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First‐in‐human phase I study of infusional and bolus schedules of Deflexifol, a novel 5‐fluorouracil and leucovorin formulation, after failure of standard treatment

Autor: Richard David Ranson, Paul de Souza, Morteza Aghmesheh, Marie Ranson, Rebecca Jokela, Philip Clingan, Stephen P. Ackland, Daniel Brungs, Suzanne Parker, M B Garg

Publikováno v: Asia-Pacific Journal of Clinical Oncology. 15:151-157

Background 5-Fluorouracil (5-FU) is administered with leucovorin (LV) to enhance clinical activity. However, simultaneous administration is not feasible due to their chemical incompatibility, so conditions for the maximum possible beneficial interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fac6155fd0fcfd3d7ad4dd30c21a806
https://doi.org/10.1111/ajco.13144

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Predicting 5-fluorouracil toxicity in colorectal cancer patients from peripheral blood cell telomere length: a multivariate analysis

Autor: Lisa F. Lincz, M B Garg, Jennette A. Sakoff, F. E. Scorgie, Stephen P. Ackland, K. Adler

Publikováno v: British Journal of Cancer

Background: Identifying various pretreatment factors that predict chemotherapy-induced toxicity in colorectal cancer (CRC) patients undergoing treatment for their disease is crucial to optimising patient care. Methods: Seventy-three patients received

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef50874e51bd1536d53afc2f4a069914
https://doi.org/10.1038/bjc.2012.421

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Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo

Autor: C E de Bock, Lisa F. Lincz, Jennette A. Sakoff, Stephen P. Ackland, N Scott, F. E. Scorgie, M B Garg

Publikováno v: The Pharmacogenomics Journal. 11:307-314

Two known polymorphisms in the 5' enhancer region (ER) of the thymidylate synthase (TS) gene, a variable number of tandem repeats of a 28 bp sequence (2R/3R) and a further G>C single nucleotide substitution within the repeats, result in genotypes wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b580727085ebe7372b7e6bbb95b06420
https://doi.org/10.1038/tpj.2010.43

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Phase I and pharmacokinetic study of docetaxel in combination with epirubicin and cyclophosphamide in advanced cancer: dose escalation possible with granulocyte colony-stimulating factor, but not with prophylactic antibiotics

Autor: Michael Millward, M B Garg, Joel Smith, Stephen Clarke, Danny Rischin, G. C. Toner, John Zalcberg, Stephen P. Ackland

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 13(11)

Background The objective of this phase I trial was to determine the maximally tolerated doses of the combination of docetaxel, epirubicin and cyclophosphamide. Patients and methods Patients with advanced cancer, World Health Organization (WHO) perfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bdeddc9da69ef3993f82c675422ac5
https://pubmed.ncbi.nlm.nih.gov/12419756

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234 Predicting Chemotherapy-induced Toxicity in Cancer Patients From Peripheral Blood Telomere Length

Autor: K. Adler, M B Garg, Stephen P. Ackland, Lisa F. Lincz, F. E. Scorgie, Jennette A. Sakoff

Publikováno v: European Journal of Cancer. 48:S57

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff5ecf20d0b624e7ffe77fcaace58ffb
https://doi.org/10.1016/s0959-8049(12)70929-2

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