Zobrazeno 1 - 10
of 231
pro vyhledávání: '"M A Arnaout"'
Autor:
Brian D. Adair, Conroy O. Field, José L. Alonso, Jian-Ping Xiong, Shi-Xian Deng, Hyun Sook Ahn, Eivgeni Mashin, Clary B. Clish, Johannes van Agthoven, Mark Yeager, Youzhong Guo, David A. Tess, Donald W. Landry, Mortimer Poncz, M. Amin Arnaout
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Venous thrombosis (VT) is a common vascular disease associated with reduced survival and a high recurrence rate. VT is initiated by the accumulation of platelets and neutrophils at sites of endothelial cell activation. A role for platelet α
Externí odkaz:
https://doaj.org/article/5cb4e38292ca4761ba710d35e201c213
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-7 (2023)
Abstract Platelet integrin αIIbβ3 is maintained in a bent inactive state (low affinity to physiologic ligand), but can rapidly switch to a ligand-competent (high-affinity) state in response to intracellular signals (“inside-out” activation). On
Externí odkaz:
https://doaj.org/article/b492d27f5ecf4a52879de123c3081790
Autor:
Brian D. Adair, José L. Alonso, Johannes van Agthoven, Vincent Hayes, Hyun Sook Ahn, I-Shing Yu, Shu-Wha Lin, Jian-Ping Xiong, Mortimer Poncz, M. Amin Arnaout
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Current inhibitors of platelet integrin αIIbβ3 cause excessive bleeding, which limited their clinical use in cardiac patients. Here the authors design pure orthosteric αIIbβ3 inhibitors that prevent platelet aggregation and thrombosis without cau
Externí odkaz:
https://doaj.org/article/42565adb3ba2424890108c840e099336
Autor:
Abbas Dehnadi, A. Benedict Cosimi, Rex Neal Smith, Xiangen Li, José L. Alonso, Terry K. Means, M. Amin Arnaout
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Acute kidney injury can progress to chronic kidney disease. Here Dehnadiet al. develop a post-ischaemic chronic kidney disease model in cynomolgus monkeys and show that prophylactic inhibition of CD11b/CD18 leukocyte receptor via a monoclonal antibod
Externí odkaz:
https://doaj.org/article/d0055b59431d4c87ad00b0f269919925
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0184330 (2017)
In the kidney, the renal proximal tubule (PT) reabsorbs solutes into the peritubular capillaries through active transport. Here, we replicate this reabsorptive function in vitro by engineering a microfluidic PT. The microfluidic PT architecture compr
Externí odkaz:
https://doaj.org/article/5fa793bc386b43abbfa05872bea83fb6
Autor:
M. Amin Arnaout
Publikováno v:
F1000Research, Vol 5 (2016)
Integrins comprise a large family of αβ heterodimeric cell adhesion receptors that are expressed on all cells except red blood cells and that play essential roles in the regulation of cell growth and function. The leukocyte integrins, which include
Externí odkaz:
https://doaj.org/article/c32882e1954c477592fd11b8a7795039
Publikováno v:
Journal of Environmental and Public Health
Journal of Environmental and Public Health, Vol 2020 (2020)
Journal of Environmental and Public Health, Vol 2020 (2020)
Exposure to high concentrations of radon gas is the leading cause of lung cancer for nonsmokers according to the World Health Organization (WHO) figures. With poor ventilation standards and lack of awareness among Jordanians, constant monitoring of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0d85dd867dbe5cec3779e777e41878
https://doi.org/10.1155/2020/6668488
https://doi.org/10.1155/2020/6668488
Autor:
M. Amin Arnaout, I-Shing Yu, Shu-Wha Lin, Vincent Hayes, Johannes van Agthoven, Brian D. Adair, Hyun Sook Ahn, Mortimer Poncz, José Luis Alonso, Jian-Ping Xiong
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
A prevailing dogma is that inhibition of vascular thrombosis by antagonizing platelet integrin αIIbβ3 cannot be achieved without compromising hemostasis, thus causing serious bleeding and increased morbidity and mortality. It is speculated that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73459ec46bf2ca96677aa4912ef38249
http://link.springer.com/article/10.1038/s41467-019-13928-2
http://link.springer.com/article/10.1038/s41467-019-13928-2
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129561 (2015)
Acute kidney injury, often caused by an ischemic insult, is associated with significant short-term morbidity and mortality, and increased risk of chronic kidney disease. The factors affecting the renal response to injury following ischemia and reperf
Externí odkaz:
https://doaj.org/article/3eebf1f400c4489dbb9d78066fcb2bc1
Autor:
Zhongji Liao, Ke Zhu, Vasil Peev, Salim S. Hayek, Michael L. Merchant, Shuangxin Liu, Beata Samelko, Nicholas J. Tardi, Jochen Reiser, Stefan Hägele, Jon B. Klein, Brian D. Adair, Jianchao Ma, Sanford J. Shattil, M. Amin Arnaout, Jian Cai, Salvatore DiBartolo, Sanja Sever, Ranadheer R. Dande, Kwi Hye Koh, David Cimbaluk, Jing Li, Melissa Tracy, Changli Wei
Publikováno v:
J Clin Invest
Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived circulating signaling molecule that has been implicated in chronic kidney disease, such as focal segmental glomerulosclerosis (FSGS). Typically, native uPAR (isoform 1) tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699b545d832fda89d50d898ad6c77e57
https://doi.org/10.1172/jci124793
https://doi.org/10.1172/jci124793