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Effects of leptin on the differentiation and metabolism of human adipocytes

Autor: H Gottschling-Zeller, Thomas Skurk, D Scriba, I. Aprath-Husmann, K. Röhrig, M Birgel, Hans Hauner

Publikováno v: International Journal of Obesity. 25:1465-1470

Leptin is an adipose protein regulating food intake in the hypothalamus. Animal studies have suggested that leptin also acts in an auto-/paracrine fashion on adipose cell function.The aim of this study was to investigate the effects of leptin on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f875cb61140be1a9a1ff998880c0754
https://doi.org/10.1038/sj.ijo.0801737

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Role of Cytokines in the Regulation of Plasminogen Activator Inhibitor-1 Expression and Secretion in Newly Differentiated Subcutaneous Human Adipocytes

Autor: M Birgel, K. Röhrig, Hans Hauner, H Gottschling-Zeller

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 20:1682-1687

Abstract —Elevated levels of plasminogen activator inhibitor-1 (PAI-1) are characteristic for obesity and are associated with increased risk of thromboembolic complications. PAI-1 recently was reported to be expressed and secreted by human adipocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50f0c0d8dab7645596ebe969e051225
https://doi.org/10.1161/01.atv.20.6.1682

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Expression pattern of tumour necrosis factor receptors in subcutaneous and omental human adipose tissue: role of obesity and non-insulin-dependent diabetes mellitus

Autor: Hans Hauner, Y M Lee, M Birgel, F Hube

Publikováno v: European Journal of Clinical Investigation. 29:672-678

Background Tumour necrosis factor α (TNF) mRNA expression has been reported to be up-regulated in adipose tissue from several rodent models of obesity and diabetes and from obese humans. This elevated expression has been assumed to be associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f4b52caf6f42330c15e1a8a59235940
https://doi.org/10.1046/j.1365-2362.1999.00520.x

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Depot-specific release of leptin from subcutaneous and omental adipocytes in suspension culture: effect of tumor necrosis factor-alpha and transforming growth factor-beta1

Autor: M Birgel, Werner F. Blum, Hans Hauner, D Scriba, H Gottschling-Zeller

Publikováno v: European journal of endocrinology. 141(4)

OBJECTIVE: Leptin, the product of the ob gene, is overexpressed in human obesity and increased serum leptin levels are closely correlated with adipose tissue mass, but the regulation of leptin production is not completely understood. The aim of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8028346e279d53c8b7a6e57724ad6c1
https://pubmed.ncbi.nlm.nih.gov/10526261

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Expression pattern of tumour necrosis factor receptors in subcutaneous and omental human adipose tissue: role of obesity and non-insulin-dependent diabetes mellitus

Autor: F, Hube, M, Birgel, Y M, Lee, H, Hauner

Publikováno v: European journal of clinical investigation. 29(8)

Tumour necrosis factor alpha (TNF) mRNA expression has been reported to be up-regulated in adipose tissue from several rodent models of obesity and diabetes and from obese humans. This elevated expression has been assumed to be associated with the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09cb7f2722d8548f3f1dee9a128eaa73
https://pubmed.ncbi.nlm.nih.gov/10457150

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