Zobrazeno 1 - 10
of 14
pro vyhledávání: '"M B, Affrime"'
Publikováno v:
Pharmaceutical research. 17(10)
To evaluate covariate effects on the pharmacokinetics of temozolomide in cancer patients, and to explore the dose-pharmacokinetics-toxicity relationship of temozolomide.Non-linear mixed-effects modeling approach was used to analyze the data from 445
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3d48f3c6979279344c6d40e08bc8ceb
https://pubmed.ncbi.nlm.nih.gov/11145236
https://pubmed.ncbi.nlm.nih.gov/11145236
Autor:
M B, Affrime, F, Cuss, D, Padhi, M, Wirth, S, Pai, R P, Clement, J, Lim, B, Kantesaria, K, Alton, M N, Cayen
Publikováno v:
Journal of clinical pharmacology. 40(11)
These studies were conducted to assess the systemic bioavailability of mometasone furoate (MF) administered by both the dry-powder inhaler (DPI) and the metered-dose inhaler with an alternate propellant (MDI-AP). The pharmacokinetics of single doses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28a38d70599107ec595ef3e0edbd69ea
https://pubmed.ncbi.nlm.nih.gov/11075308
https://pubmed.ncbi.nlm.nih.gov/11075308
Publikováno v:
Pharmaceutical research. 15(12)
To study the pharmacokinetics and ex vivo leukocyte responses of recombinant human IL-10 (rHuIL-10) following single s.c. and i.v. dosing.A randomized two-way cross-over study was undertaken in 17 healthy volunteers in which rHuIL-10 was administered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fb04299b7583e682a18729d26819f13
https://pubmed.ncbi.nlm.nih.gov/9892475
https://pubmed.ncbi.nlm.nih.gov/9892475
Autor:
D, Pajkrt, L, Camoglio, M C, Tiel-van Buul, K, de Bruin, D L, Cutler, M B, Affrime, G, Rikken, T, van der Poll, J W, ten Cate, S J, van Deventer
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 158(8)
To determine the effects of IL-10 on cytokine and granulocyte responses during endotoxemia, two groups of eight healthy male volunteers were challenged with endotoxin (4 ng/kg) on two occasions, once in combination with placebo injection, and once in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::810c7f391f15d9c0129cfdafcd20f9fa
https://pubmed.ncbi.nlm.nih.gov/9103468
https://pubmed.ncbi.nlm.nih.gov/9103468
Autor:
D, Pajkrt, T, van der Poll, M, Levi, D L, Cutler, M B, Affrime, A, van den Ende, J W, ten Cate, S J, van Deventer
Publikováno v:
Blood. 89(8)
Interleukin-10 (IL-10) has been found to inhibit lipopolysaccharide (LPS)-induced tissue factor expression by monocytes in vitro. To determine the effects of IL-10 on LPS-induced activation of the hemostatic mechanisms in vivo, we performed a placebo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc448b94d44e947d85d8d4e2b5689752
https://pubmed.ncbi.nlm.nih.gov/9108387
https://pubmed.ncbi.nlm.nih.gov/9108387
Publikováno v:
Pharmacotherapy. 17(1)
To compare the pharmacokinetics of ceftibuten, cefixime, ceturoxime axetil, and cefaclor after oral administration.Randomized, four-period, crossover study.Hospital-based clinical research center.Healthy adult men and women volunteers.Single 400-mg d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a4b141c1e21c819a14b11397dd6aa69
https://pubmed.ncbi.nlm.nih.gov/9017772
https://pubmed.ncbi.nlm.nih.gov/9017772
Autor:
R D, Huhn, E, Radwanski, S M, O'Connell, M G, Sturgill, L, Clarke, R P, Cody, M B, Affrime, D L, Cutler
Publikováno v:
Blood. 87(2)
Normal volunteers received single doses of recombinant human interleukin-10 (rhIL-10; n = 6 per group) or placebo (n = 3 per group) by intravenous injection to characterize pharmacokinetics, tolerability, and immunomodulatory effects. Dosages were 0.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1daf5a02a65b5cbb4631d968a8ed990
https://pubmed.ncbi.nlm.nih.gov/8555493
https://pubmed.ncbi.nlm.nih.gov/8555493
Autor:
B, Oosterhuis, M D, Brannan, H, Groen, P A, Peeters, J, Hempenius, E, Radwanski, A A, Nomeir, M B, Affrime, J H, Jonkman
Publikováno v:
Annals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology. 75(2)
There is a close relationship between improvement in airway function and the plasma concentration of theophylline, as well as between rapidly rising plasma theophylline concentrations and increased frequency of undesired effects. Development of pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26ff3280181741655f3d55467e5dc127
https://pubmed.ncbi.nlm.nih.gov/7648380
https://pubmed.ncbi.nlm.nih.gov/7648380
Autor:
W H, Barr, R, Colucci, E, Radwanski, N, Zampaglione, D, Cutler, C C, Lin, M, Elliott, M B, Affrime
Publikováno v:
Journal of chemotherapy (Florence, Italy). 7
Isepamicin is a new aminoglycoside that has activity against many bacteria resistant to other aminoglycosides. The pharmacokinetics of isepamicin have been characterized in neonatal, pediatric, adult, elderly and renally impaired human populations as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dac38abf517f18cff84d489f71fd8705
https://pubmed.ncbi.nlm.nih.gov/8622111
https://pubmed.ncbi.nlm.nih.gov/8622111
Autor:
C E Halstenson, M O Wong, C S Herman, K L Heim-Duthoy, M A Teal, M B Affrime, J H Kelloway, W F Keane, W M Awni
Publikováno v:
Antimicrobial agents and chemotherapy. 36(9)
Piperacillin inactivation of the aminoglycosides isepamicin and gentamicin in 12 chronic hemodialysis patients was assessed. Six subjects each received isepamicin (7.5 mg/kg of body weight) or gentamicin (2 mg/kg) alone and in combination with pipera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d5b1066b049fcf72f90ee4cdb59b85
https://pubmed.ncbi.nlm.nih.gov/1416875
https://pubmed.ncbi.nlm.nih.gov/1416875