Zobrazeno 1 - 10
of 14
pro vyhledávání: '"M A, Piatyszek"'
Autor:
K Hiyama, Y Hirai, S Kyoizumi, M Akiyama, E Hiyama, M A Piatyszek, J W Shay, S Ishioka, M Yamakido
Publikováno v:
The Journal of Immunology. 155:3711-3715
This is the first report describing up-regulation of telomerase activity in human normal cells. Telomerase, a ribonucleoprotein enzyme, has been thought to be involved in maintaining telomere length stability in germline and most cancer cells, but no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f32c18870404ebd1ac680624c9fdfae7
https://doi.org/10.4049/jimmunol.155.8.3711
https://doi.org/10.4049/jimmunol.155.8.3711
Autor:
K, Yashima, L A, Litzky, L, Kaiser, T, Rogers, S, Lam, I I, Wistuba, S, Milchgrub, S, Srivastava, M A, Piatyszek, J W, Shay, A F, Gazdar
Publikováno v:
Cancer research. 57(12)
To investigate the role of telomerase in the multistage pathogenesis of lung cancer, we examined 205 fresh and archival tissue samples obtained from 40 patients, 34 of whom had invasive lung carcinoma, 5 with carcinoma in situ (CIS) without invasion,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9aaf1d0a93d74e18a538c026f32df1b3
https://pubmed.ncbi.nlm.nih.gov/9192812
https://pubmed.ncbi.nlm.nih.gov/9192812
Autor:
T K, Pandita, E J, Hall, T K, Hei, M A, Piatyszek, W E, Wright, C Q, Piao, R K, Pandita, J C, Willey, C R, Geard, M B, Kastan, J W, Shay
Publikováno v:
Oncogene. 13(7)
Chromosome end-to-end associations seen at metaphase involve telomeres and are commonly observed in cells derived from individuals with ataxia telangiectasia and most types of human tumors. The associations may arise because of short telomeres and/or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a816f0101bd34a7c9d55e0fa2235abf5
https://pubmed.ncbi.nlm.nih.gov/8875980
https://pubmed.ncbi.nlm.nih.gov/8875980
Publikováno v:
Moleculargeneral genetics : MGG. 252(3)
Telomeres of most eucaryotes terminate in long stretches of short, guanine-rich repeats. Telomerase, a specialized enzyme with reverse transcriptase-like activity, has been shown to synthesize these repeats in many lower eucaryotes and several animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4f5cf5a12e2593cd8625a7576b76c7
https://pubmed.ncbi.nlm.nih.gov/8842154
https://pubmed.ncbi.nlm.nih.gov/8842154
Publikováno v:
Oncogene. 13(1)
Telomeres have a vital role in maintaining chromosome stability and are essential for long term viability. Since the very ends of linear chromosomes cannot replicate, telomeres shorten in normal somatic cells eventually resulting in growth inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23fc13d6d859eeded708fe554df7b41d
https://pubmed.ncbi.nlm.nih.gov/8700542
https://pubmed.ncbi.nlm.nih.gov/8700542
Autor:
W, Zhang, M A, Piatyszek, T, Kobayashi, E, Estey, M, Andreeff, A B, Deisseroth, W E, Wright, J W, Shay
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(5)
The terminal regions of human chromosomes, the telomeres, shorten with each cell division in most normal somatic cells. Telomerase, a ribonucleoprotein that synthesizes telomeric DNA onto chromosomal ends, is activated in germline cells and almost al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7a23e9e50e7b3a66736493914dd7c67
https://pubmed.ncbi.nlm.nih.gov/9816233
https://pubmed.ncbi.nlm.nih.gov/9816233
Publikováno v:
The EMBO journal. 15(7)
Hybrids between immortal cells that express telomerase and normal cells that lack telomerase have a limited lifespan. We demonstrate that telomerase is repressed in such hybrids. Treatment of immortal human cell lines with certain oligonucleotides re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45d2f191ef172b4fe370c8db28a9d743
https://pubmed.ncbi.nlm.nih.gov/8612598
https://pubmed.ncbi.nlm.nih.gov/8612598
Publikováno v:
Cancer research. 56(3)
Telomerase activity has been detected in many human immortal cells lines and in tumor tissues, whereas it is generally absent from primary cell strains and from many tumor adjacent tissue samples. With the recently cloned human telomerase RNA (hTR),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b08b87bb62db17e8bb99f78da1a31a5
https://pubmed.ncbi.nlm.nih.gov/8564985
https://pubmed.ncbi.nlm.nih.gov/8564985
Publikováno v:
Developmental genetics. 18(2)
Telomerase is a ribonucleoprotein that synthesizes telomere repeats onto chromosome ends and is involved in maintaining telomere length in germline tissues and in immortal and cancer cells. In the present study, the temporal regulation of expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::004ee53d087bb8b082eeb2cd9ad76862
https://pubmed.ncbi.nlm.nih.gov/8934879
https://pubmed.ncbi.nlm.nih.gov/8934879
Publikováno v:
Cancer research. 56(1)
We urgently need biochemical markers to detect the malignant nature and pathological states of the human prostate. We report that telomerase activity is associated with prostate cancer but absent in the benign disease and normal gland. Telomerase is,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7c26cd922535fa89d585f119c33303e
https://pubmed.ncbi.nlm.nih.gov/8548767
https://pubmed.ncbi.nlm.nih.gov/8548767