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Gene therapy of cystic fibrosis (CF) airways: a review emphasizing targeting with lactose

Autor: D T, Klink, M C, Glick, T F, Scanlin

Publikováno v: Glycoconjugate journal. 18(9)

Cystic fibrosis is a disease for which a number of Phase I clinical trials of gene therapy have been initiated. Several factors account for the high level of interest in a gene therapy approach to this disease. CF is the most common lethal inherited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a3a828fbdc00de68d1f589622f47079
https://pubmed.ncbi.nlm.nih.gov/12386459

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Terminal glycosylation in cystic fibrosis (CF): a review emphasizing the airway epithelial cell

Autor: A D, Rhim, L, Stoykova, M C, Glick, T F, Scanlin

Publikováno v: Glycoconjugate journal. 18(9)

Altered terminal glycosylation, with increased fucosylation and decreased sialylation is a hallmark of the cystic fibrosis (CF) glycosylation phenotype. Oligosaccharides purified from the surface membrane glycoconjugates of CF airway epithelial cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39a6f25cd5472d638a7135319014f850
https://pubmed.ncbi.nlm.nih.gov/12386452

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Terminal glycosylation and disease: influence on cancer and cystic fibrosis

Autor: T F, Scanlin, M C, Glick

Publikováno v: Glycoconjugate journal. 17(7-9)

Terminal glycosylation has been a recurring theme of the laboratory. In cystic fibrosis (CF), decreased sialic acid and increased fucosyl residues in alpha1,3 position to antennary N-acetyl glucosamine is the CF glycosylation phenotype. The glycosyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02b6ebdba2ec6ea3b30adedb828c8968
https://pubmed.ncbi.nlm.nih.gov/11421353

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Terminal glycosylation of cystic fibrosis airway epithelial cells

Autor: A D, Rhim, V A, Kothari, P J, Park, A E, Mulberg, M C, Glick, T F, Scanlin

Publikováno v: Glycoconjugate journal. 17(6)

Cystic fibrosis (CF) has a characteristic glycosylation phenotype usually expressed as a decreased ratio of sialic acid to fucose. The glycosylation phenotype was found in CF/T1 airway epithelial cells (deltaF508/deltaF508). When these cells were tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2852c63cbe786df730c4aa6b13e1ef74
https://pubmed.ncbi.nlm.nih.gov/11294504

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Purification and characterization of GDP-L-Fuc: N-acetyl beta-D-glucosaminide alpha1--6fucosyltransferase from human blood platelets

Autor: J, Kamińska, M C, Glick, J, Kościelak

Publikováno v: Glycoconjugate journal. 15(8)

c-6-L-Fucosyltransferase (alpha1,6FucT; EC 2.4.1.68) from human platelets, the enzyme that is released into serum during coagulation of blood, was purified 100,000-fold. The purification required three sequential chromatographic steps: chromatofocusi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a5e69717a68fdd2deac12765d1895f2
https://pubmed.ncbi.nlm.nih.gov/9870354

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Turnover of the cystic fibrosis transmembrane conductance regulator (CFTR): slow degradation of wild-type and delta F508 CFTR in surface membrane preparations of immortalized airway epithelial cells

Autor: X, Wei, R, Eisman, J, Xu, A D, Harsch, A E, Mulberg, C L, Bevins, M C, Glick, T F, Scanlin

Publikováno v: Journal of cellular physiology. 168(2)

The protein product of the cystic fibrosis (CF) gene, termed the cystic fibrosis transmembrane conductance regulator (CFTR), is known to function as an apical chloride channel at the surface of airway epithelial cells. It has been proposed that CFTR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8a803830919a91806e88bb2f5e54608
https://pubmed.ncbi.nlm.nih.gov/8707873

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Purification and characterization of GDP-L-fucose-N-acetyl beta-D-glucosaminide alpha 1----6fucosyltransferase from cultured human skin fibroblasts. Requirement of a specific biantennary oligosaccharide as substrate

Autor: J A, Voynow, R S, Kaiser, T F, Scanlin, M C, Glick

Publikováno v: The Journal of biological chemistry. 266(32)

GDP-L-fucose-N-acetyl-beta-D-glucosaminide alpha 1----6fucosyltransferase which catalyzes the transfer of fucose from GDP-L-fucose to the asparagine-linked N-acetyl-beta-D-glucosamine of N-linked glycoproteins has been purified 37,000-fold from cultu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20d7b8b63ae3b9be66c69007a6969371
https://pubmed.ncbi.nlm.nih.gov/1939186

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Purification and characterization of GDP-L-Fuc-N-acetyl-beta-D-glucosaminide alpha 1----3fucosyltransferase from human neuroblastoma cells. Unusual substrate specificities of the tumor enzyme

Autor: C S, Foster, D R, Gillies, M C, Glick

Publikováno v: The Journal of biological chemistry. 266(6)

Fucosyl residues in the alpha 1----3 linkage to N-acetylglucosamine (Fuc alpha 1----3GlcNAc) on oligosaccharides of glycoproteins and glycolipids have been detected in certain human tumors and are developmentally expressed (reviewed in Foster, C. S.,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a57c0ebf00ce044fdc041bd10b4ef7ea
https://pubmed.ncbi.nlm.nih.gov/1995616

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