Zobrazeno 1 - 10
of 21
pro vyhledávání: '"M C, Hollander"'
Autor:
Carl W. Anderson, Dmitry V. Bulavin, Ettore Appella, Shin'ichi Saito, Kazuyasu Sakaguchi, Albert J. Fornace, M C Hollander
Publikováno v:
The EMBO Journal. 18:6845-6854
Components of the ras signaling pathway contribute to activation of cellular p53. In MCF-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbe2cbdb2eccc87173ceff178ffbe92
https://doi.org/10.1093/emboj/18.23.6845
https://doi.org/10.1093/emboj/18.23.6845
Autor:
Chu-Xia Deng, Sheikh Ms, K. Lundgren, Qimin Zhan, Pedro M. Fernández-Salguero, E. Tolosa, W. F. Morgan, Jonathan D. Ashwell, T. A. Molinaro, L. Augeri-Henmueller, Dmitry V. Bulavin, Albert J. Fornace, R. Shehee, M. P. Rosenberg, K. E. Kim, M C Hollander
Publikováno v:
Nature Genetics. 23:176-184
Gadd45a-null mice generated by gene targeting exhibited several of the phenotypes characteristic of p53-deficient mice, including genomic instability, increased radiation carcinogenesis and a low frequency of exencephaly. Genomic instability was exem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d90a04670f92e39f0cbc12af59aae17
https://doi.org/10.1038/13802
https://doi.org/10.1038/13802
Autor:
Kontny U, Maite Iglesias, Craig D. Woodworth, Yu K, Albert J. Fornace, Qimin Zhan, M C Hollander, I Alamo
Publikováno v:
Oncogene. 18:297-304
In the cellular response to genotoxic stress, cell cycle checkpoint and apoptosis are considered to be two of the major biological events in maintaining genomic stability. The tumor suppressor p53 has been shown to play critical roles in these stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97658839024203377547d4824d0be22a
https://doi.org/10.1038/sj.onc.1202310
https://doi.org/10.1038/sj.onc.1202310
Autor:
J R Mercado-Matos, Jaclyn LoPiccolo, Shigeru Kawabata, Willie Wilson, Phillip A. Dennis, Joell J. Gills, M C Hollander
Publikováno v:
Cell Death & Disease
Exploiting protein homeostasis is a new therapeutic approach in cancer. Nelfinavir (NFV) is an HIV protease inhibitor that induces endoplasmic reticulum (ER) stress in cancer cells. Under conditions of ER stress, misfolded proteins are transported fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0fcd7fe9238f38c90adfb4f259b9bf
https://pubmed.ncbi.nlm.nih.gov/22825471
https://pubmed.ncbi.nlm.nih.gov/22825471
Autor:
Qimin Zhan, K A Lord, M C Hollander, Dan A. Liebermann, Barbara Hoffman, Albert J. Fornace, I Alamo, F. Carrier, David Ron, Kurt W. Kohn
Publikováno v:
Molecular and Cellular Biology. 14:2361-2371
A remarkable overlap was observed between the gadd genes, a group of often coordinately expressed genes that are induced by genotoxic stress and certain other growth arrest signals, and the MyD genes, a set of myeloid differentiation primary response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420b34eec2d53f19c4be7b9ff20667be
https://doi.org/10.1128/mcb.14.4.2361
https://doi.org/10.1128/mcb.14.4.2361
Publikováno v:
Proceedings of the National Academy of Sciences. 91:1554-1558
A technique to detect RNA-binding proteins (RBP) involving hybridization of RNA probe to proteins transferred to a membrane was used to study RBP in different mammalian cells and in cells after genotoxic stress. With this approach, up to 13 proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033e33004cc191fe408f80738c909069
https://doi.org/10.1073/pnas.91.4.1554
https://doi.org/10.1073/pnas.91.4.1554
K-ras mutations are associated with smoking-induced lung cancer and poor clinical outcomes. In mice, K-ras mutations are sufficient to induce lung tumors, which require phosphoinoside-3-kinase (PI3K) and further downstream, mammalian target of rapamy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bd3e14873683378fa963ad8d67af2e
https://europepmc.org/articles/PMC4133779/
https://europepmc.org/articles/PMC4133779/
Publikováno v:
Journal of Biological Chemistry. 268:24385-24393
The gadd45 gene is transcriptionally activated through at least two different mechanisms; one following treatment with base-damaging agents such as methylmethane sulfonate and UV radiation and the other following ionizing radiation. To investigate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa669a8df4c86f449e92ce06f2443f8e
https://doi.org/10.1016/s0021-9258(20)80537-7
https://doi.org/10.1016/s0021-9258(20)80537-7
Autor:
M. Pingul, L. Shah, S. Denton, E. Walenz, M. Weisgerber, S. Conley, S.-T. T. Li, M. C. Hollander
Publikováno v:
Pediatrics in review. 28(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb1854de2934d85e429df0b9c00a3cd
https://pubmed.ncbi.nlm.nih.gov/17601939
https://pubmed.ncbi.nlm.nih.gov/17601939
Publikováno v:
Cell cycle (Georgetown, Tex.). 4(5)
Gadd45a is a p53-regulated gene whose protein product, like p53, is involved in maintenance of genome stability. Specifically, deletion of Gadd45a leads to extensive aneuploidy as a consequence of centrosome amplification and subsequent abnormal segr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fe216943316e38988eb68649a78a77
https://pubmed.ncbi.nlm.nih.gov/15846075
https://pubmed.ncbi.nlm.nih.gov/15846075