Novel approach to repeated arterial blood sampling in small animal PET

Autor: David Vállez García, M. C. Houwertjes, Philip H. Elsinga, Xiaoyun Zhou, Jurgen W. A. Sijbesma, Chantal Kwizera, Rudi Dierckx, Riemer H. J. A. Slart, Janine Doorduin, Bram Maas, Peter Meerlo, Aren van Waarde

Publikováno v: Molecular Imaging and Biology
Sijbesma, J W A, Zhou, X, Vállez García, D, Houwertjes, M C, Doorduin, J, Kwizera, C, Maas, B, Meerlo, P, Dierckx, R A, Slart, R H J A, Elsinga, P H & van Waarde, A 2016, ' Novel Approach to Repeated Arterial Blood Sampling in Small Animal PET : Application in a Test-Retest Study with the Adenosine A1 Receptor Ligand [ 11 C]MPDX ', Molecular Imaging and Biology, vol. 18, no. 5, pp. 715-723 . https://doi.org/10.1007/s11307-016-0954-9
Molecular Imaging and Biology, 18(5), 715-723. SPRINGER
Molecular Imaging and Biology, 18(5), 715-723. Springer New York

Purpose: Small animal positron emission tomography (PET) can be used to detect small changes in neuroreceptor availability. This often requires rapid arterial blood sampling. However, current catheterization procedures do not allow repeated blood sam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09c4933db631f70d7b50423b4cfa620
https://hdl.handle.net/11370/403c8c28-c311-44a8-b5bb-09752f98f1fd

Early organ-specific endothelial activation during hemorrhagic shock and resuscitation

Autor: Ann De Haes, Grietje Molema, Francis M. Wulfert, M. C. Houwertjes, Matijs van Meurs, Leon Aarts, Ageeth J. Knol

Publikováno v: Shock, 29(2), 291-299. LIPPINCOTT WILLIAMS & WILKINS

Multiple organ dysfunction syndrome (MODS) is a complication of hemorrhagic shock (HS) and related to high morbidity and mortality. Interaction of activated neutrophils and endothelial cells is considered to play a prominent role in the pathophysiolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf15750e775a1b0c8a22f400856b6c7
https://hdl.handle.net/11370/e7cde09e-fcdc-47ce-9585-4e7cffe76952

Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming: The role of renal H2S-producing enzymes

Autor: Maaike Goris, Fatemeh Talaei, Anne H. Epema, Hjalmar R. Bouma, George J. Dugbartey, M. C. Houwertjes, Robert H. Henning

Publikováno v: European Journal of Pharmacology, 769, 225-233. ELSEVIER SCIENCE BV

Hypothermia and rewarming produces organ injury through the production of reactive oxygen species. We previously found that dopamine prevents hypothermia and rewarming-induced apoptosis in cultured cells through increased expression of the H2S-produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa51da3df6869fcea71dd559995ad5dc
https://research.rug.nl/en/publications/4ba5402b-21f6-4e9b-9dda-55542a66cc4c

Pharmacokinetic–Pharmacodynamic Modeling of Rocuronium in Case of a Decreased Number of Acetylcholine Receptors

Autor: Johannes H. Proost, Mark H. De Baets, M. C. Houwertjes, Ann De Haes, J. Mark K. H. Wierda, Maurice H. W. Stassen

Publikováno v: Anesthesiology. 98:133-142

Background In myasthenic patients, the sensitivity for nondepolarizing relaxants is increased and the time course of effect is prolonged due to a reduced number of functional acetylcholine receptors at the neuromuscular junction. The authors investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e6b052701a9f3b155107cb3852838ed
https://doi.org/10.1097/00000542-200301000-00022

Platelet dynamics during natural and pharmacologically induced torpor and forced hypothermia

Autor: Maaike Goris, M. C. Houwertjes, A.M. Strijkstra, Annika Herwig, Robert H. Henning, George J. Dugbartey, Ate S. Boerema, P. Vogelaar, Hjalmar R. Bouma, Edwin L de Vrij

Publikováno v: PLoS ONE, 9(4):e93218. PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 9, Iss 4, p e93218 (2014)
PLoS ONE

Hibernation is an energy-conserving behavior in winter characterized by two phases: torpor and arousal. During torpor, markedly reduced metabolic activity results in inactivity and decreased body temperature. Arousal periods intersperse the torpor bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23659285ebd9abcf62c1bdba87c328e2
https://research.rug.nl/en/publications/c7d027b0-8b74-465d-b940-0e55b7640179