Zobrazeno 1 - 10
of 67
pro vyhledávání: '"M A Kari"'
Autor:
Anissa A. Widjaja, Sivakumar Viswanathan, Shamini G. Shekeran, Eleonora Adami, Wei-Wen Lim, Sonia Chothani, Jessie Tan, Joyce Wei Ting Goh, Hui Mei Chen, Sze Yun Lim, Carine M. Boustany-Kari, Julie Hawkins, Enrico Petretto, Norbert Hübner, Sebastian Schafer, Thomas M. Coffman, Stuart A. Cook
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Repair processes in kidney are impaired in severe disease. Here, the authors show that in kidney failure, genetic or pharmacologic inhibition of IL11 releases the brake on regeneration, reverses tissue damage and restores kidney function.
Externí odkaz:
https://doaj.org/article/60e0f4d907fc4280bc1f88c1b900af64
Autor:
Glenn A. Reinhart, Paul C. Harrison, Kathleen Lincoln, Hongxing Chen, Peng Sun, Jon Hill, Hu Sheng Qian, Mark C. McHugh, Holly Clifford, Khing Jow Ng, Hong Wang, Danielle Fowler, Kristina Gueneva-Boucheva, Jehrod B. Brenneman, Todd Bosanac, Diane Wong, Ryan M. Fryer, Chris Sarko, Carine M. Boustany-Kari, Steven S. Pullen
Publikováno v:
The Journal of pharmacology and experimental therapeutics.
Activation of soluble guanylate cyclase (sGC) to restore cyclic guanosine monophosphate (cGMP) and improve functionality of nitric oxide (NO) pathways impaired by oxidative stress is a potential treatment for diabetic and chronic kidney disease. We r
Autor:
Amin Abedini, Ziyuan Ma, Julia Frederick, Poonam Dhillon, Michael S. Balzer, Rojesh Shrestha, Hongbo Liu, Steven Vitale, Kishor Devalaraja-Narashimha, Paola Grandi, Tanmoy Bhattacharyya, Erding Hu, Steven S. Pullen, Carine M Boustany-Kari, Paolo Guarnieri, Anil Karihaloo, Hanying Yan, Kyle Coleman, Matthew Palmer, Lea Sarov-Blat, Lori Morton, Christopher A. Hunter, Mingyao Li, Katalin Susztak
Kidneys have one of the most complex three-dimensional cellular organizations in the body, but the spatial molecular principles of kidney health and disease are poorly understood. Here we generate high-quality single cell (sc), single nuclear (sn), s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ef1d19933dc237011cb55146afd17db
https://doi.org/10.1101/2022.10.24.513598
https://doi.org/10.1101/2022.10.24.513598
Autor:
Amin, Abedini, Yuan O, Zhu, Shatakshee, Chatterjee, Gabor, Halasz, Kishor, Devalaraja-Narashimha, Rojesh, Shrestha, Michael S, Balzer, Jihwan, Park, Tong, Zhou, Ziyuan, Ma, Katie Marie, Sullivan, Hailong, Hu, Xin, Sheng, Hongbo, Liu, Yi, Wei, Carine M, Boustany-Kari, Uptal, Patel, Salem, Almaani, Matthew, Palmer, Raymond, Townsend, Shira, Blady, Jonathan, Hogan, Lori, Morton, Katalin, Susztak, Yan, Zhong
Publikováno v:
J Am Soc Nephrol
Background Microscopic analysis of urine sediment is probably the most commonly used diagnostic procedure in nephrology. The urinary cells, however, have not yet undergone careful unbiased characterization. Methods Single-cell transcriptomic analysis
Autor:
Junnan Wu, Matthew J. Seasock, Pazit Beckerman, Jeffrey B. Kopp, Andreas Linkermann, Joseph Wahba, Xin Sheng, Jay J. Kuo, Katalin Susztak, Archana Raman, Steven S. Pullen, Carine M. Boustany-Kari, Nathan J Coffey, Ziyuan Ma, Matthew Palmer, Dorottya Laczkó
Publikováno v:
J Clin Invest
Coding variants in apolipoprotein L1 (APOL1), termed G1 and G2, can explain most excess kidney disease risk in African Americans; however, the molecular pathways of APOL1-induced kidney dysfunction remain poorly understood. Here, we report that expre
Autor:
Laajanen, Merja, Saloniemi, Anne, Soppela, Jussi, V��is��nen, Anne-Mari, M��kitalo, Kari, Nivala, Vesa, Repola, Jaakko, Rostad, Ola, Nordgaard, St��le, Hvidsten Gabrielsen, Ingrid, Hellerstr��m, Gunnar, Stensl��kken, Joar
The ROSEWOOD4.0 project has developed differentroadmaps addressing stakeholders throughout Europe for facilitating the transfer of knowledge and collaboration between partnership regions. The main objective of the roadmaps on Hub level is to strength
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8696b7d4b54790dc6ba1aafda5cef9fe
Autor:
Jon Hill, Kathleen E. Corey, Dagmar Knebel, Raymond T. Chung, Lorena Pantano, Eric Simon, Shannan J. Ho Sui, George Agyapong, Zhu Zhuo, Julia F Doerner, Carine M. Boustany-Kari, Francesc Fernandez-Albert, Yang Shen, Jörg F. Rippmann, Werner Rust
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide. In adults with NAFLD, fibrosis can develop and progress to liver cirrhosis and liver failure. However, the underlying molecular mechanisms of fibrosis prog
Autor:
Behzad Najafian, Helen C. Looker, Robert G. Nelson, Cordell A. Esplin, Paolo Guarnieri, Jennifer L. Harder, Michael Mauer, Jon Hill, Carine M. Boustany-Kari, Matthias Kretzler, Pierre Jean Saulnier, Viji Nair
Publikováno v:
J Am Soc Nephrol
Background In type 1 diabetes, changes in the GFR and urine albumin-to-creatinine ratio (ACR) are related to changes in kidney structure that reflect disease progression. However, such changes have not been studied in type 2 diabetes. Methods Partici
Autor:
Liina Süvari, Markus Leskinen, P Anniina Palojärvi, M Anneli Kari, A Cecilia Janér, L Ursula Turpeinen, Otto Helve, Sture Andersson
Publikováno v:
Pediatric Research
BACKGROUND Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome (RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was to assess whether airway gene expression of mediators of pulmonary epithelial so
Autor:
YoSon Park, Christopher D. Brown, Matthew Palmer, Steven S. Pullen, Matthew J. Seasock, Paolo Guarnieri, Wen-Chao Song, Chengxiang Qiu, Shizheng Huang, Carine M. Boustany-Kari, Katalin Susztak, Yi-An Ko, Julie Hawkins, Xiang Xi Xu, Jon Hill, Jihwan Park, Joshua S. Bryer
Publikováno v:
Nature medicine
Chronic kidney disease (CKD), a condition in which the kidneys are unable to clear waste products, affects 700 million people globally. Genome-wide association studies (GWASs) have identified sequence variants for CKD; however, the biological basis o