Zobrazeno 1 - 9
of 9
pro vyhledávání: '"M C, Cirtain"'
Publikováno v:
Proceedings of the National Academy of Sciences. 86:5128-5132
We have shown previously that reserpine is an effective "modulator" of P-glycoprotein-associated multidrug resistance (MDR). In addition to enhancing drug cytotoxicity in our multidrug-resistant human leukemia cell line, CEM/VLB100, reserpine strongl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e323710d935d5a9d8be317c805fa4d36
https://doi.org/10.1073/pnas.86.13.5128
https://doi.org/10.1073/pnas.86.13.5128
Publikováno v:
Biochemical and Biophysical Research Communications. 153:959-966
Multidrug resistant cells are characterized by decreased drug accumulation and retention, thought to be mediated by a high molecular weight glycoprotein, P-glycoprotein (P-gp). Agents such as verapamil have been shown to increase anticancer drug cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe7b9854b723e18acbed9814a1cbcbe
https://doi.org/10.1016/s0006-291x(88)81321-4
https://doi.org/10.1016/s0006-291x(88)81321-4
Autor:
W T, Beck, M C, Cirtain, M K, Danks, R L, Felsted, A R, Safa, J S, Wolverton, D P, Suttle, J M, Trent
Publikováno v:
Cancer research. 47(20)
We previously described the cross-resistance patterns and cellular pharmacology of a human leukemic cell line, CEM/VM-1, selected for resistance to the epipodophyllotoxin teniposide (M. K. Danks et al., Cancer Res., 47: 1297-1301, 1987). Compared to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b03f4141975fc8454dc75aa7296d55e6
https://pubmed.ncbi.nlm.nih.gov/2888532
https://pubmed.ncbi.nlm.nih.gov/2888532
Publikováno v:
Biochemistry. 27(24)
The simultaneous development of resistance to the cytotoxic effects of several classes of natural product anticancer drugs, after exposure to only one of these agents, is referred to as multiple drug resistance (MDR). At least two distinct mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdf45626bce7984afd91f4eeb943303
https://pubmed.ncbi.nlm.nih.gov/2853972
https://pubmed.ncbi.nlm.nih.gov/2853972
Publikováno v:
Progress in clinical and biological research. 223
The studies presented in this report demonstrate that Vinca alkaloid-resistant human leukemic lymphoblasts display patterns of cross-resistance to other drugs that differ from those of cell lines selected for primary resistance to anthracyclines or e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c51f7df6c30298173710b2d53cacfb9
https://pubmed.ncbi.nlm.nih.gov/3468517
https://pubmed.ncbi.nlm.nih.gov/3468517
Publikováno v:
Molecular pharmacology. 24(3)
We studied the accumulation of [3H]vinblastine (VLB) by lines of CCRF-CEM cultured human leukemic lymphoblasts that were either sensitive or resistant to the drug. Neither cell line metabolized VLB, nor selectively retained any radioactive impurities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::658daa4558a965af23df418215b83804
https://pubmed.ncbi.nlm.nih.gov/6579344
https://pubmed.ncbi.nlm.nih.gov/6579344
Publikováno v:
Cancer research. 46(2)
We examined the ability of verapamil, a Ca2+ channel blocker, to overcome Vinca alkaloid and multiple drug resistance in our CEM/VLB100 and CEM/DOX human leukemic lymphoblasts. Compared with the parent CCRF-CEM cells, CEM/VLB100 cells are approximate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::339bbe4ca8bf16fe1e825dbc35667ea0
https://pubmed.ncbi.nlm.nih.gov/3455678
https://pubmed.ncbi.nlm.nih.gov/3455678
Publikováno v:
Cancer research. 46(9)
A common feature of mammalian cell lines selected for multiple drug resistance is the overexpression of a high-molecular-weight surface membrane glycoprotein(s). While its amount has been shown to be related to the degree of resistance of such cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4f88bbe098f75241af1d981d8ed4612
https://pubmed.ncbi.nlm.nih.gov/3015390
https://pubmed.ncbi.nlm.nih.gov/3015390
Publikováno v:
Journal of Ethnopharmacology. 18:297
We examined the ability of verapamil, a Ca2+ channel blocker, to overcome Vinca alkaloid and multiple drug resistance in our CEM/VLB100 and CEM/DOX human leukemic lymphoblasts. Compared with the parent CCRF-CEM cells, CEM/VLB100 cells are approximate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50eb57a930dbd969c609928dd1c3ec9f
https://doi.org/10.1016/0378-8741(86)90008-5
https://doi.org/10.1016/0378-8741(86)90008-5