Zobrazeno 1 - 10
of 59
pro vyhledávání: '"M A Westcott"'
Autor:
Rupesh S. Patel, Rodrigo Romero, Emma V. Watson, Anthony C. Liang, Megan Burger, Peter M. K. Westcott, Kim L. Mercer, Roderick T. Bronson, Eric C. Wooten, Arjun Bhutkar, Tyler Jacks, Stephen J. Elledge
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
GATA-binding protein 4 (GATA4) is reported to control cell proliferation in cancers. Here the authors show that GATA4’s pro-inflammatory secretome promotes the recruitment of immune cells such as CD8 + T cells to suppress tumour initiation and grow
Externí odkaz:
https://doaj.org/article/0f7b65b8712445b997f900c25649c681
Autor:
Wei-Ching Chen, Minh D. To, Peter M. K. Westcott, Reyno Delrosario, Il-Jin Kim, Mark Philips, Quan Tran, Saumya R. Bollam, Hani Goodarzi, Nora Bayani, Olga Mirzoeva, Allan Balmain
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Kras is frequently mutated in lung cancer and two isoforms are generated via alternative splicing. Here, the authors show that the two isoforms have divergent roles in cancer stem cells and the main tumour cell population, which are regulated by hypo
Externí odkaz:
https://doaj.org/article/a22b5d5de40945018011a5128be0357a
Autor:
Zackery A. Ely, Nicolas Mathey-Andrews, Santiago Naranjo, Samuel I. Gould, Kim L. Mercer, Gregory A. Newby, Christina M. Cabana, William M. Rideout, Grissel Cervantes Jaramillo, Jennifer M. Khirallah, Katie Holland, Peyton B. Randolph, William A. Freed-Pastor, Jessie R. Davis, Zachary Kulstad, Peter M. K. Westcott, Lin Lin, Andrew V. Anzalone, Brendan L. Horton, Nimisha B. Pattada, Sean-Luc Shanahan, Zhongfeng Ye, Stefani Spranger, Qiaobing Xu, Francisco J. Sánchez-Rivera, David R. Liu, Tyler Jacks
Publikováno v:
Nature Biotechnology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae1a4aa0f1935d98be9c88b1dc7016f7
https://doi.org/10.1038/s41587-023-01783-y
https://doi.org/10.1038/s41587-023-01783-y
Autor:
Alex M. Jaeger, JJ Patten, Olivia Smith, Haley Hauck, Ömer H. Yilmaz, Tyler Jacks, George Eng, Peter M. K. Westcott, Jason M. Schenkel, Coralie Backlund, Ryan Elbashir, Darrell J. Irvine, Zackery A. Ely, Daniel Zhang, Nathan J. Sacks, Mary Clare Beytagh
Publikováno v:
Nature Cancer. 2:1071-1085
Immune evasion is a hallmark of cancer and therapies that restore immune surveillance have proven highly effective in cancers with high tumor mutation burden (TMB) (for example, those with microsatellite instability). Whether low TMB cancers, which a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4273c6894f082d2418205f8f333ecec5
https://doi.org/10.1038/s43018-021-00247-z
https://doi.org/10.1038/s43018-021-00247-z
Autor:
Alex M. Jaeger, Lauren E. Stopfer, Ryuhjin Ahn, Emma A. Sanders, Demi A. Sandel, William A. Freed-Pastor, William M. Rideout, Santiago Naranjo, Tim Fessenden, Kim B. Nguyen, Peter S. Winter, Ryan E. Kohn, Peter M. K. Westcott, Jason M. Schenkel, Sean-Luc Shanahan, Alex K. Shalek, Stefani Spranger, Forest M. White, Tyler Jacks
Publikováno v:
Nature
Immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex class I (MHC-I)(1,2,3,4,5). Current approaches to profile MHC-I associated peptides, collectively known as the “immunopeptidome”, are l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c592d9e991788f10c2d2d6252e7d29e
https://europepmc.org/articles/PMC9945857/
https://europepmc.org/articles/PMC9945857/
Autor:
Caterina I. Colón, Mary Clare Beytagh, Alexander Muir, Francisco J. Sánchez-Rivera, Santiago Naranjo, Kim L. Mercer, Tania J. González Robles, Matthew G. Vander Heiden, Peter M. K. Westcott, Swanny Lamboy Rodríguez, Sheng Rong Ng, Tyler Jacks, Roderick T. Bronson, Caroline A. Lewis, Laura Z. Liao, Arjun Bhutkar, Peggy P. Hsu, Rodrigo Romero, Leanne Li
Publikováno v:
Nat Cancer
Approximately 20-30% of human lung adenocarcinomas (LUAD) harbor loss-of-function (LOF) mutations in Kelch-like ECH Associated-Protein 1 (KEAP1), which lead to hyperactivation of the nuclear factor, erythroid 2-like 2 (NRF2) antioxidant pathway and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e499f9f0f0ccf74861bc3b6657ae95
https://doi.org/10.1038/s43018-020-0071-1
https://doi.org/10.1038/s43018-020-0071-1
Autor:
Carla P. Concepcion, Francisco J. Sánchez-Rivera, Isabella Del Priore, Jonathan Y. Kim, Lindsay M. LaFave, Natasha Rekhtman, Carla F. Kim, Vinay K. Kartha, Jason D. Buenrostro, Aviv Regev, Adam J. Schoenfeld, Lydia P. DeAngelo, Gregory J. Riely, Arjun Bhutkar, Manav Gupta, Tyler Jacks, Roderick T. Bronson, Manon Miller, Charles M. Rudin, Manyuan Liu, Kevin Meli, Peter M. K. Westcott, Sai Ma
Publikováno v:
Cancer Discov
SMARCA4/BRG1 encodes for one of two mutually exclusive ATPases present in mammalian SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung adenocarcinoma. However, the functional consequences of SMARCA4 mutation on tumor initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c506ed31ff932bcf656a7974f62fa6
https://europepmc.org/articles/PMC8831463/
https://europepmc.org/articles/PMC8831463/
Autor:
Jason M. Schenkel, Sara Z. Tavana, Michelle Hillman, Peter M. K. Westcott, Megan L. Burger, Sarah E. Blatt, Tyler Jacks, David Canner, Marta M. Holovatska, Michael Manos, Giorgio Gaglia, Izumi de los Rios Kobara, Aviv Regev, Alex M. Jaeger, Arjun Bhutkar, Sandro Santagata, William L. Hwang, F. Stephen Hodi, Cecily C. Ritch, Amanda M. Cruz, Tamina Kienka, Andrea Garmilla, Alexia L. Barandiaran, Amy Li, Grace E. Crossland
Publikováno v:
Cell
Summary CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about the interplay between responses and its impact on T cell function and tumor control. In mouse lung adenocarcinoma, we found that immunodo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881da5a74e035825ca947128bb7a8b0b
https://europepmc.org/articles/PMC8522630/
https://europepmc.org/articles/PMC8522630/
Autor:
William L. Hwang, Megan L. Burger, Orit Rozenblatt-Rosen, Le Cong, Michael S. Cuoco, Tyler Jacks, Jonathan Y. Kim, David Canner, George Eng, Amy Li, Sean-Luc Shanahan, Peter M. K. Westcott, Olivia Smith, Patricia Rogers, Rebecca H. Herbst, Kristen E. Pauken, Grace Gibbons, Aviv Regev, Jason M. Schenkel, Jin K. Park, Michelle Hillman, William A. Freed-Pastor
Publikováno v:
Immunity
In tumors, a subset of CD8(+) T cells expressing the transcription factor TCF-1 drives the response to immune checkpoint blockade. We examined the mechanisms that maintain these cells in an autochthonous model of lung adenocarcinoma. Longitudinal sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4e9ed93c4fcd85dd5b84259ce61603
https://europepmc.org/articles/PMC8604155/
https://europepmc.org/articles/PMC8604155/
Autor:
Alex M. Jaeger, David Canner, Mary Clare Beytagh, JJ Patten, William M. Rideout, Haley Hauck, Isidro Cortes-Ciriano, Santiago Naranjo, Abbey Jin, Zackery A. Ely, Tyler Jacks, Nathan J. Sacks, Roderick T. Bronson, Peter M. K. Westcott, Francesc Muyas, Arjun Bhutkar, Olivia Smith, Daniel Zhang, Amanda M. Cruz
DNA mismatch repair deficiency (MMRd) is associated with high tumor mutational burden (TMB), increased T cell infiltration, and remarkable responsiveness to immune checkpoint blockade (ICB) therapy1. Nevertheless, about half of MMRd tumors do not res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f615eadc4d03bce6cde32dfce858f582
https://doi.org/10.21203/rs.3.rs-879464/v1
https://doi.org/10.21203/rs.3.rs-879464/v1