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Akademický článek
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Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(8)
To investigate the modulatory role of IFN-gamma on the induction and maintenance of Th2 mucosal immunity in vivo, experiments were performed in mice lacking the IFN-gamma R. Aerosol OVA challenge of immunized wild-type mice resulted in an infiltratio
Autor:
B D, Car, V M, Eng, B, Schnyder, M, LeHir, A N, Shakhov, G, Woerly, S, Huang, M, Aguet, T D, Anderson, B, Ryffel
Publikováno v:
The American journal of pathology. 147(6)
Interleukin 12 (IL-12) activates natural killer (NK) and T cells with the secondary synthesis and release of interferon-gamma (IFN-gamma) and other cytokines. IL-12-induced organ alterations are reported for mice and the pathogenetic role of IFN-gamm
Publikováno v:
Kidney international. 48(6)
MHC class II gene products in parenchymal cells, such as tubular epithelial cells in kidney, may play a role in the regulation of autoimmune reactions. Expression of MHC class II in renal tubular cells is normally very low, but it increases considera
Autor:
P, Matthys, G, Froyen, L, Verdot, S, Huang, H, Sobis, J, Van Damme, B, Vray, M, Aguet, A, Billiau
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 155(8)
Mice with a disruption of the IFN-gamma receptor alpha-chain gene (IFN-gamma R alpha o/o mice) were found to be significantly more sensitive than their wild-type counterparts to induction of the anti-CD3-induced disease syndrome. Specifically, when g
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 154(10)
IFN-gamma receptor deficient (IFN-gamma R-/-) mice, immunized with different developmental stages of malaria parasites, were used to define the mechanisms of protection against the various stages of this infection. IFN-gamma R-/- mice failed to devel
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 154(6)
In healthy mice, murine (m) TNF is fairly lethal, whereas human (h) TNF (a selective murine TNF-R55 agonist) is rather harmless. However, we and others observed that mice suffering from a bacterial infection, such as Bacillus Calmette-Guérin (BCG),
Publikováno v:
Journal of inflammation. 46(1)
Mice with a targeted deletion of either the interferon (IFN)-gamma gene or the IFN-gamma receptor gene (IFN-gamma R(0/0) mice) fail to survive infection with the Bacillus Calmette-Guerin (BCG) strain of Mycobacterium bovis. Here we show that resident
Publikováno v:
Developments in biological standardization. 80