Zobrazeno 1 - 10
of 504
pro vyhledávání: '"M Behan"'
Autor:
Michael V. Schrodt, Riley M. Behan-Bush, Jesse N. Liszewski, Madeleine E. Humpal-Pash, Lauren K. Boland, Sabrina M. Scroggins, Donna A. Santillan, James A. Ankrum
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Background Immunomodulation by mesenchymal stromal cells (MSCs) can occur through trophic factor mechanisms, however, intravenously infused MSCs are rapidly cleared from the body yet a potent immunotherapeutic response is still observed. Rec
Externí odkaz:
https://doaj.org/article/f9fa036c76064ab2aa5c9e5b5e60b960
Autor:
Emanuel Gonçalves, Mark Thomas, Fiona M. Behan, Gabriele Picco, Clare Pacini, Felicity Allen, Alessandro Vinceti, Mamta Sharma, David A. Jackson, Stacey Price, Charlotte M. Beaver, Oliver Dovey, David Parry-Smith, Francesco Iorio, Leopold Parts, Kosuke Yusa, Mathew J. Garnett
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many applications. We design an optimised minimal genome-wide human CRISPR-Cas9 library (MinLibC
Externí odkaz:
https://doaj.org/article/2fa4d024f7b14d10b1fef8e9f3b2d270
Autor:
Emanuel Gonçalves, Aldo Segura‐Cabrera, Clare Pacini, Gabriele Picco, Fiona M Behan, Patricia Jaaks, Elizabeth A Coker, Donny van der Meer, Andrew Barthorpe, Howard Lightfoot, Tatiana Mironenko, Alexandra Beck, Laura Richardson, Wanjuan Yang, Ermira Lleshi, James Hall, Charlotte Tolley, Caitlin Hall, Iman Mali, Frances Thomas, James Morris, Andrew R Leach, James T Lynch, Ben Sidders, Claire Crafter, Francesco Iorio, Stephen Fawell, Mathew J Garnett
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 7, Pp 1-14 (2020)
Abstract Low success rates during drug development are due, in part, to the difficulty of defining drug mechanism‐of‐action and molecular markers of therapeutic activity. Here, we integrated 199,219 drug sensitivity measurements for 397 unique an
Externí odkaz:
https://doaj.org/article/8d3c7a8706894b218dbc302dbd8ec445
Autor:
Joshua M. Dempster, Clare Pacini, Sasha Pantel, Fiona M. Behan, Thomas Green, John Krill-Burger, Charlotte M. Beaver, Scott T. Younger, Victor Zhivich, Hanna Najgebauer, Felicity Allen, Emanuel Gonçalves, Rebecca Shepherd, John G. Doench, Kosuke Yusa, Francisca Vazquez, Leopold Parts, Jesse S. Boehm, Todd R. Golub, William C. Hahn, David E. Root, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Integrating independent large-scale pharmacogenomic screens can enable unprecedented characterization of genetic vulnerabilities in cancers. Here, the authors show that the two largest independent CRISPR-Cas9 gene-dependency screens are concordant, p
Externí odkaz:
https://doaj.org/article/7101cce4933e4a7a88c0656de01f28e5
Autor:
Gabriele Picco, Elisabeth D. Chen, Luz Garcia Alonso, Fiona M. Behan, Emanuel Gonçalves, Graham Bignell, Angela Matchan, Beiyuan Fu, Ruby Banerjee, Elizabeth Anderson, Adam Butler, Cyril H. Benes, Ultan McDermott, David Dow, Francesco Iorio, Euan Stronach, Fengtang Yang, Kosuke Yusa, Julio Saez-Rodriguez, Mathew J. Garnett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Gene fusions are observed in many cancers but their link to tumour fitness is largely unknown. Here, transcriptomic analysis combined with pharmacological and CRISPR-Cas9 screening of cancer cell lines was used to evaluate the functional linkage betw
Externí odkaz:
https://doaj.org/article/faee146ac94c4c129948d57be9f339e0
Autor:
Emanuel Gonçalves, Fiona M. Behan, Sandra Louzada, Damien Arnol, Euan A. Stronach, Fengtang Yang, Kosuke Yusa, Oliver Stegle, Francesco Iorio, Mathew J. Garnett
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background CRISPR-Cas9 genome editing is widely used to study gene function, from basic biology to biomedical research. Structural rearrangements are a ubiquitous feature of cancer cells and their impact on the functional consequences of CRI
Externí odkaz:
https://doaj.org/article/3516f76650ac43208fd3373ec80b00ab
Autor:
Frédéric Beaulieu, Wayne Knee, Victoria Nowell, Marla Schwarzfeld, Zoë Lindo, Valerie M. Behan-Pelletier, Lisa Lumley, Monica R. Young, Ian Smith, Heather C. Proctor, Sergei V. Mironov, Terry D. Galloway, David E. Walter, Evert E. Lindquist
Publikováno v:
ZooKeys, Vol 819, Iss , Pp 77-168 (2019)
Summaries of taxonomic knowledge are provided for all acarine groups in Canada, accompanied by references to relevant publications, changes in classification at the family level since 1979, and notes on biology relevant to estimating their diversity.
Externí odkaz:
https://doaj.org/article/e99faf295d674b63a16d9f66d6ecf453
Autor:
Justine M. Behan, Ramandeep Singh Arora, Franco A. Carnevale, Sameer Bakhshi, Bani Bhattacharjee, Argerie Tsimicalis
Publikováno v:
Global Qualitative Nursing Research, Vol 8 (2021)
There is a paucity of research examining children’s experiences with cancer in India. Childhood ethics is an emerging field, focusing on the moral dimension of children’s experiences, to promote children’s participation in their health care. A
Externí odkaz:
https://doaj.org/article/0a7003a066544824b48c73e1b2d3809f
Autor:
Riley M. Behan-Bush, Jesse N. Liszewski, Michael V. Schrodt, Bhavya Vats, Xueshu Li, Hans-Joachim Lehmler, Aloysius J. Klingelhutz, James A. Ankrum
Publikováno v:
Environmental Science & Technology. 57:1731-1742
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9da646fe144054beeaf3e58d00cf2168
https://doi.org/10.1021/acs.est.2c07281
https://doi.org/10.1021/acs.est.2c07281
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway
Autor:
Annie Wai Yeeng Chai, Pei San Yee, Stacey Price, Shi Mun Yee, Hui Mei Lee, Vivian KH Tiong, Emanuel Gonçalves, Fiona M Behan, Jessica Bateson, James Gilbert, Aik Choon Tan, Ultan McDermott, Mathew J Garnett, Sok Ching Cheong
Publikováno v:
eLife, Vol 9 (2020)
New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived from Asians, to identify genetic vulnerabilities that can be explored as therap
Externí odkaz:
https://doaj.org/article/3808165fca334dd0b13ce47927c27467