Zobrazeno 1 - 10
of 28
pro vyhledávání: '"M A, Medinsky"'
Publikováno v:
Toxicological Sciences. 19:124-132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdf5b88ab46615666c9c7a1abbcf85e0
https://doi.org/10.1093/toxsci/19.1.124
https://doi.org/10.1093/toxsci/19.1.124
Publikováno v:
Fundamental and Applied Toxicology. 16:330-336
We studied the deposition of ultrafine aerosols, ranging in geometric diameter from 0.005 to 0.1 microns, in the nasal airway of Fischer-344/N rats, at inspiratory flow rates of 200, 300, 400, and 600 ml/min. Simultaneously, we measured the pressure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b03b08137506f5cb69300e294cd04d4
https://doi.org/10.1016/0272-0590(91)90117-m
https://doi.org/10.1016/0272-0590(91)90117-m
Publikováno v:
Toxicological Sciences. 16:330-336
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50aa8216f0a422a0fdf1c72b98023ac3
https://doi.org/10.1093/toxsci/16.2.330
https://doi.org/10.1093/toxsci/16.2.330
Autor:
M. A. MEDINSKY, W. E. BECHTOLD, L. S. BlRNBAUM, J. A. BOND, D. G. BURT, Y. S. CHENG, N. A. GlLLETT, D. K. GULATI, C. H. HOBBS, J. A. PlCKRELL
Publikováno v:
Toxicological Sciences. 15:308-319
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba68b24be0641fcedbcb17dab8694f9c
https://doi.org/10.1093/toxsci/15.2.308
https://doi.org/10.1093/toxsci/15.2.308
Autor:
J L, Valentine, S S, Lee, M J, Seaton, B, Asgharian, G, Farris, J C, Corton, F J, Gonzalez, M A, Medinsky
Publikováno v:
Toxicology and applied pharmacology. 141(1)
Transgenic CYP2E1 knockout mice (cyp2e1-/-) were used to investigate the involvement of CYP2E1 in the in vivo metabolism of benzene and in the development of benzene-induced toxicity. After benzene exposure, absence of CYP2E1 protein was confirmed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7aa30d4fda26ba1ed645139bd0e563af
https://pubmed.ncbi.nlm.nih.gov/8917693
https://pubmed.ncbi.nlm.nih.gov/8917693
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 30(2)
Methyl tertiary-butyl ether (MTBE) and its metabolite tertiary-butanol (TBA) both cause renal tumors in chronically exposed male rats. Knowledge of the kinetic behavior of MTBE and TBA in rats and its comparison to the kinetics of these chemicals in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6ed98a21dd81f02ff3ef611a0f96f39
https://pubmed.ncbi.nlm.nih.gov/8812274
https://pubmed.ncbi.nlm.nih.gov/8812274
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 20(3)
Physiologically based pharmacokinetic models for volatile organic chemicals typically describe the respiratory tract as a single compartment in which chemicals in the alveolar air space and the arterial blood are in instantaneous equilibrium. These m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4d02a80c9c6ba818ddd53a48b4bf866
https://pubmed.ncbi.nlm.nih.gov/8504900
https://pubmed.ncbi.nlm.nih.gov/8504900
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 20(3)
The pig has been proposed as a potential animal model for methanol-induced neuro-ocular toxicosis in humans because of its low liver tetrahydrofolate levels and slower rate of formate metabolism compared to those of humans. To examine the validity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3789bc20fc098316739585e42d1cb2be
https://pubmed.ncbi.nlm.nih.gov/8504908
https://pubmed.ncbi.nlm.nih.gov/8504908
Publikováno v:
IARC scientific publications. (127)
1,3-Butadiene is carcinogenic to rats and mice, although mice are more sensitive than rats. It is not known if butadiene poses a carcinogenic risk to humans. Butadiene requires metabolic activation to reactive epoxides that can bind to DNA to initiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3cc2dbcf27f19371c8e0559278b15624
https://pubmed.ncbi.nlm.nih.gov/8070886
https://pubmed.ncbi.nlm.nih.gov/8070886
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 19(1)
The glycol ethers methoxyethanol (ME), ethoxyethanol (EE), and butoxyethanol (BE) are widely used in industrial and household products. Rodent studies indicate the ME and EE are potentially toxic compounds causing teratogenic, fetotoxic, hematotoxic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d225c602717b9fd7972b20c3e21fefa8
https://pubmed.ncbi.nlm.nih.gov/1397793
https://pubmed.ncbi.nlm.nih.gov/1397793