Zobrazeno 1 - 10
of 283
pro vyhledávání: '"M A Kenney"'
Autor:
Rodrigo Donato Costa, Farid José Thomaz Neto, M. Tarek Moustafa, Shari R. Atilano, Marilyn Chwa, Javier Cáceres-del-Carpi, Mohamed Hamid Mohamed, M. Cristina Kenney, Baruch D. Kuppermann
Publikováno v:
International Journal of Retina and Vitreous, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Purpose The present study tests the hypothesis that mitochondrial genes have retrograde signaling capacity that influences the expression of nuclear genes related to angiogenesis pathways. Cytoplasmic hybrid (cybrid) in vitro cell lines with
Externí odkaz:
https://doaj.org/article/45036aa2efb947bea20f5bdab0f2bd3c
Publikováno v:
Geoscience Communication, Vol 6, Pp 27-38 (2023)
Across the Midwest region of the United States, agriculturalists make decisions on a variety of timescales, ranging from daily to weekly, monthly, and seasonally. Ever-improving forecasts and decision support tools could assist the decision-making pr
Externí odkaz:
https://doaj.org/article/e2e4249277024764830af1fd9c0d96c2
Autor:
Andrew H. Dolinko, Marilyn Chwa, Kevin Schneider, Mithalesh K. Singh, Shari Atilano, Jie Wu, M. Cristina Kenney
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Diabetic retinopathy (DR) is the most common diabetic microvascular complication and cause of blindness in adults under the age of 65. Our results suggest that, when comparing transcriptomes of cultures grown in hypoxic conditions versus roo
Externí odkaz:
https://doaj.org/article/685d2d01f82643eb895625f5bfce2512
Autor:
Kayla M. White, Itamar Livnat, Caroline R. Frambach, John Doan, Urmi V. Mehta, Clara Yuh, Anton M. Palma, Kimberly A. Jameson, M. Cristina Kenney, Mitul C. Mehta, Chantal J. Boisvert, Wade R. Crow, Andrew W. Browne
Publikováno v:
International Journal of Retina and Vitreous, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Background Cone contrast threshold testing (CCT) provides quantitative measurements of color and contrast function to reveal changes in vision quality that are not standard endpoints in clinical trials. We utilize CCT to measure visual funct
Externí odkaz:
https://doaj.org/article/236640ec690d443ebce87df140fb7f09
Autor:
Kevin Schneider, Marilyn Chwa, Shari R. Atilano, Sonali Nashine, Nitin Udar, David S. Boyer, S. Michal Jazwinski, Michael V. Miceli, Anthony B. Nesburn, Baruch D. Kuppermann, M. Cristina Kenney
Publikováno v:
FASEB BioAdvances, Vol 4, Iss 10, Pp 675-689 (2022)
Abstract Activation of the Simulator of Interferon Genes (STING) system by mitochondrial (mt) DNA can upregulate type 1 interferon genes and enhance immune responses to combat bacterial and viral infections. In cancers, the tumor‐derived DNA activa
Externí odkaz:
https://doaj.org/article/09bf357e9bfd42d796eda35f47c0bc9b
Autor:
Nasim Salimiaghdam, Lata Singh, Mithalesh Kumar Singh, Marilyn Chwa, Shari Atilano, Zahra Mohtashami, Anthony Nesburn, Baruch D. Kuppermann, M. Cristina Kenney
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1326 (2023)
The aim of this study is to investigate the therapeutic potential of higher doses of PU-91, quercetin, or in combination on transmitochondrial cybrid cell lines with various mtDNA haplogroups derived from patients with age-related macular degeneratio
Externí odkaz:
https://doaj.org/article/2a0bd16b238b4a2282d42c2f31c00c2a
Autor:
Aneesh Neekhra, Julia Tran, Parsa R. Esfahani, Kevin Schneider, Khoa Pham, Ashish Sharma, Marilyn Chwa, Saurabh Luthra, Ana L. Gramajo, Saffar Mansoor, Baruch D. Kuppermann, M. Cristina Kenney
Publikováno v:
Journal of Ophthalmic & Vision Research, Vol 15, Pp 470-480 (2020)
Purpose: 7-ketocholesterol (7kCh), a natural byproduct of oxidation in lipoprotein deposits is implicated in the pathogenesis of diabetic retinopathy and age-related macular degeneration (AMD). This study was performed to investigate whether several
Externí odkaz:
https://doaj.org/article/295d056fd3cc4cc0855f0b3f4cee8e80
Autor:
Zahra Mohtashami, Mithalesh Kumar Singh, Farid Thomaz Neto, Nasim Salimiaghdam, Hossein Hasanpour, M. Cristina Kenney
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 518 (2023)
Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) is the most unearthed peptide encoded by mitochondrial DNA (mtDNA). It is an important regulator of the nuclear genome during times of stress because it promotes an adaptive stress resp
Externí odkaz:
https://doaj.org/article/c4b4ac9fb261441bbd4b8979fe494946
Autor:
Shari R. Atilano, Sina Abedi, Narcisa V. Ianopol, Mithalesh K. Singh, J Lucas Norman, Deepika Malik, Payam Falatoonzadeh, Marilyn Chwa, Anthony B. Nesburn, Baruch D. Kuppermann, M. Cristina Kenney
Publikováno v:
Cells, Vol 11, Iss 17, p 2655 (2022)
Mitochondrial (mt) DNA can be classified into haplogroups, which represent populations with different geographic origins. Individuals of maternal African backgrounds (L haplogroup) are more prone to develop specific diseases compared those with mater
Externí odkaz:
https://doaj.org/article/6a9ff33f61e44626ae55f0c5cdf9fcde
Autor:
Nasim Salimiaghdam, Lata Singh, Mithalesh K. Singh, Marilyn Chwa, Shari R. Atilano, Zahra Mohtashami, Anthony B. Nesburn, Baruch D. Kuppermann, Stephanie Y. Lu, M. Cristina Kenney
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 675 (2022)
We assessed the potential negative effects of bacteriostatic and bactericidal antibiotics on the AMD cybrid cell lines (K, U and J haplogroups). AMD cybrid cells were created and cultured in 96-well plates and treated with tetracycline (TETRA) and ci
Externí odkaz:
https://doaj.org/article/a23239b1136c4a09a66c438dc36b7bd3