Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions

Autor: Timothy M. OʼShea, Alexander L. Wollenberg, Jae H. Kim, Yan Ao, Timothy J. Deming, Michael V. Sofroniew

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)

Implantable biomaterials evoke foreign body responses in the central nervous system. The authors compare hydrogel-based biomaterials to identify cellular interactions and molecular mechanisms that drive different types of foreign body responses that

Externí odkaz: https://doaj.org/article/3f9ac0fa07be4aa38f0b487bb917087c

Treatment of trauma related anger in operation enduring freedom, operation Iraqi freedom, and operation New Dawn veterans: Rationale and study protocol

Autor: M. Tracie Shea, Jennifer Lambert, Madhavi K. Reddy, Candice Presseau, Elizabeth Sevin, Robert L. Stout

Publikováno v: Contemporary Clinical Trials Communications, Vol 12, Iss , Pp 26-31 (2018)

Background: Problems with anger and aggression are highly prevalent in Veterans of multiple war eras, including the most recent conflicts in Afghanistan (Operation Enduring Freedom; OEF) and Iraq (Operation Iraqi Freedom; OIF). The consequences of th

Externí odkaz: https://doaj.org/article/623287ee3d9546b88c7a22744d569b66

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Autor: Xia Jiang, Paul F. O’Reilly, Hugues Aschard, Yi-Hsiang Hsu, J. Brent Richards, Josée Dupuis, Erik Ingelsson, David Karasik, Stefan Pilz, Diane Berry, Bryan Kestenbaum, Jusheng Zheng, Jianan Luan, Eleni Sofianopoulou, Elizabeth A. Streeten, Demetrius Albanes, Pamela L. Lutsey, Lu Yao, Weihong Tang, Michael J. Econs, Henri Wallaschofski, Henry Völzke, Ang Zhou, Chris Power, Mark I. McCarthy, Erin D. Michos, Eric Boerwinkle, Stephanie J. Weinstein, Neal D. Freedman, Wen-Yi Huang, Natasja M. Van Schoor, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Anke Enneman, L. Adrienne Cupples, Sarah L. Booth, Ramachandran S. Vasan, Ching-Ti Liu, Yanhua Zhou, Samuli Ripatti, Claes Ohlsson, Liesbeth Vandenput, Mattias Lorentzon, Johan G. Eriksson, M. Kyla Shea, Denise K. Houston, Stephen B. Kritchevsky, Yongmei Liu, Kurt K. Lohman, Luigi Ferrucci, Munro Peacock, Christian Gieger, Marian Beekman, Eline Slagboom, Joris Deelen, Diana van Heemst, Marcus E. Kleber, Winfried März, Ian H. de Boer, Alexis C. Wood, Jerome I. Rotter, Stephen S. Rich, Cassianne Robinson-Cohen, Martin den Heijer, Marjo-Riitta Jarvelin, Alana Cavadino, Peter K. Joshi, James F. Wilson, Caroline Hayward, Lars Lind, Karl Michaëlsson, Stella Trompet, M. Carola Zillikens, Andre G. Uitterlinden, Fernando Rivadeneira, Linda Broer, Lina Zgaga, Harry Campbell, Evropi Theodoratou, Susan M. Farrington, Maria Timofeeva, Malcolm G. Dunlop, Ana M. Valdes, Emmi Tikkanen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Mika Kähönen, Olli T. Raitakari, Vera Mikkilä, M. Arfan Ikram, Naveed Sattar, J. Wouter Jukema, Nicholas J. Wareham, Claudia Langenberg, Nita G. Forouhi, Thomas E. Gundersen, Kay-Tee Khaw, Adam S. Butterworth, John Danesh, Timothy Spector, Thomas J. Wang, Elina Hyppönen, Peter Kraft, Douglas P. Kiel

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Vitamin D deficiency is associated with multiple human pathologic conditions. In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evi

Externí odkaz: https://doaj.org/article/45ceebb3cb0e4473b2cfdeb800d4099c

Borderline personality disorder symptom networks across adolescent and adult clinical samples: examining symptom centrality and replicability

Autor: Jessica R. Peters, Michael L. Crowe, Theresa Morgan, Mark Zimmerman, Carla Sharp, Carlos M. Grilo, Charles A. Sanislow, M. Tracie Shea, Mary C. Zanarini, Thomas H. McGlashan, Leslie C. Morey, Andrew E. Skodol, Shirley Yen

Publikováno v: Psychological medicine.

Background Numerous theories posit different core features to borderline personality disorder (BPD). Recent advances in network analysis provide a method of examining the relative centrality of BPD symptoms, as well as examine the replicability of fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033d877a8e9eb8e2326e86fb7b0fe5af
https://pubmed.ncbi.nlm.nih.gov/35094733

Brain vitamin D forms, cognitive decline, and neuropathology in community‐dwelling older adults

Autor: M Kyla, Shea, Kathryn, Barger, Bess, Dawson-Hughes, Sue E, Leurgans, Xueyan, Fu, Bryan D, James, Thomas M, Holland, Puja, Agarwal, Jifan, Wang, Gregory, Matuszek, Nicholas E, Heger, Julie A, Schneider, Sarah L, Booth

Publikováno v: Alzheimer's & Dementia.

Vitamin D purportedly protects against cognitive decline and dementia based on observational data using circulating 25-hydroxyvitamin D (25(OH)D). Little is known about vitamin D in the human brain and the association with dementia or neuropathology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832b3192cb705abb4ffa4e5ef69f1f6f
https://doi.org/10.1002/alz.12836