Zobrazeno 1 - 10
of 576
pro vyhledávání: '"M A Cheever"'
Publikováno v:
Leukemia. 17:1301-1312
Among clinicians, initial awareness of the Wilms' tumor gene was limited mostly to pediatric oncologists. Almost a decade ago, overexpression of Wilms' tumor 1 (WT1) was observed in adult acute leukemia. Subsequent studies indicated that WT1 overexpr
Publikováno v:
The Journal of Immunology. 159:472-480
The long term goal of this study is to develop autoimmune prostatitis as a therapy for prostate cancer. An immune attack capable of destroying normal prostate epithelial cells should also destroy malignant prostate tissue and provide therapeutic bene
Autor:
M L, Disis, H, Bernhard, F M, Shiota, S L, Hand, J R, Gralow, E S, Huseby, S, Gillis, M A, Cheever
Publikováno v:
Blood. 88:202-210
The current studies evaluate granulocyte-macrophage colony-stimulating factor (GM-CSF) as a vaccine adjuvant. An important issue for developing vaccine therapy for human malignancy is identifying adjuvants that can elicit T-cell responses to proteins
Publikováno v:
The Journal of Immunology. 156:3151-3158
HER-2/neu, an overexpressed oncogenic protein, has been proposed as a human cancer vaccine target. HER-2/neu is a "self" protein, however, and methods of vaccine strategies that would be effective in immunizing patients to a "self" tumor Ag have not
Publikováno v:
The Journal of Immunology. 153:3630-3638
The aim of our study was to examine the potential usefulness of transducing the protein kinase C-gamma (PKC-gamma) cDNA gene into tumor-specific T cells as a technique for facilitating the generation of large numbers of functional Ag-specific T for t
Autor:
W Chen, M A Cheever
Publikováno v:
The Journal of Immunology. 152:4767-4774
To examine whether donor T cells can grow and survive long term in hosts without previous immunosuppression, cultured T cells (B6/Thy 1.1) specific to FBL-3 tumor were adoptively transferred into normal B6/Thy 1.2 mice and induced to proliferate in v
Publikováno v:
The Journal of Immunology. 146:4414-4420
The therapeutic efficacy of adoptive immunotherapy of cancer has been shown to positively correlate with the dose of tumor-immune T cells transferred. Therefore, the success of this therapy is critically dependent on the ability to procure large numb
Publikováno v:
The Journal of Immunology. 146:2059-2065
Activated ras proto-oncogenes contribute to the pathogenesis of many animal and human malignancies. ras proto-oncogenes are generally activated by point mutations within codons 12 or 61, which result in the expression of ras protein (p21) bearing cha
Publikováno v:
The Journal of Immunology. 144:3659-3666
The aim of the current study was to determine whether cultured tumor Ag-specific T cells could be induced to grow and maintained functional in large numbers in vivo by intermittent restimulation in vivo with specific Ag plus IL-2. T cells derived fro
Autor:
A, Gaiger, L, Carter, H, Greinix, D, Carter, P D, McNeill, R L, Houghton, C D, Cornellison, T S, Vedvick, Y A, Skeiky, M A, Cheever
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7
WT1 is an oncogenic protein expressed by the Wilms' tumor gene and overexpressed in the majority of acute myelogenous leukemias (AMLs) and chronic myelogenous leukemias (CMLs). The current study analyzed the sera of patients with AML and CML for the