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Comparison of two regimens for the treatment of elderly patients with acute lymphoblastic leukaemia (ALL)

Autor: Pietro Leoni, M C Masia, Lara Malerba, Massimo Catarini, Monica Marconi, Riccardo Centurioni, Laura Corvatta, Massimo Offidani, Franco Leoni, Anna Rita Scortechini

Publikováno v: Leukemia & Lymphoma. 46:233-238

Acute lymphoblastic leukemia (ALL) represents a rare malignancy in the elderly and few authors have specifically focused on the treatment of ALL in this setting. We recently published the results of a prospective phase II study comprising an inductio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4007acc18caf05e2bf377f394c62511
https://doi.org/10.1080/10428190400019917

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Combined administration of alpha-erythropoietin and filgrastim can improve the outcome and cost balance of autologous stem cell transplantation in patients with lymphoproliferative disorders

Autor: Pietro Leoni, M C Masia, Guido Gini, GianMario Raggetti, M Troiani, Massimo Offidani, M Montanari, Antonella Poloni, Attilio Olivieri, Debora Capelli, Ilaria Scortechini, Moira Lucesole

Publikováno v: Bone Marrow Transplantation. 34:693-702

We compared the use of G-CSF plus EPO in a group of 32 multiple myeloma and lymphoma patients with historical controls receiving G-CSF alone. Haemopoietic reconstitution was significantly faster in patients receiving G-CSF+EPO (group B), with a media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dc1ea9c99de470a55bfeab7e0e658a
https://doi.org/10.1038/sj.bmt.1704643

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Very low toxicity and good quality of life in 48 elderly patients autotransplanted for hematological malignancies: a single center experience

Autor: M Montanari, P. Leoni, Debora Capelli, Antonella Poloni, Riccardo Centurioni, Marco Candela, Attilio Olivieri, Danilo Massidda, C Tonnini, M C Masia, Marino Brunori, Moira Lucesole

Publikováno v: Bone Marrow Transplantation. 27:1189-1195

Between May 1994 and May 2000, we autotransplanted 48 consecutive patients, 21 females and 27 males aged over 60 years (range: 60-78, median: 63). Sixteen patients had multiple myeloma (MM), 14 high-grade non-Hodgkin's lymphoma (HGNHL), six low-grade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94ceef4c999985ecd81b02d8f31bbe2
https://doi.org/10.1038/sj.bmt.1703034

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Ex vivo pharmacological purging of leukapheresis collections with nitrogen mustard

Autor: M Montanari, Antonella Poloni, Cantori I, Attilio Olivieri, Stefania Mancini, Pietro Leoni, Laura Curzi, M C Masia

Publikováno v: Experimental Hematology. 27:1548-1556

Ex vivo pharmacological purging of bone marrow has been used to eliminate clonogenic tumor cells contaminating the autograft and potentially responsible of relapse. A considerable improvement of pharmacological purging would be achieved only if norma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa188499d3062aa64cc393359e28bc55
https://doi.org/10.1016/s0301-472x(99)00086-7

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Engraftment capacity of mesenchymal cells following hematopoietic stem cell transplantation in patients receiving reduced-intensity conditioning regimen

Autor: Attilio Olivieri, Loredana Buscemi, R Pasquini, M C Masia, E Costantino, Nadia Viola, F Balducci, Giancarlo Discepoli, Adriano Tagliabracci, Antonella Poloni, Paolo Corradini, P. Leoni

Publikováno v: Leukemia. 20(2)

The engraftment ability of mesenchymal cells was investigated in 26 patients receiving allogeneic transplantation from HLA-identical siblings with reduced-intensity conditioning (RIC). The stem cell source was bone marrow (BM) in eight patients and G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb4e6e9ed87155881cc2bb9391ca8d4
https://pubmed.ncbi.nlm.nih.gov/16341047

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Ex vivo pharmacological purging of leukapheresis collections with nitrogen mustard: amifostine pretreatment improves both early and late peripheral blood progenitor cell recovery

Autor: A, Poloni, P, Leoni, L, Curzi, I, Cantori, S, Mancini, M, Montanari, M C, Masia, A, Olivieri

Publikováno v: Experimental hematology. 27(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3fdb8573a7538996b528a709192e2165
https://pubmed.ncbi.nlm.nih.gov/10517497

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Direct demonstration of cytokeratin filaments by electron microscopy in K562 cell lines in liquid culture

Autor: S, Mancini, A, Olivieri, M C, Masia, L, Ombrosi, M, Montanari, S, Rupoli, L, Curzi, M, Morroni, S, Sisti, P, Leoni

Publikováno v: Bollettino della Societa italiana di biologia sperimentale. 73(5-6)

Our previous study suggested the presence of cytokeratins in the supernatant of human K562 erythroleukemic cell line. In this study we confirm, by using an electron microscopy technique, that K562 cells contain typical intermediate tonofilaments with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d74c89e882da1da63cafb4086c07081
https://pubmed.ncbi.nlm.nih.gov/9796125

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Pharmacologic bone marrow purging: is there any place for etoposide? In vitro comparison with mafosfamide

Autor: M Montanari, Stefania Mancini, Pietro Leoni, Cantori I, M C Masia, L. Curzi, Attilio Olivieri, Antonella Poloni, Laura Corvatta

Publikováno v: Journal of hematotherapy. 6(2)

Residual leukemic cells in a bone marrow graft may increase the risk of relapse after autotransplantation. We have compared the efficacy of etoposide with that of mafosfamide, which has been used mainly for purging in acute leukemias. First, we exami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3819431ef162eda3d8ad941a20962c3
https://pubmed.ncbi.nlm.nih.gov/9131443

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Addition of erythropoietin to granulocyte colony-stimulating factor after priming chemotherapy enhances hemopoietic progenitor mobilization

Autor: A, Olivieri, M, Offidani, I, Cantori, L, Ciniero, L, Ombrosi, M C, Masia, M, Brunori, M, Montroni, P, Leoni

Publikováno v: Bone marrow transplantation. 16(6)

Hemopoietic progenitor cell mobilization intended for autotransplantation is now feasible in many patients, following the administration of single cytokines (G-CSF, GM-CSF, IL-3) or their combination. Erythropoietin (EPO) is a cytokine which showed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74bf7879edbb44d18c938b1105e4f704
https://pubmed.ncbi.nlm.nih.gov/8750267

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DHAP regimen plus G-CSF as salvage therapy and priming for blood progenitor cell collection in patients with poor prognosis lymphoma

Autor: A, Olivieri, M, Offidani, L, Ciniero, I, Cantori, L, Ombrosi, S, Mancini, M C, Masia, P, Scalari, P, Leoni

Publikováno v: Bone marrow transplantation. 16(1)

We studied 14 patients affected by lymphoma to assess the toxicity, efficacy and mobilization capability of salvage DHAP regimen followed by G-CSF 5 micrograms/kg/day. Ten patients were affected by intermediate-grade NHL and 4 by HD; all of them were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af349ef3036b65df1c88479fa43c8497
https://pubmed.ncbi.nlm.nih.gov/7581135

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