Inhibition of oncostatin M in osteoarthritic synovial fluid enhances GAG production in osteoarthritic cartilage repair

Autor: M Beekhuizen, GJVM van Osch, AGJ Bot, MCL Hoekstra, DBF Saris, WJA Dhert, LB Creemers

Publikováno v: European Cells & Materials, Vol 26, Pp 80-90 (2013)

Mediators in the synovial fluid are thought to play a major role in osteoarthritic cartilage turnover. The purpose of the current study was to investigate the role of oncostatin M (OSM) in osteoarthritis (OA) by evaluating the presence of the cytokin

Externí odkaz: https://doaj.org/article/3c8e7c96fa4041d4994fbb810388efd9

Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: Establishment and characterization of a long-term cartilage-synovium coculture

Autor: Daniel B.F. Saris, Yvonne M. Bastiaansen-Jenniskens, Wouter J.A. Dhert, M. Beekhuizen, Laura B. Creemers, Wendy Koevoet, Gerjo J.V.M. van Osch

Publikováno v: Arthritis & Rheumatism, 63(7), 1918-1927. John Wiley & Sons Ltd.

Objective Although both cartilage and synovium are affected in osteoarthritis (OA), no in vitro coculture models of human OA tissue have been described. The aim of this study was to develop an in vitro model that includes both the synovium and cartil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641f47504019c6350d2376c81d8b0366
https://doi.org/10.1002/art.30364

An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid

Autor: Lobke Gierman, G.J.V.M. van Osch, Daniel B.F. Saris, Anne-Marie Zuurmond, Laura B. Creemers, Twj Huizinga, M. Beekhuizen, W.E. van Spil

Publikováno v: Osteoarthritis and Cartilage, 7, 21, 918-922
Osteoarthritis and Cartilage, 21(7), 918-922
Osteoarthritis and Cartilage, 21(7), 918-922. W.B. Saunders
Osteoarthritis and Cartilage
Osteoarthritis and cartilage, 21(7), 918-922. W.B. Saunders Ltd

Objective: Soluble mediators in synovial fluid (SF) are acknowledged as key players in the pathophysiology of osteoarthritis (OA). However, a wide-spectrum screening of such mediators in SF is currently lacking. In this study, the levels of 47 mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6474557df2547805ccbe9a0fe5a3034
https://doi.org/10.1016/j.joca.2013.04.002

A DESCRIPTIVE STUDY OF SYNOVIAL FLUID CHANGES IN CYTOKINE, CHEMOKINE AND GROWTH FACTOR LEVELS BETWEEN OSTEOARTHRITIS PATIENTS AND HEALTHY DONORS

Autor: G.J.V.M. van Osch, T.W. Huizinga, Wouter J.A. Dhert, Anne-Marie Zuurmond, M. Beekhuizen, Laura B. Creemers, Lobke Gierman

Publikováno v: Osteoarthritis and Cartilage, 20, S79-S80
Osteoarthritis and Cartilage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71be57ddfafdf5595559d406bec82b1b
http://hdl.handle.net/1887/98740

Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model

Autor: Daniel B.F. Saris, Bernd Geurts, Laura B. Creemers, A.I. Tsuchida, J.E.J. Bekkers, Marijn Rutgers, Arjan G.J. Bot, M. Beekhuizen, Wouter J.A. Dhert, Gerjo J.V.M. van Osch

Publikováno v: Arthritis Research & Therapy, 14(6). BioMed Central Ltd.
Arthritis Research & Therapy
Arthritis research & therapy, 14(R262):R262. BioMed Central Ltd.

Introduction This study aimed to determine whether, as in osteoarthritis, increased levels of interleukin-6 (IL-6) are present in the synovial fluid of patients with symptomatic cartilage defects and whether this IL-6 affects cartilage regeneration a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d07ad863440efac1349e444b9458cc
https://doi.org/10.1186/ar4107