Zobrazeno 1 - 10
of 37
pro vyhledávání: '"M A, Venkatachalam"'
Publikováno v:
The Biochemical journal. 360(Pt 1)
Caspase-9 is the apex caspase of the mitochondrial pathway of apoptosis, which plays a critical role in apoptotic initiation and progression. However, gene regulation of caspase-9 is largely unknown. This is in part due to the lack of information on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e5309ff82ec168f49d43b3d92cf837a
https://pubmed.ncbi.nlm.nih.gov/11695991
https://pubmed.ncbi.nlm.nih.gov/11695991
Autor:
Z, Dong, M A, Venkatachalam, J, Wang, Y, Patel, P, Saikumar, G L, Semenza, T, Force, J, Nishiyama
Publikováno v:
The Journal of biological chemistry. 276(22)
Hypoxia is a key determinant of tissue pathology during tumor development and organ ischemia. However, little is known regarding hypoxic regulation of genes that are directly involved in cell death or death resistance. Here we report the striking ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4791aff1a6a4aacec2180491d4fa489b
https://pubmed.ncbi.nlm.nih.gov/11278985
https://pubmed.ncbi.nlm.nih.gov/11278985
Publikováno v:
The American journal of pathology. 156(5)
Heme oxygenase (HO) is the rate limiting enzyme in the degradation of heme, and its isozyme, HO-1, may protect against tissue injury. One posited mechanism is the degradation of heme released from destabilized heme proteins. We demonstrate that HO-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1bd8993aa7ff76cd4e929aaa433c2b8f
https://pubmed.ncbi.nlm.nih.gov/10793064
https://pubmed.ncbi.nlm.nih.gov/10793064
Publikováno v:
The Biochemical journal.
We have shown that reoxygenation of hypoxic rat kidney proximaltubule cells leads to apoptosis. This is mediated by translocation ofBax from the cytosol to mitochondria, accompanied by release ofmitochondrial cytochrome c (cyt.c). The present studyha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7925d9126e20eff77b5c9f071954c281
https://pubmed.ncbi.nlm.nih.gov/10769169
https://pubmed.ncbi.nlm.nih.gov/10769169
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 78(6)
Studies during the past decade have led to the recognition of a fundamental, widely expressed mechanism of structural damage in energy-deprived cells, which is suppressed by physiologic levels of glycine and is independent of Ca2+ availability or alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d51e30b548d6e5a0d627e0aef1b84e6
https://pubmed.ncbi.nlm.nih.gov/9645756
https://pubmed.ncbi.nlm.nih.gov/9645756
Publikováno v:
The American journal of pathology. 151(5)
Autolytic DNA breakdown, detected as smears in electrophoretic gels, is a late event in necrosis. On the other hand, internucleosomal DNA cleavage, visualized as ladders, is thought to be a hallmark of apoptosis. We now report that this specific form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::365f87a7013cc37aa7e1976cc8c47805
https://pubmed.ncbi.nlm.nih.gov/9358745
https://pubmed.ncbi.nlm.nih.gov/9358745
Autor:
M A, Venkatachalam, J M, Weinberg
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 9
Increase of intracellular free Ca2+ (Caf) plays an important role in the deterioration of cell structure that occurs during depletion of adenosine triphosphate (ATP). On the other hand a form of Ca2+ independent cell injury due to glycine deficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47c18c371bfc259203c7f4f3624ca9d5
https://pubmed.ncbi.nlm.nih.gov/7800249
https://pubmed.ncbi.nlm.nih.gov/7800249
Autor:
J M, Weinberg, M A, Venkatachalam
Publikováno v:
Mineral and electrolyte metabolism. 18(2-5)
During the past several years studies using freshly isolated proximal tubules in suspension have contributed to understanding several of the major cellular processes underlying ischemic and related forms of acute renal failure. Tubules have a large c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31a795e5555a1064b0a883a86aca02ee
https://pubmed.ncbi.nlm.nih.gov/1465046
https://pubmed.ncbi.nlm.nih.gov/1465046
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 65(6)
Treatment of two cultured renal tubule epithelial cell lines, MDCK and LLC-PK1, with ionomycin produced rapidly evolving models of lethal cell injury characterized by increases of cytosolic free calcium to the microM level within 15 minutes followed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf25ab76540e71f8570a9bc0d8d91a5d
https://pubmed.ncbi.nlm.nih.gov/1753712
https://pubmed.ncbi.nlm.nih.gov/1753712
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 4(15)
Kidney proximal tubules are resistant to hypoxic injury if glycine or L-alanine is present in their incubation medium. Protection does not depend on the concentration or turnover of ATP in cells. We have investigated structure-function relationships
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6bebc8007341644b61c5c16615b9fb8
https://pubmed.ncbi.nlm.nih.gov/2253849
https://pubmed.ncbi.nlm.nih.gov/2253849