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Autor:
C M B Edwards
Publikováno v:
British Journal of Hospital Medicine. 74:198-201
This review discusses the rationale behind escalation of treatment for type 2 diabetes, and argues that after failure of oral medication the next logical treatment is a glucagon-like peptide-1 agonist.
Publikováno v:
The Journal of Physiology. 567:673-688
In sheep, direct fetal treatment with dexamethasone alters basal cardiovascular function and the cardiovascular response to acute hypoxaemia. However, in human clinical practice, dexamethasone is administered to the mother, not to the fetus. Hence, t
Publikováno v:
BJOG: An International Journal of Obstetrics and Gynaecology. 112:889-896
This study tested the hypothesis that pregnancy affects the cardiovascular responses to hypoxia by altering the outputs of the peripheral components of the stress system and independent of changes in P(a)CO(2).Comparison of cardiovascular and endocri
Autor:
S. J. O’Connor, P. D. Rossdale, N. B. Holdstock, Abigail L. Fowden, C. M. B. Edwards, J C Ousey, David S. Gardner, Dino A. Giussani
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 450:298-306
Objective: The aims of this study were to compare and contrast the development of the cardiac baroreflex and endocrine responses to acute hypotensive stress in healthy newborn pony foals and lambs during the first two weeks of postnatal life. Methods
Autor:
Stephen R. Bloom, Caroline R. Abbott, M. Rossi, Salah Abusnana, Min-Seon Kim, C. L. Dakin, K. G. Murphy, D. Sunter, Shahrad Taheri, C. M. B. Edwards
Publikováno v:
Brain Research. 866:128-134
The melanocortin-4 receptor (MC4-R) appears to be an important downstream mediator of the action of leptin. We examined to what extent the anorectic effects of cocaine- and amphetamine-regulated transcript (CART), glucagon-like peptide-1 (GLP-1) and
Autor:
M. A. Ghatei, S.R. Bloom, Sarah Stanley, S. Abusnana, David G.A. Morgan, C. M. B. Edwards, Caroline J. Small, Min Seon Kim, Wing May Kong, L. J. Seal, D. Sunter
Publikováno v:
Journal of Clinical Investigation. 105:1005-1011
Prolonged fasting is associated with a downregulation of the hypothalamo-pituitary thyroid (H-P-T) axis, which is reversed by administration of leptin. The hypothalamic melanocortin system regulates energy balance and mediates a number of central eff
Publikováno v:
Experimental Physiology. 84:1107-1113
The role of nitric oxide (NO) in mediating pancreatic endocrine responses to moderate hypoglycaemia has been investigated in conscious unrestrained calves. The synthesis of endogenous NO was inhibited by the administration of N -nitro-L-arginine meth
Publikováno v:
Journal of Endocrinology. 160:R7-12
Orexin-A and orexin-B (the hypocretins) are recently described neuropeptides suggested to have a physiological role in the regulation of food intake in the rat. We compared the orexigenic effect of the orexins administered intracerebroventricular (IC
Autor:
Anthony P. Goldstone, J. Steere, M. D. Turton, C. M. B. Edwards, M. Rossi, G. M. Taylor, Caroline J. Small, I. Gunn, Donal O'Shea, M. A. Ghatei, M. M. Heath, S.R. Bloom, Karim Meeran, S. Abusnana, D. Sunter, Sang Jeon Choi
Publikováno v:
Endocrinology. 140:244-250
Central nervous system glucagon-like peptide-1-(7–36) amide (GLP-1) administration has been reported to acutely reduce food intake in the rat. We here report that repeated intracerebroventricular (icv) injection of GLP-1 or the GLP-1 receptor antag