Zobrazeno 1 - 10
of 16
pro vyhledávání: '"M A, Pagel"'
Publikováno v:
Cancer research. 61(21)
Modulation of thiol levels may alter both the efficacy and toxicity of chemotherapeutic agents. We investigated cytoenhancement, using L-buthionine-[S,R]-sulfoximine (BSO) to reduce cellular glutathione levels prior to intracarotid alkylator administ
Autor:
L L, Muldoon, M A, Pagel, R A, Kroll, R E, Brummett, N D, Doolittle, E G, Zuhowski, M J, Egorin, E A, Neuwelt
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(1)
Platinum-based chemotherapeutic agents, such as carboplatin and cisplatin, are effective against many human tumors, but their use may be limited by a high incidence of ototoxicity. Delayed administration of the chemoprotective agent sodium thiosulfat
Publikováno v:
AJNR Am J Neuroradiol
BACKGROUND AND PURPOSE: Osmotic disruption of the blood-brain barrier (BBB) provides a method for transvascular delivery of therapeutic agents to the brain. The apparent global delivery of viral-sized iron oxide particles to the rat brain after BBB o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9146a626e2ef002629e585c75dbe049e
https://europepmc.org/articles/PMC7056106/
https://europepmc.org/articles/PMC7056106/
Autor:
E A, Neuwelt, R E, Brummett, N D, Doolittle, L L, Muldoon, R A, Kroll, M A, Pagel, R, Dojan, V, Church, L G, Remsen, J S, Bubalo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 286(1)
Sodium thiosulfate (STS) provides protection against carboplatin-induced ototoxicity in an animal model. The purpose of this study was to determine the STS dose required for otoprotection, in patients with malignant brain tumors treated with carbopla
Publikováno v:
Neurosurgery. 38(4)
The volume of distribution in tissue (Vt) that can be achieved by direct interstitial infusion of therapeutic agents into brain is limited. The maintenance of a pressure gradient during interstitial infusion to establish fluid convection has been sho
Autor:
E A, Neuwelt, R E, Brummett, L G, Remsen, R A, Kroll, M A, Pagel, C I, McCormick, S, Guitjens, L L, Muldoon
Publikováno v:
Cancer research. 56(4)
When carboplatin (cis-diammine-1,1-cyclobutane-dicarboxylato-platinum) delivery to brain tumors is optimized with osmotic blood-brain barrier disruption (BBBD), high frequency hearing loss can result. Treatment with sodium thiosulfate (STS) blocked c
Autor:
L L, Muldoon, G, Nilaver, R A, Kroll, M A, Pagel, X O, Breakefield, E A, Chiocca, B L, Davidson, R, Weissleder, E A, Neuwelt
Publikováno v:
The American journal of pathology. 147(6)
Delivery of adenovirus, herpes simplex virus (HSV), and paramagnetic monocrystalline iron oxide nanoparticles (MION) to rat brain (n = 64) was assessed after intracerebral inoculation or osmotic disruption of the blood-brain barrier (BBB). After intr
Publikováno v:
AJNR Am J Neuroradiol
PURPOSE: To establish changes on MR of the brain in a feline model of Sandhoff disease in order to develop standards by which this model may be used in future noninvasive studies. METHODS: Five affected felines and six age-matched, littermate control
Publikováno v:
Therapeutic immunology. 1(6)
The feasibility of utilizing the differential permeability of the blood-tumour barrier to low- vs. high-molecular-weight compounds is demonstrated in a brain tumour model. Nude rats (n = 27) with or without intracerebral tumours received intravenous
Publikováno v:
Anesthesiology. 89:780A