Zobrazeno 1 - 10
of 37
pro vyhledávání: '"M B Lees"'
Autor:
J A Encinas, M B Lees, R A Sobel, C Symonowicz, J M Greer, C L Shovlin, H L Weiner, C E Seidman, J G Seidman, V K Kuchroo
Publikováno v:
The Journal of Immunology. 157:2186-2192
Experimental autoimmune encephalomyelitis (EAE), a model for human multiple sclerosis, is a T cell-mediated autoimmune disease that can be induced in experimental animals by immunization with myelin Ags. Inbred strains of mice show varying degrees of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e21fe531a8798f5793c1e8c1c9362468
https://doi.org/10.4049/jimmunol.157.5.2186
https://doi.org/10.4049/jimmunol.157.5.2186
Publikováno v:
The Journal of Immunology. 156:371-379
To understand and develop strategies to intervene in autoimmune responses to myelin proteolipid protein (PLP), encephalitogenic epitopes must be identified. To expedite the identification of potentially immunogenic and encephalitogenic epitopes of PL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f917a1978edd02de807110baf1f5a332
https://doi.org/10.4049/jimmunol.156.1.371
https://doi.org/10.4049/jimmunol.156.1.371
Publikováno v:
The Journal of Immunology. 153:3326-3336
Previously, six T cell clones, which are specific for an encephalitogenic determinant of myelin proteolipid protein (PLP) peptide residues 139 to 151 (HSLGKWLGHPDKF), were derived from SJL mice and shown to use diverse TCR genes. To design TCR antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a7948b14e0844b3f18bdd58890a733f
https://doi.org/10.4049/jimmunol.153.7.3326
https://doi.org/10.4049/jimmunol.153.7.3326
Publikováno v:
The Journal of Immunology. 149:783-788
We previously described a synthetic peptide of myelin proteolipid protein (PLP), peptide 139-151, which induces experimental allergic encephalomyelitis in SJL/J (H-2s) mice. We have now identified an additional determinant, PLP residues 178-191, that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38ca9850118da99dc424543860c85219
https://doi.org/10.4049/jimmunol.149.3.783
https://doi.org/10.4049/jimmunol.149.3.783
Publikováno v:
The Journal of Immunology. 148:3776-3782
Proteolipid protein (PLP) is the major protein of central nervous system myelin. SJL (H-2s) mice immunized with a synthetic peptide corresponding to PLP residues 139-151 develop acute EAE. In this study, 6 IAs-restricted, CD4+, TCR alpha beta-bearing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa5bc2cb1ebd64ed52253ee58f1c135f
https://doi.org/10.4049/jimmunol.148.12.3776
https://doi.org/10.4049/jimmunol.148.12.3776
Publikováno v:
The Journal of Immunology. 146:543-549
To determine if the Ag that induces an autoimmune disease influences parental MHC haplotype molecule expression in situ in MHC heterozygotes, acute experimental allergic encephalomyelitis (EAE) was induced with different encephalitogenic peptides in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d4aac9c017614b6743e8d9c9dcc2827
https://doi.org/10.4049/jimmunol.146.2.543
https://doi.org/10.4049/jimmunol.146.2.543
Autor:
M B, Lees, J, Folch-Pi
Publikováno v:
Biographical memoirs. National Academy of Sciences (U.S.). 79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc3d295427767e6a794552bf6175459b
https://pubmed.ncbi.nlm.nih.gov/11762394
https://pubmed.ncbi.nlm.nih.gov/11762394
Autor:
O A, Bizzozero, M B, Lees
Publikováno v:
Neurochemical research. 24(2)
The hydrophobic myelin proteolipid protein (PLP) contains covalently bound long-chain fatty acids which are attached to intracellular cysteine residues via thioester linkages. To gain insight into the role of acylation in the structure and function o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bac90c5cec2aabb06e0e744b4861463
https://pubmed.ncbi.nlm.nih.gov/9972874
https://pubmed.ncbi.nlm.nih.gov/9972874
Autor:
M B, Lees
Publikováno v:
Neurochemical research. 23(3)
This review is a personal memoir of the history of proteolipids and is limited to aspects of the field with which the author has been involved in one way or another. The discovery of proteolipids was a serendipitous observation made in the course of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3d2ff9d383ded6af25458544f488351
https://pubmed.ncbi.nlm.nih.gov/9482238
https://pubmed.ncbi.nlm.nih.gov/9482238
Publikováno v:
Neurochemical research. 22(4)
Myelin proteolipid protein (PLP) contains 2 immunodominant encephalitogenic epitopes in SJL mice, namely PLP residues 139-151 and 178-191. DM20, a minor isoform of PLP, lacks residues 116-150 and consequently contains only the single major encephalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d86adc6b05d843f4c03c90a551f50e92
https://pubmed.ncbi.nlm.nih.gov/9130268
https://pubmed.ncbi.nlm.nih.gov/9130268