Výsledky vyhledávání - "M A R Shiner"

Synthesis and Structure−Activity Relationships of Cetiedil Analogues as Blockers of the Ca2+-Activated K+ Permeability of Erythrocytes

Autor: M Malik-Hall, Athmani S, Wilma Quaglia, Charon Robin Ganellin, M A R Shiner, David C. H. Benton, Bisi A, D.G. Haylett, D. H. Jenkinson, Craig J. Roxburgh

Publikováno v: Journal of Medicinal Chemistry. 44:3244-3253

Cetiedil, [2-cyclohexyl-2-(3-thienyl)ethanoic acid 2-(hexahydro-1H-azepin-1-yl)ethyl ester], which blocks the intermediate calcium-activated potassium ion permeability (IK(Ca)) in red blood cells, was used as a lead for investigating structure-activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec387e13244d64970259c8cbdb447e6
https://doi.org/10.1021/jm001113w

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Differences in the actions of some blockers of the calcium-activated potassium permeability in mammalian red cells

Autor: M A R Shiner, David C. H. Benton, Craig J. Roxburgh, D. H. Jenkinson, Charon Robin Ganellin

Publikováno v: British Journal of Pharmacology. 126:169-178

1. The actions of some inhibitors of the Ca2+-activated K+ permeability in mammalian red cells have been compared. 2. Block of the permeability was assessed from the reduction in the net loss of K+ that followed the application of the Ca2+ ionophore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76123085223b4752a7dc015674e0465d
https://doi.org/10.1038/sj.bjp.0702292

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