Zobrazeno 1 - 10
of 65
pro vyhledávání: '"M Bouygues"'
Autor:
F Boccara, A Fonteille, M Chauvet-Droit, C Jansen, S Ederhy, V Vitrat, L Soulat-Dufour, V Tolsma, E Piet, S Adavane-Scheuble, L Belle, M Bouygues, A Valran, P Nhan, A Cohen
Publikováno v:
European Heart Journal. 43
Background People living with HIV (PLWH) have a higher risk of CAD. Whether coronary artery calcification (CAC) score could better stratify the CV risk remains debated in this middle age population. Purpose We conducted the French CAC score study to
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1181-1189
Based on the specific PhePro proteolytic cleavage of the HIV-protease, we synthesized short pseudopeptides incorporating a 2-(phenylthio)pyrrolidin-3-one ring. We previously described various analogues based on this scaffold. We report herein a paral
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 9:78
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2023-2026
The synthesis of new phenylalanine-2-thiophenoxy-3-pyrrolidinones is described. Anti-HIV recombinant protease assays and HIV infected cell culture assays (observation of syncytia) demonstrated the potent anti-HIV activity of this new class of pseudop
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1861-1866
We report the synthesis and the anti-HIV activities of new C 2 -symmetrical and achiral N 1 ,N 3 -dibenzyl-2-hydroxy-propane isosteres. Some of them showed significant inhibitory activity with respect to HIV-infected MT4 cells (compound 6a and 7a , I
Publikováno v:
European Journal of Medicinal Chemistry. 33:445-450
Based on the specific PhePro proteolytic cleavage of the HIV protease, short pseudo-peptides incorporating a 3-pyrrolidinone ring have been synthesized. Their potencies to inhibit HIV-1 in MT4 cell culture have been evaluated and compared to that of
Autor:
Gilles Quéléver, Michel Camplo, Jean-Claude Chermann, Jean-Louis Kraus, Jean Dessolin, Patrick Vlieghe, M. Bouygues, M. Medou
Publikováno v:
Nucleosides and Nucleotides. 17:957-968
As far as linear N-Boc-polyamines conjugates elicited remarkable anti-HIV activity, the synthesis and anti-HIV properties of cyclic N-Boc-polyamines conjugates such as tetraazamacrocycle-nucleoside were studied. These new conjugates include an ester
Autor:
M. Bouygues, Michel Camplo, Patrick Vlieghe, C. Trabaud, Jean-Louis Kraus, Jean Dessolin, Jean-Claude Chermann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1353-1358
The syntheses and the anti-HIV activities of new N,N,N′,N″,N‴-pentakistetraazamacrocyles salts analogues are described. From computer modeling studies, it was found that zinc coordination capacity of these pentakis derivatives was larger than t
Autor:
Jean-Louis Kraus, Gilles Quéléver, M. Medou, Michel Camplo, M. Bouygues, Jean-Claude Chermann
Publikováno v:
ChemInform. 29
The syntheses consisting of replacement of proline amino acid by a 3-pyrrolidinone ring in Phe-Pro analogues are described. Preliminary anti-HIV studies demonstrated the potential activity of this new class of compounds.
Autor:
Jean-Claude Chermann, Jean-Louis Kraus, Jean Dessolin, M. Medou, M. Bouygues, Michel Camplo, Patrick Vlieghe, Gilles Quéléver
Publikováno v:
ChemInform. 29
As far as linear N-Boc-polyamines conjugates elicited remarkable anti-HIV activity, the synthesis and anti-HIV properties of cyclic N-Boc-polyamines conjugates such as tetraazamacrocycle-nucleoside were studied. These new conjugates include an ester