Zobrazeno 1 - 10
of 93
pro vyhledávání: '"M A, Moscarello"'
Publikováno v:
Journal of Polymer Science: Polymer Symposia. 66:391-398
A static platelet adhesion test using whole human blood was employed to assess the affinity of various bare polymer (sulfonated polystyrene, acetal resin, Teflon FEP, polystyrene) surfaces as well as various surfaces of glass and polymers that were c
Publikováno v:
Journal of Neuroscience Research. 35:618-628
The myelin basic protein (MBPs) represent a family of proteins (charge isomers) which account for 35% of the total myelin protein. Localization studies have been inconclusive because MBP is not a single protein. Antibodies obtained by injection of MB
Autor:
T A Tompkins, M A Moscarello
Publikováno v:
Journal of Biological Chemistry. 266:4228-4236
A phosphatidylinositol-specific phospholipase C (PI-PLC) has been isolated from bovine brain (purification factor of 5.6 x 10(4)). By sodium dodecyl sulfate-polyacrylamide gel electrophoresis, it had a Mr of 57,000. Neither amino nor neutral sugars w
Publikováno v:
Journal of Neurochemistry. 55:1697-1702
Myelin basic protein (MBP) from shark (Chondricthyes) consists of a simpler mixture of charge isomers than human MBP. About two-thirds of the total amount applied to a CM-52 cellulose cation-exchange column was recovered in the unbound fraction of th
Publikováno v:
Molecularcellular proteomics : MCP. 2(7)
Myelin basic protein (MBP) represents a candidate autoantigen in multiple sclerosis (MS). We isolated MBP from normal and MS human white matter and purified six components (charge isomers) to compare the post-translational modifications on each. The
Publikováno v:
Journal of neurochemistry. 81(2)
In earlier studies we demonstrated that an increase in the relative amounts of citrullinated myelin basic protein (MBP) was found in multiple sclerosis (Moscarello et al. 1994). To determine the temporal relationship between the citrullinated MBP and
Publikováno v:
Journal of neuroscience research. 57(4)
Myelin basic protein (MBP) occurs as a number of charge isomers due to phosphorylation, deamidation, and deimination of arginine to citrulline. All of these modifications decrease the net positive charge of the protein and its ability to cause aggreg
Autor:
M. A. Moscarello, A. M. Fannon
Publikováno v:
Annals of the New York Academy of Sciences. 605:379-381
Publikováno v:
Journal of neuroscience research. 53(2)
Transgenic mice (ND4) containing 70 copies of the transgene encoding DM20 were clinically normal up to 3 months of age, spontaneously demyelinated there-after and died in 8-10 months. Whereas the myelin fraction from normal mice increased in amount f
Publikováno v:
European journal of cell biology. 74(2)
An astrocytoma cell line (HTB-14), expressing high amounts of a CD44 variant compared to other astrocytoma lines was shown to bind myelin basic protein to a greater extent than low expressing lines in a concentration-dependent manner. The CD44 varian