Zobrazeno 1 - 10
of 133
pro vyhledávání: '"M A Vadas"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1518:57-62
Sequencing of rat and human vascular endothelial growth factor (VEGF) cDNA clones has previously identified a 3' untranslated region of approximately 1.9 kb, although the apparent site of polyadenylation differed in the two species, despite a high de
Publikováno v:
The Journal of Immunology. 157:360-368
A central mechanism of inflammation is the activation of vascular endothelium by the inflammatory cytokines TNF-alpha and IL-1. These cytokines induce the expression of adhesion molecules, the elaboration of chemokines, and the transendothelial migra
Publikováno v:
The Journal of Immunology. 153:3199-3209
P-selectin is an adhesion molecule for myeloid cells that seems to be essential for the development of cellular inflammatory responses. We show that adhesion of neutrophils to purified and recombinant P-selectin enhances the phagocytosis of unopsoniz
Publikováno v:
Scopus-Elsevier
The effects of recombinant interleukin 4 (IL-4) on cell cluster and multinucleated giant cell (MGC) formation from human immunodeficiency virus (HIV)-infected and uninfected monocytes were examined. Human blood monocytes were isolated by centrifugal
Autor:
Joanna M. Woodcock, Mara Dottore, Christopher J. Bagley, Bronwyn Cambareri, M F Shannon, T R Hercus, Angel F. Lopez, M A Vadas
Publikováno v:
Proceedings of the National Academy of Sciences. 91:5838-5842
Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic hemopoietic growth factor and activator of mature myeloid cell function. We have previously shown that residue 21 in the first helix of GM-CSF plays a critical role in b
Publikováno v:
Blood. 83:2469-2479
Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor produced by mesenchymal and myeloid cells following activation by inflammatory stimuli. It has previously been shown that a region of the G-CSF promoter, (-200 to -165) co
Autor:
Bronwyn Cambareri, Christopher J. Bagley, M F Shannon, Paul A.B. Moretti, J. A. Phillips, Simon C. Barry, Gregory J. Goodall, Richard J D'Andrea, Mara Dottore, M A Vadas
Publikováno v:
Journal of Biological Chemistry. 269:8488-8492
We have previously reported that the predicted first helix of human interleukin (IL)-3 contains a hydrophilic region encompassing residues Asp21, Glu22, and Thr25 that is crucial for biological activity and IL-3 receptor binding. Using single amino a
Autor:
Peter Vandenabeele, X. Van Ostade, W B Smith, J. Barbara, J R Gamble, Walter Fiers, Angel F. Lopez, M A Vadas, Jan Tavernier
Publikováno v:
The EMBO Journal. 13:843-850
Human tumour necrosis factor alpha (TNF-alpha) is a pleiotropic cytokine capable of killing mammalian tumour cells in vitro and in vivo, and of enhancing the proinflammatory activity of leucocytes and endothelium, the latter effects limiting its usag
Publikováno v:
The Journal of Immunology. 150:4494-4503
Transforming growth factor-beta (TGF-beta), a pleiotropic cytokine that is elaborated in the active form upon co-culture of endothelial cells and pericytes or smooth muscle cells, has been shown to decrease the adhesiveness of endothelial cells for n
Autor:
Bronwyn Cambareri, P. Simmons, Angel F. Lopez, M A Vadas, J. A. Phillips, M F Shannon, Mara Dottore, Simon C. Barry
Publikováno v:
Scopus-Elsevier
Human interleukin 3 (IL-3) variants generated by site-directed mutagenesis were analyzed in multiple biological and binding assays to identify residues critical for IL-3 activity. Two mutants carrying substitutions in the predicted hydrophilic region