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Endogenous blockade of 1,25-dihydroxyvitamin D-receptor binding in New World primate cells

Autor: M A Gacad, J S Adams

Publikováno v: Journal of Clinical Investigation. 87:996-1001

When assessed by 1,25-dihydroxyvitamin D3 (1,25(OH)2-D3)-receptor (VDR) binding analysis or 1,25(OH)2-D3-VDR-directed bioresponsiveness, cultured cells from some New World primates (platyrrhines) demonstrate a variable decrement in VDR when compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a069b8ffdf45f8d9699ed318d46ae4
https://doi.org/10.1172/jci115108

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Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo

Autor: J S, Adams, H, Chen, R F, Chun, L, Nguyen, S, Wu, S Y, Ren, J, Barsony, M A, Gacad

Publikováno v: Journal of cellular biochemistry. 88(2)

We undertook an investigation of an outbreak of rachitic bone disease in the Emperor Tamarin New World primate colony at the Los Angeles Zoo in the mid-1980s. The disease phenotype resembled that observed in humans with an inactivating mutation of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37a59462b2632fe0f6f923ac6e20e2c7
https://pubmed.ncbi.nlm.nih.gov/12520531

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Vitamin D as a cytokine and hematopoetic factor

Autor: M, Hewison, M A, Gacad, J, Lemire, J S, Adams

Publikováno v: Reviews in endocrinemetabolic disorders. 2(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69cff40c1ea12b9b2990e8f26b96ca42
https://pubmed.ncbi.nlm.nih.gov/11705327

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Bone mineral density increases with vitamin D repletion in patients with coexistent vitamin D insufficiency and primary hyperparathyroidism

Autor: V, Kantorovich, M A, Gacad, L L, Seeger, J S, Adams

Publikováno v: The Journal of clinical endocrinology and metabolism. 85(10)

Two hundred and twenty-nine consecutive subjects, 202 women and 27 men, referred for evaluation of osteoporosis or low bone mineral density (BMD) had serum measurements of immunoreactive PTH (iPTH) and 25-hydroxyvitamin D (25OHD) performed. Fifteen i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d349d047134ba471b36de62afc369f97
https://pubmed.ncbi.nlm.nih.gov/11061498

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Proteins in the heat shock-70 family specifically bind 25-hydroxyvitamin D3 and 17beta-estradiol

Autor: M A, Gacad, J S, Adams

Publikováno v: The Journal of clinical endocrinology and metabolism. 83(4)

Most New World primates evolved to express a form of compensated resistance to steroid hormones from the gonads and adrenal glands as well as to the hydroxylated vitamin D3 prohormone, 25-hydroxyvitamin D3 (25OHD3), and the vitamin D hormone 1,25-dih

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0af8f76b93749303fa971d9163f5183e
https://pubmed.ncbi.nlm.nih.gov/9543154

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Functional characterization and purification of an intracellular vitamin D-binding protein in vitamin D-resistant new world primate cells. Amino acid sequence homology with proteins in the hsp-70 family

Autor: M A, Gacad, H, Chen, J E, Arbelle, T, LeBon, J S, Adams

Publikováno v: The Journal of biological chemistry. 272(13)

Most genera of New World primates exhibit resistance to vitamin D. These monkeys harbor high circulating concentrations of the prohormone 25-hydroxyvitamin D and the active vitamin D hormone 1, 25-dihydroxyvitamin D. Previous work from this laborator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0467e6ab8ac31b63a11c5b003760052
https://pubmed.ncbi.nlm.nih.gov/9079669

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Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis

Autor: J S Adams, M A Gacad

Publikováno v: The Journal of Experimental Medicine

We investigated the 1 alpha-hydroxylation of vitamin D3 sterols by cultured pulmonary alveolar macrophages (PAM) from patients with sarcoidosis with or without clinically abnormal calcium homeostasis. Like the naturally occurring renal 1 alpha-hydrox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ad8cd9a94465b02c76d3e854a48e5c
https://doi.org/10.1084/jem.161.4.755

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Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis

Autor: O P Sharma, Frederick R. Singer, John S. Adams, M A Gacad

Publikováno v: The Journal of clinical investigation. 72(5)

Metabolism of [3H]25-hydroxyvitamin D3(25-OH-D3) was studied in primary cultures of pulmonary alveolar macrophages (PAM) from seven patients with sarcoidosis and two patients with idiopathic pulmonary fibrosis. Production of a [3H]1,25-dihydroxyvitam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6389fcda3b6e3359ebecc398c2419b1
https://pubmed.ncbi.nlm.nih.gov/6688814

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Biochemical indicators of disordered vitamin D and calcium homeostasis in sarcoidosis

Autor: J S, Adams, M A, Gacad, A, Anders, D B, Endres, O P, Sharma

Publikováno v: Sarcoidosis. 3(1)

In an attempt to identify factors that may indicate which patients with sarcoidosis are likely to manifest a clinical abnormality in calcium homeostasis, we measured serum concentrations of calcium, angiotensin converting enzyme activity (ACE), 25-hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::550c34efe8bdf54aeaeedfbcd2253145
https://pubmed.ncbi.nlm.nih.gov/3033783

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