Zobrazeno 1 - 10
of 1 029
pro vyhledávání: '"M Bradbury"'
Autor:
Fortunato Ferrara, Adeline Fanni, Andre A. R. Teixeira, Esteban Molina, Camila Leal-Lopes, Ashley DeAguero, Sara D’Angelo, M. Frank Erasmus, Laura Spector, Luis Antonio Rodriguez Carnero, Jianquan Li, Thomas J. Pohl, Nikolai Suslov, Klervi Desrumeaux, Conor McMahon, Sagar Kathuria, Andrew R. M. Bradbury
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
We previously described an in vitro single-chain fragment (scFv) library platform originally designed to generate antibodies with excellent developability properties. The platform design was based on the use of clinical antibodies as scaffolds into w
Externí odkaz:
https://doaj.org/article/08adf8bbba7940a8b4cc3c5378c32316
Autor:
John J. Krais, David J. Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson, Pooja Patel, Zemin Liu, Ryan Neumann-Domer, Robert G. Betsch, Andrea J. Bernhardy, Alice M. Bradbury, Jason Conger, Wei-Ting Yueh, Joseph Nacson, Richard T. Pomerantz, Gaorav P. Gupta, Joseph R. Testa, Neil Johnson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Homologous recombination (HR)-deficiency induces a dependency on DNA polymerase theta (Polθ/Polq)-mediated end joining, and Polθ inhibitors (Polθi) are in development for cancer therapy. BRCA1 and BRCA2 deficient cells are thought to be s
Externí odkaz:
https://doaj.org/article/1134d3c423c24ee9b10823404374aee9
Autor:
M. Frank Erasmus, Fortunato Ferrara, Sara D’Angelo, Laura Spector, Camila Leal-Lopes, André A. Teixeira, Jesper Sørensen, Suhani Nagpal, Kathryn Perea-Schmittle, Alok Choudhary, William Honnen, David Calianese, Luis Antonio Rodriguez Carnero, Simon Cocklin, Victor Greiff, Abraham Pinter, Andrew R. M. Bradbury
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Therapeutic antibody discovery often relies on in-vitro display methods to identify lead candidates. Assessing selected output diversity traditionally involves random colony picking and Sanger sequencing, which has limitations. Next-generati
Externí odkaz:
https://doaj.org/article/9f677d7c2e9c4172a391dac8c4424094
Autor:
M. Frank Erasmus, Fortunato Ferrara, Sara D’Angelo, Laura Spector, Camila Leal-Lopes, André A. Teixeira, Jesper Sørensen, Suhani Nagpal, Kathryn Perea-Schmittle, Alok Choudhary, William Honnen, David Calianese, Luis Antonio Rodriguez Carnero, Simon Cocklin, Victor Greiff, Abraham Pinter, Andrew R. M. Bradbury
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/341f118a08db4ff7bb9c491729af0860
Autor:
M. Frank Erasmus, Molly Dovner, Fortunato Ferrara, Sara D’Angelo, André A. Teixeira, Camila Leal-Lopes, Laura Spector, Elizabeth Hopkins, Andrew R. M. Bradbury
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAccurate and efficient affinity measurement techniques are essential for the biophysical characterization of therapeutic monoclonal antibodies, one of the fastest growing drug classes. Surface plasmon resonance (SPR) is widely used for determ
Externí odkaz:
https://doaj.org/article/8d9d6973ecb14fbf9cc087829f04f11c
Autor:
Allison M. Bradbury
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101137- (2023)
Externí odkaz:
https://doaj.org/article/4bc1de9201f14e599ba6f6bec4b69f3d
Autor:
Jessica A. Herstine, Pi-Kai Chang, Sergiy Chornyy, Tamara J. Stevenson, Jessica Rediger, Julia Wentz, Nettie Pyne, Joshua L. Bonkowsky, Allison M. Bradbury
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 119-119 (2024)
OBJECTIVES/GOALS: Vanishing White Matter Disease (VWM), is a childhood neurodegenerative leukodystrophy that presents with motor deficits, neurologic decline, and seizures leading to death.There are no treatments. Herein we investigate adeno-associat
Externí odkaz:
https://doaj.org/article/71b6dafb62cc4d2891f65f7dd3fc59ae
Autor:
Hilary M. Bradbury, Chris Riedy, Susanna Carman, Susanne Pratt, Bem Le Hunte, Meghna Guhathakurta
Publikováno v:
Journal of Awareness-Based Systems Change, Vol 3, Iss 1 (2023)
This paper is foremost about experiments in embodying a transformative narrative of a self that makes possible mutual collaborative practice with others. The focus is less on what we ought to think or do, but rather on subtracting, letting go, self-i
Externí odkaz:
https://doaj.org/article/5e037e466aa3431e8a89136c39c8b019
Autor:
M. Frank Erasmus, Fortunato Ferrara, Sara D’Angelo, Laura Spector, Camila Leal‑Lopes, André A. Teixeira, Jesper Sørensen, Suhani Nagpal, Kathryn Perea‑Schmittle, Alok Choudhary, William Honnen, David Calianese, Luis Antonio Rodriguez Carnero, Simon Cocklin, Victor Greiff, Abraham Pinter, Andrew R. M. Bradbury
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/857d7a448bd248a0ae37d45019f7079d
Autor:
Fortunato Ferrara, M. Frank Erasmus, Sara D’Angelo, Camila Leal-Lopes, André A. Teixeira, Alok Choudhary, William Honnen, David Calianese, Deli Huang, Linghan Peng, James E. Voss, David Nemazee, Dennis R. Burton, Abraham Pinter, Andrew R. M. Bradbury
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The most potent neutralizing antibodies are typically generated from convalescent patients and immunized animals. Here, the authors show it is possible to generate highly potent human neutralizing antibodies against the SARS-CoV-2 spike protein direc
Externí odkaz:
https://doaj.org/article/70d41bbd50c147b58d9359405fbd65f0