor invasion and metastasis in several malignancies, including breast cancer. The mechanisms underlying constitutive u-PA expression are not well understood. We examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c584cfef99baf2733e7eee2389e8c6f1
https://pubmed.ncbi.nlm.nih.gov/10919709

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Down-regulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop

Autor: S, Ljungdahl, S, Linder, B, Franzén, B, Binétruy, G, Auer, M C, Shoshan

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 9(7)

Overexpression of the c-Jun transcription factor in rodent fibroblasts may result in cell transformation or in apoptosis. The mechanisms whereby c-Jun induces transformation are unknown. We show here that the expression of high-molecular weight tropo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a813dd35ec0fc144a71085c12b555f11
https://pubmed.ncbi.nlm.nih.gov/9690624

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Codeletion of the JUN proto-oncogene and the CDKN2A tumor-suppressor gene in HRAS-transformed rat embryo fibroblast cell lines

Autor: J N, Zhou, S, Ljungdahl, D, Röhme, G, Levan, M C, Shoshan, S, Linder

Publikováno v: Genes, chromosomescancer. 20(1)

The cyclin kinase inhibitor p16, encoded by the CDKN2A gene, suppresses the transformation of mouse embryonic fibroblasts by oncogenic RAS. In contrast, the c-JUN transcription factor (a major component of AP-1) has been suggested to be required for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d168b1d0d6b3a44f60ca121bcc26a9a
https://pubmed.ncbi.nlm.nih.gov/9290958

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The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line

Autor: T, Fokstuen, Y B, Rabo, J N, Zhou, J, Karlson, A, Platz, M C, Shoshan, J, Hansson, S, Linder

Publikováno v: Anticancer research. 17(4A)

Ras proteins have been implicated in transducing cellular responses to DNA damaging agents. We used BZA-5B, an inhibitor of Ras-farnesylation, to examine the role of Ras in cellular sensitivity to cisplatin. A human melanoma cell line (224) with a Gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4db81edaa8abbef39abb2483cffcf05f
https://pubmed.ncbi.nlm.nih.gov/9252645

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Different mechanisms are responsible for c-jun mRNA induction by cisplatin and ultraviolet light

Autor: Y B, Rabo, M C, Shoshan, S, Linder, J, Hansson

Publikováno v: International journal of cancer. 65(6)

Ultraviolet light (UV) and different DNA-damaging agents are known to induce AP-l-transcription-factor activity. Whereas UV induction appears to be triggered by events at the cell membrane, the mechanism of AP-l activation by alkylating or platinatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f786411dc81b516db6ed46fca056583
https://pubmed.ncbi.nlm.nih.gov/8631598

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Microfilament-disrupting Clostridium difficile toxin B causes multinucleation of transformed cells but does not block capping of membrane Ig

Autor: M C, Shoshan, P, Aman, S, Skog, I, Florin, M, Thelestam

Publikováno v: European journal of cell biology. 53(2)

The effects of Clostridium difficile toxin B on some actin-dependent cellular functions were studied. A three-day incubation of intoxicated B-lymphocytes and transformed 3T3 fibroblasts resulted in dose-dependent multinucleation. Using vimentin-negat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92e02608d427e30516f5dc1ac0f030dc
https://pubmed.ncbi.nlm.nih.gov/2081549

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