Zobrazeno 1 - 10
of 15
pro vyhledávání: '"M A Parkhurst"'
Publikováno v:
Journal of Leukocyte Biology. 65:356-363
Mac-1 (CD11b/CD18) is known to be involved in neutrophil (PMN) adhesion to endothelial cells and extracellular matrix. Although antibodies to CD18 are being tested for therapy in humans, their role in PMN migration through the extracellular matrix is
Publikováno v:
The Journal of Immunology. 157:2539-2548
Recognition of the melanoma Ag gp100 by tumor-infiltrating lymphocytes (TIL) in vitro has been correlated with tumor regression in patients with metastatic melanoma treated with the adoptive transfer of TIL plus IL-2. Three common gp100 epitopes have
Autor:
W M Saltzman, M R Parkhurst
Publikováno v:
Cellular Immunology. 156:77-94
The migration of leukocytes through mucus must be an essential factor in the mucosal immune response, particularly during mucosal invasion by pathogens. We used two methods to evaluate the ability of neutrophils to migrate through human midcycle cerv
Publikováno v:
Developments in biologicals. 116
Immunotherapy with fusion of dendritic cells (DCs) and tumour cells potentially confers the advantages of DC antigen-presenting functionality and a continuous source of unaltered tumour antigens. However, fusion using chemical or viral fusogens has b
Publikováno v:
Journal of immunotherapy (Hagerstown, Md. : 1997). 24(3)
Tyrosinase has many advantages as a target antigen for the immunotherapy of patients with melanoma because it is expressed in nearly all melanoma specimens with a high degree of cellular homogeneity, and its distribution in normal tissues is limited
Autor:
M I, Nishimura, D, Avichezer, M C, Custer, C S, Lee, C, Chen, M R, Parkhurst, R A, Diamond, P F, Robbins, D J, Schwartzentruber, S A, Rosenberg
Publikováno v:
Cancer research. 59(24)
It is generally considered that MHC class I-restricted antigens are recognized by CD8+ T cells, whereas MHC class II-restricted antigens are recognized by CD4+ T cells. In the present study, we report an MHC class I-restricted CD4+ T cell isolated fr
Autor:
K R, Irvine, M R, Parkhurst, E P, Shulman, J P, Tupesis, M, Custer, C E, Touloukian, P F, Robbins, A G, Yafal, P, Greenhalgh, R P, Sutmuller, R, Offringa, S A, Rosenberg, N P, Restifo
Publikováno v:
Cancer research. 59(11)
To study the induction of anti-"self" CD8+ T-cell reactivity against the tumor antigen gp100, we used a mouse transgenic for a chimeric HLA-A*0201/H-2 Kb molecule (A2/Kb). We immunized the mice with a recombinant vaccinia virus encoding a form of gp1
Autor:
Y, Kawakami, P F, Robbins, X, Wang, J P, Tupesis, M R, Parkhurst, X, Kang, K, Sakaguchi, E, Appella, S A, Rosenberg
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(12)
To isolate melanoma Ags recognized by T cells, cDNA libraries made from melanoma cell lines were screened with four CTLs derived from tumor infiltrating lymphocytes (TIL) that were able to recognize melanoma cells in a HLA-A1, -A2, or -A3 restricted
Publikováno v:
Cancer research. 58(21)
Tyrosinase-related protein 2 (TRP2) is a melanosomal enzyme expressed in most mammalian melanocytes and melanomas. This protein has been identified as a melanoma antigen recognized by tumor reactive CTLs derived from tumor infiltrating lymphocytes in
Publikováno v:
Journal of exposure analysis and environmental epidemiology. 6(4)
In an epidemiologic study investigating influences of life-style and environment on lung cancer risk, CR-39 alpha-particle detectors, identified here as surface monitors, were affixed to subjects' selected household glass, ceramic, or enameled object