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Akademický článek

A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations.

Autor: Jin Ou, Eric M Lewandowski, Yanmei Hu, Austin A Lipinski, Ali Aljasser, Mariliz Colon-Ascanio, Ryan T Morgan, Lian M C Jacobs, Xiujun Zhang, Melissa J Bikowitz, Paul R Langlais, Haozhou Tan, Jun Wang, Yu Chen, John S Choy

Publikováno v: PLoS Pathogens, Vol 19, Iss 8, p e1011592 (2023)

The SARS-CoV-2 main protease (Mpro) is a major therapeutic target. The Mpro inhibitor, nirmatrelvir, is the antiviral component of Paxlovid, an orally available treatment for COVID-19. As Mpro inhibitor use increases, drug resistant mutations will li

Externí odkaz: https://doaj.org/article/39ca587144e144418e7e1eb6c544ee20

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Akademický článek

Deep versus moderate neuromuscular blockade during total hip arthroplasty to improve postoperative quality of recovery and immune function: protocol for a randomised controlled study

Autor: Veerle Bijkerk, Jetze Visser, Lotte M C Jacobs, Christiaan Keijzer, Michiel C Warlé

Publikováno v: BMJ Open, Vol 13, Iss 8 (2023)

Introduction There is accumulating evidence that deep neuromuscular blockade (NMB) improves intraoperative surgical conditions during laparoscopic surgery. Studies investigating the effects of deep NMB in open surgery are scarce. In theory, by limiti

Externí odkaz: https://doaj.org/article/6de532d11d1744b2a8fad31e4bf104e5

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Akademický článek

Drug Discovery in the Field of β-Lactams: An Academic Perspective

Autor: Lian M. C. Jacobs, Patrick Consol, Yu Chen

Publikováno v: Antibiotics, Vol 13, Iss 1, p 59 (2024)

β-Lactams are the most widely prescribed class of antibiotics that inhibit penicillin-binding proteins (PBPs), particularly transpeptidases that function in peptidoglycan synthesis. A major mechanism of antibiotic resistance is the production of β-

Externí odkaz: https://doaj.org/article/e8ee6e3f89b04233bcdf42f6219f9c5f

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Akademický článek

ChAdOx1 vaccination, blood coagulation, and inflammation: No effect on coagulation but increased interleukin‐6

Autor: Loes H. Willems, Magdolna Nagy, Hugo Ten Cate, Henri M. H. Spronk, Lotte M. C. Jacobs, Josephine Kranendonk, Maaike vanLeeuwen, Danielle Meijer, Saskia Middeldorp, Laszlo A. Groh, Michiel C. Warlé

Publikováno v: Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 8, Pp n/a-n/a (2021)

Abstract Background Vaccination is the leading approach in combatting the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic. ChAdOx1 nCoV‐19 vaccination (ChAdOx1) has been linked to a higher frequency of rare thrombosis and

Externí odkaz: https://doaj.org/article/cc5c9f78cbc34b40b9e9e198790c75b7

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Vascular Function, Systemic Inflammation, and Coagulation Activation 18 Months after COVID-19 Infection: An Observational Cohort Study

Autor: Loes H. Willems, Lotte M. C. Jacobs, Laszlo A. Groh, Hugo ten Cate, Henri M. H. Spronk, Boden Wilson-Storey, Gerjon Hannink, Sander M. J. van Kuijk, Chahinda Ghossein-Doha, Magdi Nagy, Dick H. J. Thijssen, André S. van Petersen, Michiel C. Warlé

Publikováno v: Journal of Clinical Medicine, 12, 4
Journal of Clinical Medicine, 12
Journal of Clinical Medicine
Volume 12
Issue 4
Pages: 1413
Journal of Clinical Medicine, 12(4):1413. Multidisciplinary Digital Publishing Institute (MDPI)

Introduction: Among its effect on virtually all other organs, COVID-19 affects the cardiovascular system, potentially jeopardizing the cardiovascular health of millions. Previous research has shown no indication of macrovascular dysfunction as reflec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd87f06e1f280851d3f853a97c0df0e

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Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir

Autor: Yanmei Hu, Eric M. Lewandowski, Haozhou Tan, Xiaoming Zhang, Ryan T. Morgan, Xiujun Zhang, Lian M. C. Jacobs, Shane G. Butler, Maura V. Gongora, John Choy, Xufang Deng, Yu Chen, Jun Wang

Publikováno v: bioRxiv : the preprint server for biology.

The SARS-CoV-2 main protease (Mpro) is the drug target of Pfizer’s oral drug Paxlovid. The emergence of SARS-CoV-2 variants with mutations in Mpro raised the alarm of potential drug resistance. In this study, we identified 100 naturally occurring M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8be467d61742063e805ad24ebad2726
https://pubmed.ncbi.nlm.nih.gov/36119652

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Metallocenyl 7-ACA Conjugates: Antibacterial Activity Studies and Atomic-Resolution X-ray Crystal Structure with CTX-M β-Lactamase

Autor: Aleksandra Kowalczyk, Konrad Kowalski, Łukasz Szczupak, Manuel Arruebo, Gracia Mendoza, Lian M. C. Jacobs, Paweł Stączek, Eric M. Lewandowski, Yu Chen

Publikováno v: Chembiochem : a European journal of chemical biology. 21(15)

The conjugation of organometallic groups to current β-lactam antibiotics is a field of increasing study due to the ability of certain organometallic groups to enhance the antibiotic potency of these drugs. Herein, we report the antibacterial propert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9c47c20ee80aa3acc643d72c3261e2
https://pubmed.ncbi.nlm.nih.gov/32182393

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Allergic contact dermatitis caused by resveratrol in a cosmetic cream

Autor: M C Jacobs, Anne Herman, Alexia Degraeuwe

Publikováno v: Contact Dermatitis, Vol. 82, no.6, p. 412-413 (2020)

Allergic contact dermatitis due to cosmetic products is frequent. Fragrances and preservatives are the most common allergens, but every component can be responsible for contact dermatitis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8dec2c96a52d7379da76cd17f1a809
https://hdl.handle.net/2078.1/230023

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