Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk

Autor: S. I. Dimitriadis, G. Perry, S. F. Foley, K. E. Tansey, D. K. Jones, P. Holmans, S. Zammit, J. Hall, M. C. O’Donovan, M. J. Owen, K. D. Singh, D. E. Linden

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)

Abstract Gamma oscillations (30–90 Hz) have been proposed as a signature of cortical visual information processing, particularly the balance between excitation and inhibition, and as a biomarker of neuropsychiatric diseases. Magnetoencephalography

Externí odkaz: https://doaj.org/article/04d7fcdfd1884d62becdc5bcbe76590d

Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: Evidence from population sample stratified for polygenic risk

Autor: S I Dimitriadis, G Perry, T M Lancaster, K E Tansey, K D Singh, P Holmans, A Pocklington, G Davey Smith, S Zammit, J Hall, M C O’Donovan, M J Owen, D K Jones, D E Linden

Publikováno v: Cerebral Cortex, 33:bhac256, 2997-3011. Oxford University Press
Dimitriadis, S L, Perry, G, Lancaster, T, Tansey, K, Singh, K D, Holmans, P, Pocklington, A, Davey Smith, G, Zammit, S, Hall, J, O'Donovan, M C, Owen, MJ, Jones, D K & Linden, DE 2022, ' Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis : Evidence from population sample stratified for polygenic risk ', Cerebral Cortex . https://doi.org/10.1093/cercor/bhac256

Research studies based on tractography have revealed a prominent reduction of asymmetry in some key white-matter tracts in schizophrenia (SCZ). However, we know little about the influence of common genetic risk factors for SCZ on the efficiency of ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfa0fe20520b86b5351b76d5506a230

Schizophrenia copy number variants and associative learning

Autor: N E, Clifton, A J, Pocklington, B, Scholz, E, Rees, J T R, Walters, G, Kirov, M C, O'Donovan, M J, Owen, L S, Wilkinson, K L, Thomas, J, Hall

Publikováno v: Molecular Psychiatry

Large-scale genomic studies have made major progress in identifying genetic risk variants for schizophrenia. A key finding from these studies is that there is an increased burden of genomic copy number variants (CNVs) in schizophrenia cases compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5be5155d1c20db17b68a7e04a2ca8a4
https://pubmed.ncbi.nlm.nih.gov/27956746

Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes.

Autor: Maury, Eduardo A.^1,2,3, Jones, Attila^4,5, Seplyarskiy, Vladimir^6,7, Nguyen, Thanh Thanh L.^8,9, Rosenbluh, Chaggai⁵, Taejong Bae¹⁰, Yifan Wang¹⁰, Abyzov, Alexej¹⁰, Khoshkhoo, Sattar^2,11, Chahine, Yasmine^1,11, Sijing Zhao², Venkatesh, Sanan⁴, Root, Elise⁹, Voloudakis, Georgios¹², Roussos, Panagiotis¹², Park, Peter J.⁷, Akbarian, Schahram^13,14, Brennand, Kristen^8,9, Reilly, Steven⁹, Lee, Eunjung A.^1,2

Publikováno v: Science. 10/11/2024, Vol. 386 Issue 6718, p217-224. 8p. 5 Color Photographs.

Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization.

Autor: Ni T; Key Laboratory of National Health Commission for Forensic Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.; Institute of Neuroscience, Bio-evidence Sciences Academy, Xi'an Jiaotong University Health Science Center, Xi'an, 712046, China., Sun Y; Department of Endocrinology and Metabolism, Qilu Hospital of Shandong University, Ji'nan, 250000, China., Li Z; Key Laboratory of National Health Commission for Forensic Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China., Tan T; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, 325603, China., Han W; Key Laboratory of National Health Commission for Forensic Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.; Institute of Neuroscience, Bio-evidence Sciences Academy, Xi'an Jiaotong University Health Science Center, Xi'an, 712046, China., Li M; Department of Ultrasound, the Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710004, China., Zhu L; Key Laboratory of National Health Commission for Forensic Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.; Institute of Neuroscience, Bio-evidence Sciences Academy, Xi'an Jiaotong University Health Science Center, Xi'an, 712046, China., Xiao J; Key Laboratory of National Health Commission for Forensic Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.; Institute of Neuroscience, Bio-evidence Sciences Academy, Xi'an Jiaotong University Health Science Center, Xi'an, 712046, China., Wang H; Key Laboratory of National Health Commission for Forensic Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.; Institute of Neuroscience, Bio-evidence Sciences Academy, Xi'an Jiaotong University Health Science Center, Xi'an, 712046, China., Zhang W; Key Laboratory of National Health Commission for Forensic Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.; Institute of Neuroscience, Bio-evidence Sciences Academy, Xi'an Jiaotong University Health Science Center, Xi'an, 712046, China., Ma Y; Key Laboratory of National Health Commission for Forensic Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.; Institute of Neuroscience, Bio-evidence Sciences Academy, Xi'an Jiaotong University Health Science Center, Xi'an, 712046, China., Wang B; Department of Immunology and Pathogenic Biology, College of Basic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China., Wen D; College of Forensic Medicine, Hebei Key Laboratory of Forensic Medicine, Hebei Medical University, Shijiazhuang, 050017, China., Chen T; Key Laboratory of National Health Commission for Forensic Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.; Institute of Neuroscience, Bio-evidence Sciences Academy, Xi'an Jiaotong University Health Science Center, Xi'an, 712046, China., Tubbs J; Department of Psychiatry, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, 999077, China., Zeng X; Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, 650500, China., Yan J; Department of Genetics, School of Medicine & Forensics, Shanxi Medical University, Taiyuan, 030009, China., Gui H; Behavioral Health Services and Psychiatry Research, Henry Ford Health, Detroit, MI, 48202, USA.; Department of Psychiatry, Michigan State University, East Lansing, MI, 48824, USA., Sham P; Department of Psychiatry, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, 999077, China., Guan F; Key Laboratory of National Health Commission for Forensic Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.; Institute of Neuroscience, Bio-evidence Sciences Academy, Xi'an Jiaotong University Health Science Center, Xi'an, 712046, China.; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, 325603, China.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Nov 20, pp. e2407628. Date of Electronic Publication: 2024 Nov 20.