X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements

Autor: Markus Scholz, Katrin Horn, Janne Pott, Matthias Wuttke, Andreas Kühnapfel, M. Kamal Nasr, Holger Kirsten, Yong Li, Anselm Hoppmann, Mathias Gorski, Sahar Ghasemi, Man Li, Adrienne Tin, Jin-Fang Chai, Massimiliano Cocca, Judy Wang, Teresa Nutile, Masato Akiyama, Bjørn Olav Åsvold, Nisha Bansal, Mary L. Biggs, Thibaud Boutin, Hermann Brenner, Ben Brumpton, Ralph Burkhardt, Jianwen Cai, Archie Campbell, Harry Campbell, John Chalmers, Daniel I. Chasman, Miao Ling Chee, Miao Li Chee, Xu Chen, Ching-Yu Cheng, Renata Cifkova, Martha Daviglus, Graciela Delgado, Katalin Dittrich, Todd L. Edwards, Karlhans Endlich, J. Michael Gaziano, Ayush Giri, Franco Giulianini, Scott D. Gordon, Daniel F. Gudbjartsson, Stein Hallan, Pavel Hamet, Catharina A. Hartman, Caroline Hayward, Iris M. Heid, Jacklyn N. Hellwege, Bernd Holleczek, Hilma Holm, Nina Hutri-Kähönen, Kristian Hveem, Berend Isermann, Jost B. Jonas, Peter K. Joshi, Yoichiro Kamatani, Masahiro Kanai, Mika Kastarinen, Chiea Chuen Khor, Wieland Kiess, Marcus E. Kleber, Antje Körner, Peter Kovacs, Alena Krajcoviechova, Holly Kramer, Bernhard K. Krämer, Mikko Kuokkanen, Mika Kähönen, Leslie A. Lange, James P. Lash, Terho Lehtimäki, Hengtong Li, Bridget M. Lin, Jianjun Liu, Markus Loeffler, Leo-Pekka Lyytikäinen, Patrik K. E. Magnusson, Nicholas G. Martin, Koichi Matsuda, Yuri Milaneschi, Pashupati P. Mishra, Nina Mononen, Grant W. Montgomery, Dennis O. Mook-Kanamori, Josyf C. Mychaleckyj, Winfried März, Matthias Nauck, Kjell Nikus, Ilja M. Nolte, Raymond Noordam, Yukinori Okada, Isleifur Olafsson, Albertine J. Oldehinkel, Brenda W. J. H. Penninx, Markus Perola, Nicola Pirastu, Ozren Polasek, David J. Porteous, Tanja Poulain, Bruce M. Psaty, Ton J. Rabelink, Laura M. Raffield, Olli T. Raitakari, Humaira Rasheed, Dermot F. Reilly, Kenneth M. Rice, Anne Richmond, Paul M. Ridker, Jerome I. Rotter, Igor Rudan, Charumathi Sabanayagam, Veikko Salomaa, Neil Schneiderman, Ben Schöttker, Mario Sims, Harold Snieder, Klaus J. Stark, Kari Stefansson, Hannah Stocker, Michael Stumvoll, Patrick Sulem, Gardar Sveinbjornsson, Per O. Svensson, E-Shyong Tai, Kent D. Taylor, Bamidele O. Tayo, Andrej Teren, Yih-Chung Tham, Joachim Thiery, Chris H. L. Thio, Laurent F. Thomas, Johanne Tremblay, Anke Tönjes, Peter J. van der Most, Veronique Vitart, Uwe Völker, Ya Xing Wang, Chaolong Wang, Wen Bin Wei, John B. Whitfield, Sarah H. Wild, James F. Wilson, Thomas W. Winkler, Tien-Yin Wong, Mark Woodward, Xueling Sim, Audrey Y. Chu, Mary F. Feitosa, Unnur Thorsteinsdottir, Adriana M. Hung, Alexander Teumer, Nora Franceschini, Afshin Parsa, Anna Köttgen, Pascal Schlosser, Cristian Pattaro

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-relat

Externí odkaz: https://doaj.org/article/268d127148904565be810f5bb7b9bb96

Mendelian randomization indicates causal effects of estradiol levels on kidney function in males

Autor: M. Kamal Nasr, Claudia Schurmann, Erwin P. Böttinger, Alexander Teumer

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

ContextChronic kidney disease (CKD) is a public health burden worldwide. Epidemiological studies observed an association between sex hormones, including estradiol, and kidney function.ObjectiveWe conducted a Mendelian randomization (MR) study to asse

Externí odkaz: https://doaj.org/article/6f24cced5020468ba2c96dc25ba44b70

A Low-Cost Millimeter-Wave 5G V2X Multi-Beam Dual-Polarized Windshield Antenna

Autor: Abdelhamid M. H. Nasr, Kamal Sarabandi

Publikováno v: IEEE Open Journal of Antennas and Propagation, Vol 3, Pp 1313-1323 (2022)

Design procedure and experimental validation for a millimeter-wave (MMW) vehicular antenna with simultaneous multi-beam, for 5G V2X application, is presented. The design overcomes the constraint for requiring both wide angular coverage and high gain

Externí odkaz: https://doaj.org/article/f7bce493cfe54a73986935badad92875

Reduction Behavior and Characteristics of Metal Oxides in the Nanoscale

Autor: K. S. Abdel Halim, A. A. El-Geassy, Mohamed Ramadan, M. I. Nasr, A. Hussein, Naglaa Fathy, Abdulaziz S. Alghamdi

Publikováno v: Metals, Vol 12, Iss 12, p 2182 (2022)

The development of nanomaterials and nanotechnology enables the production of nanosized metallic alloys with advanced characteristics from their oxides via a thermal reduction technique. The aim of the present work was to produce metallic iron, nicke

Externí odkaz: https://doaj.org/article/9c5c082d6a8349f79eec563d5b96bc26

siRNA inhibition and not chemical inhibition of Suv39h1/2 enhances pre-implantation embryonic development of bovine somatic cell nuclear transfer embryos.

Autor: Farnoosh Jafarpour, Faezeh Ghazvini Zadegan, Somayyeh Ostadhosseini, Mehdi Hajian, Abbas Kiani-Esfahani, M H Nasr-Esfahani

Publikováno v: PLoS ONE, Vol 15, Iss 6, p e0233880 (2020)

The efficiency of somatic cell nuclear transfer (SCNT) is low due to the strong resistance of somatic donor cells to epigenetic reprogramming. Many epigenetic drugs targeting DNA methylation and histone acetylation have been used in attempts to impro

Externí odkaz: https://doaj.org/article/8ce9306169ba4bfb8368be780272f19c