Výsledky vyhledávání

Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells

Autor: S K, Basu, I S, Haworth, M B, Bolger, V H, Lee

Publikováno v: Investigative ophthalmologyvisual science. 39(12)

To characterize proton-driven carrier-mediated dipeptide uptake in primary cultured conjunctival epithelial cells of the pigmented rabbit using beta-alanyl-L-histidine (L-carnosine) as a model dipeptide substrate.Uptake of tritiated L-carnosine was m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25193aca194d32b0eb3ddcc7240cf73d
https://pubmed.ncbi.nlm.nih.gov/9804145

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In vitro and in vivo activity of 16,17-dehydro-epipregnanolones: 17,20-bond torsional energy analysis and D-ring conformation

Autor: M B, Bolger, S, Wieland, J E, Hawkinson, H, Xia, R, Upasani, N C, Lan

Publikováno v: Pharmaceutical research. 13(10)

Certain neuroactive pregnane steroids (also known as "epalons") are allosteric modulators of the GABA, receptor and have been shown to be potent anticonvulsants, anxiolytics, sedative/hypnotics, and anesthetic agents. The purpose of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6fde8e20737cd7523cfa3ee770b34165
https://pubmed.ncbi.nlm.nih.gov/8899839

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Low level hyperbaric antagonism of diazepam's locomotor depressant and anticonvulsant properties in mice

Autor: D L, Davies, M, Bejanian, E S, Parker, J, Mørland, M B, Bolger, R D, Brinton, R L, Alkana

Publikováno v: The Journal of pharmacology and experimental therapeutics. 276(2)

Exposure to 12 atmospheres absolute (12 ATA) helium oxygen gas (heliox) (low level hyperbaric exposure) antagonizes the behavioral effects of ethanol and n-propanol, but not morphine. These and other results indicate that the mechanism of the antagon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39bd8e7409c0d8771dd27d14351b51eb
https://pubmed.ncbi.nlm.nih.gov/8632335

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Pharmacology of a GABAA receptor coupled steroid recognition site

Autor: K W, Gee, N C, Lan, M B, Bolger, S, Wieland, D, Belelli, J S, Chen

Publikováno v: Advances in biochemical psychopharmacology. 47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2599429f033c62e0080375ea2d5e3645
https://pubmed.ncbi.nlm.nih.gov/1354914

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Computer modeling of combining site structure of anti-hapten monoclonal antibodies

Autor: M B, Bolger, M A, Sherman

Publikováno v: Methods in enzymology. 203

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7751c94474ad6e2f0b6a4b1452144473
https://pubmed.ncbi.nlm.nih.gov/1762557

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Analysis of idiotypic and anti-idiotypic antibodies as models of receptor and ligand

Autor: M B Bolger, P. H. Kussie, Dario Marchetti, S Combs, D. S. Linthicum, T A Linton, G M Albright

Publikováno v: Clinical Chemistry. 34:1676-1680

Antibodies to small bioactive ligands and peptides may mimic the binding characteristics of the natural receptor; in turn, the anti-idiotypic antibodies generated against the binding sites of such anti-ligand antibodies may mimic some aspects of smal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99b9bc3ffedcef37ff8c64950e3709f9
https://doi.org/10.1093/clinchem/34.9.1676

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Molecular interactions between thyroid hormone analogs and the rat liver nuclear receptor. Partitioning of equilibrium binding free energy changes into substituent group interactions

Autor: E C Jorgensen, M B Bolger

Publikováno v: Journal of Biological Chemistry. 255:10271-10278

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f8144f9ca3ae03d16ac35c7d4aead17
https://doi.org/10.1016/s0021-9258(19)70460-8

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Interaction of yeast transcription factor IIIC with dimeric Schizosaccharomyces pombe tRNASer-tRNAMet genes

Autor: M Nichols, M B Bolger, Deborah L. Johnson, Samuel H. Wilson

Publikováno v: Journal of Biological Chemistry. 264:19221-19227

A unique tRNA(Ser)-tRNA(Met) tandem gene arrangement was characterized previously from Schizosaccharomyces pombe. Three alleles exist in which a tRNA(Ser) gene is separated by 7 base pairs from an initiator tRNA(Met) gene. Promotion of transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51af430f3c87fc57835c68db6d51e2ec
https://doi.org/10.1016/s0021-9258(19)47290-6

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Haloperidol binding to monoclonal antibodies. Hypervariable region amino acid sequence determination

Autor: R J Deans, M A Sherman, M B Bolger

Publikováno v: Journal of Biological Chemistry. 263:4059-4063

The primary sequences of five monoclonal antibodies (mAbs A-E) which bind with various affinities (Kd = 4-810 nM) to the D-2 dopaminergic antagonist, haloperidol, have been determined. Immunoglobulin light and heavy chain mRNA was isolated and gene s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3990ea01e5451335c6e544cb7bccf43
https://doi.org/10.1016/s0021-9258(18)68890-8

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Haloperidol binding to monoclonal antibodies. Predictions of three-dimensional combining site structure via computer modeling

Autor: M A Sherman, M B Bolger

Publikováno v: Journal of Biological Chemistry. 263:4064-4074

The amino acid sequences of five monoclonal antibodies (designated mAbs A-E) which bind to the dopaminergic D-2 antagonist, haloperidol, with a variety of affinities (Kd = 4-810 nM), have been used to build theoretical, three-dimensional, computer mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdbd28b5984d4c6c8b381589e5d2d788
https://doi.org/10.1016/s0021-9258(18)68891-x

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