Výsledky vyhledávání - "M A T M van Vugt"

The 27th Annual Meeting of the Japanese Society for Pigment Cell Research

Autor: Thijs T Wind, Christian U. Blank, E.G.E. de Vries, Geke A. P. Hospers, J.J. De Haan, Rudolf S N Fehrmann, Mathilde Jalving, M A T M van Vugt, R van Rijn, Dirk-Jan Reijngoud

Publikováno v: Pigment Cell & Melanoma Research. 30:157-171

Despite new treatment options, prognosis of many melanoma patients remains poor and new treatment strategies are still needed. Stratification in molecular subclasses may aid therapeutic development. Therefore, we performed consensus clustering of 405

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e0728f9230e0f68c16a656fa1b4e4c9
https://doi.org/10.1111/pcmr.12555

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A randomized phase II study investigating the addition of the specific COX-2 inhibitor celecoxib to docetaxel plus carboplatin as first-line chemotherapy for stage IC to IV epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas: the DoCaCel study

Autor: H. de Graaf, M. Polee, Anna K.L. Reyners, Willem M. Smit, A.N.M. Wymenga, Pax H.B. Willemse, Frans L. G. Erdkamp, M A T M van Vugt, Roy I. Lalisang, L. de Munck, K. Hoekman, Michael Schaapveld, Harry Hollema

Publikováno v: Annals of Oncology, 23(11), 2896-2902. Oxford University Press
Reyners, A K L, de Munck, L, Erdkamp, F L G, Smit, W M, Hoekman, K, Lalisang, R I, de Graaf, H, Wymenga, A N M, Polee, M, Hollema, H, van Vugt, M A T M, Schaapveld, M & Willemse, P H B 2012, ' A randomized phase II study investigating the addition of the specific COX-2 inhibitor celecoxib to docetaxel plus carboplatin as first-line chemotherapy for stage IC to IV epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas: the DoCaCel study ', Annals of Oncology, vol. 23, no. 11, pp. 2896-2902 . https://doi.org/10.1093/annonc/mds107

In ovarian cancer, cyclooxygenase-2 (COX-2) overexpression is prognostic for poor survival. We investigated the efficacy of celecoxib (C), a selective COX-2 inhibitor, added to docetaxel (Taxotere)/carboplatin (DC) in advanced ovarian cancer.In a pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9feaf5205ed72630763bee110dca8b9a
https://hdl.handle.net/1871/42345

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ATR inhibition preferentially targets homologous recombination-deficient tumor cells

Autor: Małgorzata Krajewska, Lude Franke, Pepijn M Schoonen, S Labib, E.G.E. de Vries, M A T M van Vugt, Rudolf S N Fehrmann

Publikováno v: ONCOGENE, 34(26), 3474-3481. Nature Publishing Group
Europe PubMed Central

Homologous recombination (HR) is required for faithful repair of double-strand DNA breaks. Defects in HR repair cause severe genomic instability and challenge cellular viability. Paradoxically, various cancers are HR defective and have apparently acq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b7d3938bb79d6806a2204c2a97e1d8
https://pubmed.ncbi.nlm.nih.gov/25174396

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Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination

Autor: Małgorzata Krajewska, Renée I. Seinstra, M A T M van Vugt, Yvette Bisselink, E.G.E. de Vries, Anne Margriet Heijink, Herman H W Silljé

Publikováno v: ONCOGENE, 32(24), 3001-3008. Nature Publishing Group

In response to DNA breaks, the 'DNA damage response' provokes a cell cycle arrest to facilitate DNA repair. Recent findings have indicated that cells can respond to DNA damage throughout the cell cycle, except during mitosis. Specifically, various mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639fa861ac2bc95e94b37de702491474
https://research.rug.nl/en/publications/4ad66702-35e9-4dfb-bc1d-157cdef8e78a