Zobrazeno 1 - 7
of 7
pro vyhledávání: '"M A Casolaro"'
Publikováno v:
American Review of Respiratory Disease. 137:406-411
Langerhans' cells are a defined subpopulation of the mononuclear phagocyte system known to accumulate in the lung in histiocytosis X, an interstitial lung disorder strongly linked to cigarette smoking. To evaluate the hypothesis that cigarette smokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850c79dd69987d3037482a6f8f5babe5
https://doi.org/10.1164/ajrccm/137.2.406
https://doi.org/10.1164/ajrccm/137.2.406
Publikováno v:
Proceedings of the National Academy of Sciences. 86:680-684
To evaluate the possibility of administering therapeutic proteins via the respiratory route, we administered an aerosol of recombinant DNA-produced human alpha 1-antitrypsin (rAAT) to anesthetized sheep and measured levels of the protein in epithelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4417bd5a292752e372128f3ca2e447
https://doi.org/10.1073/pnas.86.2.680
https://doi.org/10.1073/pnas.86.2.680
Autor:
F Ogushi, David T. Curiel, R C Hubbard, Mark L. Brantly, G A Fells, M A Casolaro, Ronald G. Crystal
Publikováno v:
American Review of Respiratory Disease. 137:364-370
S-type alpha 1-antitrypsin (alpha 1AT) is a deficiency haplotype that differs from the common normal M1 (val213) alpha 1AT haplotype by a single amino acid (glu264 to val264). To evaluate the adequacy of the antineutrophil elastase protection associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6ccffbaef593360122d1ba2c3783d5
https://doi.org/10.1164/ajrccm/137.2.364
https://doi.org/10.1164/ajrccm/137.2.364
Autor:
J T Wittes, S E Sellers, Mark D. Wewers, K M McPhaul, Ronald G. Crystal, M A Casolaro, S C Swayze
Publikováno v:
New England Journal of Medicine. 316:1055-1062
In patients with alpha 1-antitrypsin deficiency, the development of emphysema is believed to be caused by the unchecked action of proteases on lung tissue. We evaluated the feasibility, safety, and biochemical efficacy of intermittent infusions of al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4494d0f6c7ba2762bffd651a46ef8fe3
https://doi.org/10.1056/nejm198704233161704
https://doi.org/10.1056/nejm198704233161704
Publikováno v:
The American review of respiratory disease. 135(2)
Tamoxifen, an agent that binds to intracytoplasmic estrogen receptors, was evaluated as a possible means of increasing alpha-1-antitrypsin (alpha 1AT) synthesis and/or secretion and thus alpha 1AT serum levels in subjects with the homozygous form of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a26bceac355b57dd380317995911f5a6
https://pubmed.ncbi.nlm.nih.gov/3492949
https://pubmed.ncbi.nlm.nih.gov/3492949
Autor:
M. A. Casolaro, G. Fells, M. Wewers, J. E. Pierce, F. Ogushi, R. Hubbard, S. Sellers, J. Forstrom, D. Lyons, G. Kawasaki, al. et
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 63(5)
To evaluate the potential use of recombinant DNA-produced alpha-1-antitrypsin (alpha-1-AT) to augment the lung antineutrophil elastase defenses in alpha-1-AT deficiency, we compared the kinetics of intravenously administered recombinant produced alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcab47b0f1e09382fb5ab9d697d2fe8
https://pubmed.ncbi.nlm.nih.gov/3500941
https://pubmed.ncbi.nlm.nih.gov/3500941
Publikováno v:
The American review of respiratory disease. 135(3)
The null-null phenotype of alpha 1-antitrypsin (alpha 1AT), a phenotype characterized by no detectable alpha 1AT in serum, presents a rare opportunity to examine the contribution of alpha 1AT to the antineutrophil elastase protection of the lower res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77c8af57d199bea578b4e74a53aee014
https://pubmed.ncbi.nlm.nih.gov/3493719
https://pubmed.ncbi.nlm.nih.gov/3493719