Zobrazeno 1 - 10
of 57
pro vyhledávání: '"M B, Brenner"'
Publikováno v:
The Journal of Immunology. 157:3366-3374
Intestinal mucosal lymphocytes are defined by their anatomic location within the epithelium (intraepithelial lymphocytes), the interstitium between the epithelial basement membrane and the underlying muscularis mucosa (lamina propria lymphocytes), or
Publikováno v:
International Immunology. 7:1681-1690
TGF-beta affects proliferation, differentiation and maturation of T cells; however, the effect of TGF-beta on thymic stromal cells has not been characterized. To better understand the role of TGF-beta in T cell development, we determined whether TGF-
Publikováno v:
The Journal of Immunology. 154:998-1006
The predominant subpopulation of gamma delta T cells in human peripheral blood expresses TCR V region genes V gamma 2 paired with V delta 2. Previous studies have shown that these V gamma 2V delta 2+ T cells proliferate in response to Daudi Burkitt l
Publikováno v:
The Journal of Immunology. 153:5133-5140
We examined the response of human gamma delta T cells to herpes simplex virus (HSV). PBMC from HSV seropositive individuals were stimulated with autologous HSV-infected PHA blasts. There was a 4- to 28-fold expansion of gamma delta T cells that were
Publikováno v:
The Journal of Immunology. 153:3979-3988
Little is known about the gamma delta T cells in human neonatal umbilical cord blood. To compare neonatal cord blood and adult blood gamma delta T cells, we studied the V gamma and V delta gene segment usage in these populations by flow cytometry, an
Publikováno v:
The Journal of Immunology. 150:3459-3470
Intestinal intraepithelial lymphocytes (iIEL) are a distinct subpopulation of T lymphocytes diffusely distributed in the epithelium. Because > 95% of these iIEL express the integrin alpha E beta 7, we reasoned that this integrin might mediate the loc
Publikováno v:
The Journal of Immunology. 147:3360-3369
Little is known about the nature of Ag recognition by the TCR-gamma delta. The recent observation that gamma delta T cells preferentially recognize mycobacterial Ag provides a model to examine the molecular basis of gamma delta-TCR recognition. Here,
Publikováno v:
The Journal of Immunology. 144:1120-1126
Specific TCR V gamma and V delta segments are found to be coordinately used on subpopulations of gamma delta T lymphocytes. The reasons for this phenomenon are unknown, but may include the inability of particular chains expressing unique V delta and
Autor:
C M Parker, V Groh, H Band, S A Porcelli, C Morita, M Fabbi, D Glass, J L Strominger, M B Brenner
Publikováno v:
The Journal of Experimental Medicine
The germline repertoire of variable genes for the TCR-gamma/delta is limited. This, together with the availability of several V delta-specific and a C delta-specific mAbs, has made it possible to assess differences in the TCR-gamma/delta repertoire i
Publikováno v:
European journal of immunology. 30(11)
Gangliosides form a component of the glycosphingolipid-rich membrane microdomains recently shown to play an important role in receptor signal transduction. Specific gangliosides also serve as receptors for binding and internalization of bacterial tox