Výsledky vyhledávání - "M A, Dronina"

Study of Fibronectin Type III-Like Domains Role in Activation of gp130 Receptor

Autor: Alexey Stepanov, S. M. Deev, A. S. Rybinets, M. A. Dronina

Publikováno v: Bulletin of Experimental Biology and Medicine. 161:72-74

Chimeric gp130 receptors were produced to study the role of three fibronectin type III-like domains in activation of gp130 receptor machinery. The ligand-induced dimerization of gp130 was sufficient to trigger STAT3 signaling pathway. These findings

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d296dacf0e957fd82112f8a3977eecf
https://doi.org/10.1007/s10517-016-3348-8

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Evolution of inhibitor-resistant natural mutant forms of HIV-1 protease probed by pre-steady state kinetic analysis

Autor: Alexandra A. Kuznetsova, A. V. Kozyr, Alexander V. Kolesnikov, E. N. Kaliberda, Alexander G. Gabibov, Maria Yu. Zakharova, Dmitry G. Knorre, Nikita A. Kuznetsov, Olga S. Fedorova, M. A. Dronina, Lev D. Rumsh, Ivan V. Smirnov

Publikováno v: Biochimie. 142

Pre-steady state kinetic analysis of mechanistic features of substrate binding and processing is crucial for insight into the evolution of inhibitor-resistant forms of HIV-1 protease. These data may provide a correct vector for rational drug design a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c250a0c9e3106700a84734babb3f1b
https://pubmed.ncbi.nlm.nih.gov/28843613

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Polyreactive Monoclonal Autoantibodies in Multiple Sclerosis: Functional Selection from Phage Display Library and Characterization by Deep Sequencing Analysis

Autor: A. E. Tupikin, Alexey A. Belogurov, Alexander G. Gabibov, Alexander V. Favorov, Marsel R. Kabilov, Yakov A. Lomakin, Aleksey Nikolaevich Boyko, M. Yu. Zakharova, Nadia Bykova, M. A. Dronina, V. D. Knorre, N. A. Ponomarenko

Publikováno v: Acta Naturae. 5:94-104

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system that primarily affects young and middle-aged people. It is widely accepted that B lymphocyte activation is required for MS progression. Despite the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe1b2b69187e3fa17357cf92efb640df
https://doi.org/10.32607/20758251-2013-5-4-94-104

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Expression of catalytic antibodies in eukaryotic systems

Autor: T. V. Bobik, A. V. Kaznacheeva, Alexey A. Belogurov, Alexander G. Gabibov, A. V. Zakharov, Ivan V. Smirnov, I. N. Kurkova, Marina V. Serebryakova, Natalia A. Ponomarenko, M. A. Dronina, Alain Friboulet

Publikováno v: Molecular Biology. 45:74-81

Expression of recombinant antibodies in mammalian cells is one of the key problems in immuno-biotechnology. Alternatively, expression of a broad panel of antibodies and of their fragments may be effectively performed in yeast cells. We obtained expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::def08d415e21af0a61af9889716bfbad
https://doi.org/10.1134/s0026893311010171

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Development of a recombinant immunotoxin for the immunotherapy of autoreactive lymphocytes expressing MOG-specific BCRs

Autor: Alexander G. Tonevitsky, N. A. Ponomarenko, Igor E. Kasheverov, D. A. Sakharov, Alexey A. Belogurov, Alexey Stepanov, Alexander Belyy, Alexandra Rybinets, Victor I. Tsetlin, Igor A. Dyachenko, Alexander G. Gabibov, Arkady N. Murashev, M. A. Dronina, V. D. Knorre, Sergey M. Deyev

Publikováno v: Biotechnology letters. 38(7)

Myelin oligodendrocyte glycoprotein (MOG) is one of the major autoantigens in multiple sclerosis (MS), therefore selective depletion of autoreactive lymphocytes exposing MOG-specific B cell receptors (BCRs) would be beneficial in terms of MS treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdbcab43e73359192ea1ada146a23c9
https://pubmed.ncbi.nlm.nih.gov/27099070

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Heavy-light chain interrelations of MS-associated immunoglobulins probed by deep sequencing and rational variation

Publikováno v: Molecular immunology. 62(2)

The mechanisms triggering most of autoimmune diseases are still obscure. Autoreactive B cells play a crucial role in the development of such pathologies and, in particular, production of autoantibodies of different specificities. The combination of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b3c79d287c08e43b7321266a2a9e47
https://pubmed.ncbi.nlm.nih.gov/24534716

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Pre-steady-state kinetics of interaction of wild-type and multiple drug-resistant HIV protease with first and second generation inhibitory drugs

Autor: Nikita A. Kuznetsov, Alexander G. Gabibov, Alexander V. Kolesnikov, Ivan V. Smirnov, A. G. Mikhailova, Olga S. Fedorova, Lev D. Rumsh, A. V. Kozyr, E. N. Kaliberda, M. A. Dronina

Publikováno v: Doklady. Biochemistry and biophysics. 440

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https://pubmed.ncbi.nlm.nih.gov/22095129

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[Expression of the catalytic antibodies in eukaryotic systems]

Autor: A V, Zakharov, I V, Smirnov, M V, Serebriakova, M A, Dronina, A V, Kaznacheeva, I N, Kurkova, A A, Belogurov, A, Friboulet, N A, Ponomarenko, A G, Gabibov, T V, Bobik

Publikováno v: Molekuliarnaia biologiia. 45(1)

Expression of recombinant antibodies in mammalian cells is one of key problems in immunobiotechnology. Alternatively, expression of a broad panel of antibodies and of their fragments may be effectively done in yeast cells. We obtained expression stra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f0985c4b04e8ed7cc02b4dbba18f79b
https://pubmed.ncbi.nlm.nih.gov/21485500

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Toxin-binding proteins from midgut epithelium membranes of Anopheles stephensi larvae

Autor: L. P. Revina, L. A. Ganushkina, M. A. Dronina, Galina G. Chestukhina, L. I. Kostina, Zalunin Ia

Publikováno v: Biochemistry. Biokhimiia. 71(2)

Proteins of 65 and 57 kD were isolated from the apical membranes of midgut epithelium of Anopheles stephensi larvae by affinity chromatography. These proteins can specifically bind endotoxin Cry11A and activate toxin Cry4B (Cry4B-tox) under condition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455b99355a0e3d681f17996b8b550642
https://pubmed.ncbi.nlm.nih.gov/16489916

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[Cytopathological effect of Bacillus thuringiensis israelensis endotoxins on the intestines of Aedes aegypti mosquito larvae]

Autor: I A, Zalunin, S Iu, Chaĭka, M A, Dronina, L P, Revina

Publikováno v: Parazitologiia. 36(5)

The dynamics of pathological changes in the intestine of Aedes aegypti larvae under the influence of toxins Cry11A and Cry4B produced by Bacillus thuringiensis israelensis was studied by means of electron microscope. Most significant ultrastructure c

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https://pubmed.ncbi.nlm.nih.gov/12481602

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