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Importance of TNF production for the curative effectiveness of low dose melphalan therapy for mice bearing a large MOPC-315 tumor

Autor: L Gorelik, M Rubin, A Prokhorova, M B Mokyr

Publikováno v: The Journal of Immunology. 154:3941-3951

We have previously shown the importance of the acquisition of CD8+ T cell-dependent tumor-eradicating immunity for the curative effectiveness of low dose melphalan (L-PAM, L-phenylalanine mustard) for mice bearing a large MOPC-315 tumor. Here we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::357e4f512b7f43e353fa59a98a542b46
https://doi.org/10.4049/jimmunol.154.8.3941

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Insight into the mechanism of TCR-V beta 8+/CD8+ T cell-mediated MOPC-315 tumor eradication

Autor: M B Mokyr, A Prokhorova, M Rubin, J A Bluestone

Publikováno v: The Journal of Immunology. 153:3123-3134

We have previously shown that depletion of TCR-V beta 8+ T cells by treatment with mAb reduces the curative effectiveness of low dose melphalan (L-phenylalanine mustard; L-PAM) for mice bearing a large MOPC-315 tumor and extensive metastases. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6df6763d7e28de18b239bfe8c1738032
https://doi.org/10.4049/jimmunol.153.7.3123

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Cooperation between staphylococcal enterotoxin B and low dose melphalan in the cure of mice bearing a large MOPC-315 tumor and extensive metastases

Autor: M Rubin, J A Bluestone, K A Newell, A Prokhorova, M B Mokyr

Publikováno v: The Journal of Immunology. 152:3522-3529

We have recently demonstrated the importance of V beta 8+/CD8+ cells for the curative effectiveness of a suboptimal low dose (0.75 mg/kg) of melphalan (L-phenylalanine mustard; L-PAM) for mice bearing a large s.c. MOPC-315 tumor and extensive metasta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de6e3c2fb4199ae56529053e6216ed21
https://doi.org/10.4049/jimmunol.152.7.3522

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Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan

Autor: M B Mokyr, M Rubin, K A Newell, A Prokhorova, J A Bluestone

Publikováno v: The Journal of Immunology. 151:4838-4846

We have previously shown that the curative efficacy of low dose melphalan (L-phenylalanine mustard; L-PAM) for mice bearing a large s.c. MOPC-315 tumor requires the participation of CD8+ (but not CD4+) T cell-dependent antitumor immunity. Here we sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d9ac78c04cf5655cbd1465568cad47a
https://doi.org/10.4049/jimmunol.151.9.4838

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Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism

Autor: R N, La Motte, A H, Sharpe, J A, Bluestone, M B, Mokyr

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(8)

B7-1 (CD80)-transfected P815 tumor cells were previously shown to elicit tumor-eradicating immunity that leads to the regression of B7-1+ P815 tumors after transient growth in normal syngeneic (DBA/2) mice. Here, we show that not only the B7-1 molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b85e8618dc788fd2be3cbfff9d479e21
https://pubmed.ncbi.nlm.nih.gov/10202025

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Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells

Autor: R N, La Motte, A H, Sharpe, J A, Bluestone, M B, Mokyr

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(12)

We have previously shown that B7-2 (CD86)-transfected P815 tumor cells elicit tumor-eradicating immunity that leads to the regression of the B7-2+ P815 tumor after transient growth in normal DBA/2 mice. Here, we show that both the B7-2 and B7-1 (CD80

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e57993fbb6f15f037116c61149966a5
https://pubmed.ncbi.nlm.nih.gov/9862681

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Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice

Autor: M B, Mokyr, T, Kalinichenko, L, Gorelik, J A, Bluestone

Publikováno v: Cancer research. 58(23)

CTLA-4 blockade has been shown by other investigators [D. R. Leach, et al., Science (Washington DC), 271: 1734-1736, 1996; and Y-F. Yang, et al., Cancer Res., 57: 4036-4041, 1997] to retard tumor growth in selected tumor systems. Here, we show that C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2dbcf7dd3d92fde14e30ec4bfd0b09c8
https://pubmed.ncbi.nlm.nih.gov/9850053

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Insight into the mechanism(s) through which TNF promotes the generation of T cell-mediated antitumor cytotoxicity by tumor bearer splenic cells

Autor: L, Gorelik, Y, Bar-Dagan, M B, Mokyr

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 156(11)

We have shown previously that addition of TNF to stimulation cultures of MOPC-315 tumor bearer splenic cell suspensions containing metastatic tumor cells capable of secreting TGF-beta greatly enhances the generation of anti-MOPC-315 lytic activity by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbf742477cb20a422aafeb28f2342623
https://pubmed.ncbi.nlm.nih.gov/8666801

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Importance of TNF production for the curative effectiveness of low dose melphalan therapy for mice bearing a large MOPC-315 tumor

Autor: L, Gorelik, M, Rubin, A, Prokhorova, M B, Mokyr

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 154(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9bf90fd5e17616176ec394639f1e4ae
https://pubmed.ncbi.nlm.nih.gov/7706732

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