Výsledky vyhledávání - "M C, Levesque"

Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13

Autor: M C Levesque, B F Haynes

Publikováno v: The Journal of Immunology. 159:6184-6194

Ligation of CD44 by hyaluronan (HA) is a key proinflammatory event that regulates lymphocyte and monocyte adhesion and cytokine production. While most immune cells express CD44, few immune cells constitutively bind HA. We have previously shown that m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::912ac3b7f3778142717b507f6598ddd6
https://doi.org/10.4049/jimmunol.159.12.6184

Zobrazit plný text záznamu

In vitro culture of human peripheral blood monocytes induces hyaluronan binding and up-regulates monocyte variant CD44 isoform expression

Autor: M C Levesque, B F Haynes

Publikováno v: The Journal of Immunology. 156:1557-1565

CD44 is a cell surface proteoglycan homologous to cartilage link protein that serves as a receptor for hyaluronan (HA). CD44 isoforms include an unspliced 80- to 90-kDa standard form (CD44S) and isoforms derived from alternative splicing of nine CD44

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::210bb03a1c64a525cb924b29eff69e6e
https://doi.org/10.4049/jimmunol.156.4.1557

Zobrazit plný text záznamu

N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding

Autor: H X Liao, D M Lee, M C Levesque, B F Haynes

Publikováno v: The Journal of Immunology. 155:3938-3945

CD44 molecules are cell surface receptors for hyaluronan (HA). To define regions of the extracellular domain of CD44 that are important for HA binding, we have studied the ability of HA-blocking CD44 mAbs to bind to CD44 from a variety of sources. Fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b6353969808e0d42bb12464e246767d
https://doi.org/10.4049/jimmunol.155.8.3938

Zobrazit plný text záznamu

Translational Mini-Review Series on B Cell-Directed Therapies: Recent advances in B cell-directed biological therapies for autoimmune disorders

Autor: M C Levesque

Publikováno v: Clinical and experimental immunology. 157(2)

Summary B cell-directed therapies are promising treatments for autoimmune disorders. Besides targeting CD20, newer B cell-directed therapies are in development that target other B cell surface molecules and differentiation factors. An increasing numb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e7ed7191e3b0095e2f0b459b15624a
https://pubmed.ncbi.nlm.nih.gov/19604259

Zobrazit plný text záznamu

Serum levels of soluble CD44 in primary Sjögren's syndrome

Autor: M C, Levesque, D A, Mackin, J A, Fleming, E W, St Clair

Publikováno v: The Journal of rheumatology. 27(6)

To determine whether elevated soluble CD44 (sCD44) levels serve as a marker of inflammation and lymphoproliferation in primary Sjögren's syndrome (SS).We measured sCD44 levels by ELISA in serum samples from a cross section of healthy individuals and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::858fac355a419072c8d69102aec8ddb3
https://pubmed.ncbi.nlm.nih.gov/10852268

Zobrazit plný text záznamu

Interferon-beta1A-induced polyarthritis in a patient with the HLA-DRB1*0404 allele

Autor: M C, Levesque, F E, Ward, D R, Jeffery, J B, Weinberg

Publikováno v: Arthritis and rheumatism. 42(3)

Human interferon-alpha (IFNalpha) and IFNbeta are administered for treatment of several diseases, including viral infections, malignancies, and multiple sclerosis (MS). IFNalpha therapy has been associated with the production of autoantibodies and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd1bcb948511e583f50c40f9be1bf691
https://pubmed.ncbi.nlm.nih.gov/10817580

Zobrazit plný text záznamu

Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid arthritis synovium

Autor: M C, Levesque, C S, Heinly, L P, Whichard, D D, Patel

Publikováno v: Arthritis and rheumatism. 41(12)

To determine whether monocyte/macrophage expression of the CD6 ligand, activated leukocyte cell adhesion molecule (ALCAM) (CD166), is regulated by cytokines during inflammation in rheumatoid arthritis (RA).We used flow cytometry to test whether cytok

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d22795806f82ff642a41f9fe083135f1
https://pubmed.ncbi.nlm.nih.gov/9870879

Zobrazit plný text záznamu

Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13

Autor: M C, Levesque, B F, Haynes

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9121f668d5f96aea9afd434c280c718f
https://pubmed.ncbi.nlm.nih.gov/9550421

Zobrazit plný text záznamu

Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells

Autor: N P, Liu, W L, Roberts, L P, Hale, M C, Levesque, D D, Patel, C L, Lu, G J, Jaffe

Publikováno v: Investigative ophthalmologyvisual science. 38(10)

CD44 is a major hyaluronic acid receptor that exists as a number of isoforms, generated by alternative splicing of 9 "variant" exons in humans (v2 to v10) and 10 exons in rodents. Little is known about the expression and function of CD44 in human ret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7375c2a4e6ed9538340bd32cc95c3b5d
https://pubmed.ncbi.nlm.nih.gov/9331266

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání