Zobrazeno 1 - 10
of 13
pro vyhledávání: '"M C, Custer"'
Publikováno v:
The Journal of Immunology. 148:2622-2629
The systemic administration of human rIL-6 to mice resulted in the regression of established, 3-day pulmonary micrometastases from two weakly immunogenic tumors, but not from a nonimmunogenic tumor, in the absence of observable toxicity. Although IL-
Publikováno v:
The Journal of Immunology. 146:150-155
Induction of lymphokine-activated killer (LAK) activity by IL-2 has been described and characterized as broadly cytolytic activity against both fresh and cultured tumors. rIL-7 in the absence of IL-2 also induces LAK activity in human cells. This act
Autor:
M I, Nishimura, D, Avichezer, M C, Custer, C S, Lee, C, Chen, M R, Parkhurst, R A, Diamond, P F, Robbins, D J, Schwartzentruber, S A, Rosenberg
Publikováno v:
Cancer research. 59(24)
It is generally considered that MHC class I-restricted antigens are recognized by CD8+ T cells, whereas MHC class II-restricted antigens are recognized by CD4+ T cells. In the present study, we report an MHC class I-restricted CD4+ T cell isolated fr
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(1)
The tumor-associated-Ag MART-1 is expressed by most human melanomas. The genes encoding an alphabeta TCR from a MART-1-specific, HLA-A2-restricted, human T cell clone have been efficiently transferred and expressed in human PBL. These retrovirally tr
Autor:
T M, Clay, M C, Custer, M D, McKee, M, Parkhurst, P F, Robbins, K, Kerstann, J, Wunderlich, S A, Rosenberg, M I, Nishimura
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(3)
In a recent clinical trial, HLA-A2+ melanoma patients were vaccinated with a peptide derived from the melanoma Ag gp100, which had been modified at the second position (g9-209 2M) to enhance MHC binding affinity. Vaccination led to a significant incr
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 148(8)
The systemic administration of human rIL-6 to mice resulted in the regression of established, 3-day pulmonary micrometastases from two weakly immunogenic tumors, but not from a nonimmunogenic tumor, in the absence of observable toxicity. Although IL-
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 146(1)
Induction of lymphokine-activated killer (LAK) activity by IL-2 has been described and characterized as broadly cytolytic activity against both fresh and cultured tumors. rIL-7 in the absence of IL-2 also induces LAK activity in human cells. This act
Publikováno v:
Journal of biological response modifiers. 9(2)
Interferon-gamma (IFN) and tumor necrosis factor-alpha (TNF) were examined for their ability to enhance major histocompatibility complex (MHC) expression on a variety of human tumor and normal tissue targets. Enhanced expression of MHC correlated wit
Publikováno v:
The Journal of Immunology. 142:3452-3461
IL-4 is a pluripotent lymphokine acting on various cell types. We investigated the role of human IL-4 on the generation of lymphokine-activated killer (LAK) activity. Human IL-4 alone did not induce LAK activity and inhibited IL-2 induction of LAK ac
Autor:
J N Hansen, M C Custer
Publikováno v:
Applied and Environmental Microbiology. 45:942-949
Tryptone is a pancreatic digest of casein which contains a heterogeneous mixture of substances that react with nitrite when heated in the presence of sodium thioglycolate to form a bacteriostatic agent which inhibits outgrowth of Bacillus cereus T sp