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Intramolecular diels-alder reactions.4. Additions to naphthalene

Autor: M. A. Wuonola, Richard L. Harlow, Engelbert Ciganek

Publikováno v: Journal of Heterocyclic Chemistry. 31:1251-1257

N-Methyl-N-2-propynyl-1-naphthalenecarboxamide, N-methyl-N-2-propynyl-1-naphthaleneacetamide, and N-methyl-N-3-butynyl-1-naphthalenecarboxamide undergo intramolecular Diels-Alder reactions at 190°, 250°, and 270° to give lactams 1,6, and 9, respec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e21ecba2b660bfae4f7c7f7e8e0b3f9d
https://doi.org/10.1002/jhet.5570310523

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Synthesis and anti-HIV Activity of a Series of 2-Indolinones and Related Analogues

Autor: J. M. Smallheer, M. A. Wuonola, M. J. Otto, P. Pennev, David C. Montefiori, Carol Amaral-Ly, M. J. Myers, Richard A. Earl

Publikováno v: Antiviral Chemistry and Chemotherapy. 4:27-39

A novel series of 2-indolinones with in vitro anti-HIV (human immunodeficiency virus) activity is described. Two structurally related compounds, 1, 3,3-(4- N-methyl-1,2,5,6-tetrahydropyridylmethyl)-1- phenyl-2-indolinone, and 2, its 4- N-methylpiperi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b2f08908be7cf51975f3991b06ed9d9
https://doi.org/10.1177/095632029300400104

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ChemInform Abstract: Synthesis of 1,5-Dimethyl-1,4-dihydropyrrolo(3,4-b)pyrrol-6(5H)-one by Intramolecular Diels-Alder Reaction to the Imidazole Nucleus

Autor: M. A. Wuonola, Joanne M. Smallheer

Publikováno v: ChemInform. 24

N-Methyl-N-propargylimidazole-5-carboxamide undergoes thermal intramolecular Diels-Alder reaction to give the title compound. A related reaction of the corresponding sydnone system is also described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bdeb52917b2dfec86fd14d5736c8ff5
https://doi.org/10.1002/chin.199309153

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Acetylcholine-releasing agents as cognition enhancers. Structure-activity relationships of pyridinyl pendant groups on selected core structures

Autor: Victor Johannes Nickolson, George A. Boswell, Rouxi Lan, Leonard Cook, S. William Tam, Alexander L. Johnson, Robert J. Chorvat, Xusheng Zhang, Chuan Wang, Richard M. Scribner, Richard A. Earl, Hua Wenting, Baoyu Mi, Wendell Wilkie Wilkerson, Robert Zaczek, Melvyn John Myers, M. A. Wuonola, David R. Brittelli

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 2:851-854

A number of analogs of the cognition enhancing agent DuP 996 were prepared by varying the core structure and pendant groups in an independent fashion. The SAR of 2-, 3-, and 4-pyridinylmethyl groups as pendant groups on selected cores was examined.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c365fa994339b469a0af6b63ca639a03
https://doi.org/10.1016/s0960-894x(00)80543-0

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DuP 747: sar study

Autor: C.Y. Cheng, S.W. Tam, Parthasarathi Rajagopalan, Hollis Smith Kezar, Alexander L. Johnson, G.F. Steinfels, P.L. Mattei, Richard Merrill Scribner, R.S. Cheeseman, Penio Pennev, M. A. Wuonola, William K. Schmidt, V.R. Ganti, Leonard Cook

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 2:721-726

The results of a detailed study of the structure-activity relationships in the series of compounds represented by DuP 747 are described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87f258131d4f138c2e3598366629bd21
https://doi.org/10.1016/s0960-894x(00)80399-6

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Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 4. Multiply-substituted aryl derivatives

Autor: Ronald J. McRipley, Andrew M. Slee, Frank D. Marsh, Virginia S. Eberly, David R. Brittelli, M. A. Wuonola, Chung Ho Park, Martin Forbes, Wang Chia-Lin Jeffrey, Walter Adelman Gregory

Publikováno v: Journal of Medicinal Chemistry. 35:1156-1165

The synthesis and structure-activity relationship (SAR) studies of the effect of different polysubstitution patterns in the aromatic ring of 5-(acetamidomethyl)oxazolidinone antibacterials (I) on antibacterial activity are presented. Compounds I were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557089b2434c915f304341413cc7222e
https://doi.org/10.1021/jm00084a022

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Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 2. The 'A' group

Autor: D. C. Eustice, Chia-Lin J. Wang, P. T. Bartholomew, M. Forbes, David R. Brittelli, Andrew M. Slee, M. A. Wuonola, R. J. Mcripley, W. A. Gregory, V. S. Eberly

Publikováno v: Journal of Medicinal Chemistry. 33:2569-2578

The synthesis and structure-activity relationship (SAR) studies of the effect of varying the "A" group in a series of 5-(acetamidomethyl)oxazolidonone antibacterials (2) are described. Compounds 2 were principally prepared either by the six-step synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ae7d5de14ba9bd56c9ab466850c168
https://doi.org/10.1021/jm00171a035

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