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Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells

Autor: H J Zweerink, M C Gammon, U Utz, S Y Sauma, T Harrer, J C Hawkins, R P Johnson, A Sirotina, J D Hermes, B D Walker

Publikováno v: The Journal of Immunology. 150:1763-1771

The ability of minigene-encoded viral peptide epitopes to be presented by class I molecules in the absence of MHC-encoded transporters has been evaluated in mutant T2 cells. These cells have a large deletion in the class II MHC region that includes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bed18ce94df84489104bf7a55204573
https://doi.org/10.4049/jimmunol.150.5.1763

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Endogenous loading of HLA-A2 molecules with an analog of the influenza virus matrix protein-derived peptide and its inhibition by an exogenous peptide antagonist

Autor: M C Gammon, M A Bednarek, W E Biddison, S S Bondy, J D Hermes, G E Mark, A R Williamson, H J Zweerink

Publikováno v: The Journal of Immunology. 148:7-12

Episomal plasmids (p8901) with minigenes coding for the influenza virus matrix peptide amino acids 57-68 (KGILGFVFTLTV; referred to as M57-68) or coding for a modified peptide were introduced into HLA-A2-positive target cells. The association of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae6e652db52c91188f46ba35febce5b6
https://doi.org/10.4049/jimmunol.148.1.7

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The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2

Autor: M A Bednarek, S Y Sauma, M C Gammon, G Porter, S Tamhankar, A R Williamson, H J Zweerink

Publikováno v: The Journal of Immunology. 147:4047-4053

Influenza virus matrix protein-derived peptides were synthesized based on the amino acid motifs for HLA-A2 bound self peptides. Among these peptides a nonamer (amino acids 58 through 66: G I L G F V F T L) was found to be 100 to 1000 times more effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adf1dcf06945a739ca2d71fd7d17141c
https://doi.org/10.4049/jimmunol.147.12.4047

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