Zobrazeno 1 - 10
of 1 199
pro vyhledávání: '"M Beekman"'
Autor:
F. A. Bogaards, T. Gehrmann, M. Beekman, N. Lakenberg, H. E. D. Suchiman, C. P. G. M. de Groot, M. J. T. Reinders, P. E. Slagboom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Molecular effects of lifestyle interventions are typically studied in a single tissue. Here, we perform a secondary analysis on the sex-specific effects of the Growing Old TOgether trial (GOTO, trial registration number GOT NL3301 ( https://
Externí odkaz:
https://doaj.org/article/3fe10dc5ea2c483585c22b8ce02587f2
Autor:
Daniele Bizzarri, Marcel J.T. Reinders, Lieke Kuiper, Marian Beekman, Joris Deelen, Joyce B.J. van Meurs, Jenny van Dongen, René Pool, Dorret I. Boomsma, Mohsen Ghanbari, Lude Franke, Pieternella E. Slagboom, Erik B. van den Akker, J.M. Geleijnse, E. Boersma, W.E. van Spil, M.M.J. van Greevenbroek, C.D.A. Stehouwer, C.J.H. van der Kallen, I.C.W. Arts, F. Rutters, J.W.J. Beulens, M. Muilwijk, P.J.M. Elders, L.M. 't Hart, M. Ghanbari, M.A. Ikram, M.G. Netea, M. Kloppenburg, Y.F.M. Ramos, N. Bomer, I. Meulenbelt, K. Stronks, M.B. Snijder, A.H. Zwinderman, B.T. Heijmans, L.H. Lumey, C. Wijmenga, J. Fu, A. Zhernakova, J. Deelen, S.P. Mooijaart, M. Beekman, P.E. Slagboom, G.L.J. Onderwater, A.M.J.M. van den Maagdenberg, G.M. Terwindt, C. Thesing, M. Bot, B.W.J.H. Penninx, S. Trompet, J.W. Jukema, N. Sattar, I.C.C. van der Horst, P. van der Harst, C. So-Osman, J.A. van Hilten, R.G.H.H. Nelissen, I.E. Höfer, F.W. Asselbergs, P. Scheltens, C.E. Teunissen, W.M. van der Flier, J. van Dongen, R. Pool, A.H.M. Willemsen, D.I. Boomsma, H.E.D. Suchiman, J.J.H. Barkey Wolf, D. Cats, H. Mei, M. Slofstra, M. Swertz, M.J.T. Reinders, E.B. van den Akker
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105279- (2024)
Summary: Background: 1H-NMR metabolomics and DNA methylation in blood are widely known biomarkers predicting age-related physiological decline and mortality yet exert mutually independent mortality and frailty signals. Methods: Leveraging multi-omics
Externí odkaz:
https://doaj.org/article/dd2f1125885a4ef2be328f0b36ea785b
Autor:
Juliet W. Lefferts, Suzanne Kroes, Matthew B. Smith, Paul J. Niemöller, Natascha D. A. Nieuwenhuijze, Heleen N. Sonneveld van Kooten, Cornelis K. van der Ent, Jeffrey M. Beekman, Sam F. B. van Beuningen
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Epithelial ion and fluid transport studies in patient-derived organoids (PDOs) are increasingly being used for preclinical studies, drug development and precision medicine applications. Epithelial fluid transport properties in PDOs can be me
Externí odkaz:
https://doaj.org/article/57f8cce43d4e4914a932dc910bdf96e7
Autor:
M. S. Moreira, G. G. Guerreschi, W. Vlothuizen, J. F. Marques, J. van Straten, S. P. Premaratne, X. Zou, H. Ali, N. Muthusubramanian, C. Zachariadis, J. van Someren, M. Beekman, N. Haider, A. Bruno, C. G. Almudever, A. Y. Matsuura, L. DiCarlo
Publikováno v:
npj Quantum Information, Vol 9, Iss 1, Pp 1-7 (2023)
Abstract Artificial neural networks are becoming an integral part of digital solutions to complex problems. However, employing neural networks on quantum processors faces challenges related to the implementation of non-linear functions using quantum
Externí odkaz:
https://doaj.org/article/c6b733651ed3421f812c27499c272c26
Autor:
Lisa W. Rodenburg, Mieke Metzemaekers, Isabelle S. van der Windt, Shannon M. A. Smits, Loes A. den Hertog-Oosterhoff, Evelien Kruisselbrink, Jesse E. Brunsveld, Sabine Michel, Karin M. de Winter-de Groot, Cornelis K. van der Ent, Ralph Stadhouders, Jeffrey M. Beekman, Gimano D. Amatngalim
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The nasal and bronchial epithelium are unified parts of the respiratory tract that are affected in the monogenic disorder cystic fibrosis (CF). Recent studies have uncovered that nasal and bronchial tissues exhibit intrinsic variability, inc
Externí odkaz:
https://doaj.org/article/a3543cd790b84d62a839330093785ed4
Autor:
S. Helena Donner, Mariska M. Beekman, Kathrin Barth, Marcel Dicke, Bas J. Zwaan, Eveline C. Verhulst, Bart A. Pannebakker
Publikováno v:
Biological Control, Vol 188, Iss , Pp 105383- (2024)
Aphids are major agricultural pests and laboratory studies have shown that heritable bacterial endosymbionts can protect aphids against biocontrol parasitoids, but results from agricultural crop systems are lacking. Here we assess (1) which aphid spe
Externí odkaz:
https://doaj.org/article/97d3b24261f744b5a048fa4d78e7fa0e
Autor:
Bas A. Michels, Mariska M. Beekman, Jeremy Field, Jodie Gruber, Bart A. Pannebakker, Charlotte Savill, Rebecca A. Boulton
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/65f4b31d8107417882661d85cc7c06e0
Autor:
Vera Loen, Valerie Y. H. Van Weperen, Henriëtte D. M. Beekman, Joanne J. A. Van Bavel, Veronique M. F. Meijborg, Jeanne G. Van der Waal, Ruben Coronel, Marcel A. G. van der Heyden, Marc A. Vos
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: An electrical storm of Torsade de Pointes arrhythmias (TdP) can be reproducibly induced in the anesthetized chronic AV-block (CAVB) dog by infusion of the IKr-blocker dofetilide. Earlier studies showed that these arrhythmias 1) arise from
Externí odkaz:
https://doaj.org/article/f3c24e5d74424f14adc1e879c8499656
Autor:
Lisa W. Rodenburg, Isabelle S. van der Windt, Henriette H.M. Dreyer, Shannon M.A. Smits, Loes A. den Hertog - Oosterhoff, Ellen M. Aarts, Jeffrey M. Beekman, Gimano D. Amatngalim
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102337- (2023)
Summary: We present a protocol to generate organoids from air-liquid-interface (ALI)-differentiated nasal epithelia. We detail their application as cystic fibrosis (CF) disease model in the cystic fibrosis transmembrane conductance regulator (CFTR)-d
Externí odkaz:
https://doaj.org/article/d6d492fca3cb4a8cb381f693b279a9a2
Autor:
Mariska M. Beekman, Suzanne H. Donner, Jordy J. H. Litjens, Marcel Dicke, Bas J. Zwaan, Eveline C. Verhulst, Bart A. Pannebakker
Publikováno v:
Evolutionary Applications, Vol 15, Iss 10, Pp 1580-1593 (2022)
Abstract Biological control (biocontrol) of crop pests is a sustainable alternative to the use of biodiversity and organismal health‐harming chemical pesticides. Aphids can be biologically controlled with parasitoid wasps; however, variable results
Externí odkaz:
https://doaj.org/article/245e2b479bb741f381231a2b47770612