Zobrazeno 1 - 10 of 13 pro vyhledávání: '"M A, Ator"'
1
lnterleukin-1β Converting Enzyme: Biology and the Chemistry of Inhibitors
Autor: R. E. Dolle, M. A. Ator
Publikováno v: Current Pharmaceutical Design. 1:191-210
Interleukin-1β converting enzyme (ICE) catalyzes processing of biologically inactive pro IL-1β to mature II-1β. IL-1β is implicated in the pathogenesis of a number of inflammatory diseases, suggesting that compounds which inhibit ICE and reduce l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f00df8d56451a6c4cee4b98bb2a71a2d
https://doi.org/10.2174/1381612801666220917220634
Zobrazit plný text záznamu
2
Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1 beta converting enzyme
Autor: B E Miller, P A Krasney, D M Gauvin, K B Holbrook, D J Koonz, R V Abruzzese, R E Miller, K A Pagani, R E Dolle, M A Ator
Publikováno v: The Journal of Immunology. 154:1331-1338
The proinflammatory cytokine IL-1 beta is synthesized by activated monocytes and macrophages as a 31-kDa, biologically inactive precursor that is proteolytically processed to the biologically active 17-kDa mature molecule by the IL-1 beta converting
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94d7dede5a6fe30a7ee3c93ecb165c9d
https://doi.org/10.4049/jimmunol.154.3.1331
Zobrazit plný text záznamu
4
Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1 beta converting enzyme
Autor: B E, Miller, P A, Krasney, D M, Gauvin, K B, Holbrook, D J, Koonz, R V, Abruzzese, R E, Miller, K A, Pagani, R E, Dolle, M A, Ator
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 154(3)
The proinflammatory cytokine IL-1 beta is synthesized by activated monocytes and macrophages as a 31-kDa, biologically inactive precursor that is proteolytically processed to the biologically active 17-kDa mature molecule by the IL-1 beta converting
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c99c548079d82a35cc5c33bc43dfd37
https://pubmed.ncbi.nlm.nih.gov/7822802
Zobrazit plný text záznamu
6
Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin-1 beta converting enzyme (ICE)
Autor: T L, Graybill, R E, Dolle, C T, Helaszek, R E, Miller, M A, Ator
Publikováno v: International journal of peptide and protein research. 44(2)
Aspartyl aldehyde, Ac-Tyr-Val-Ala-Asp-H 1 (L-709,049), has been reported to be a potent, reversible inhibitor of interleukin-1 beta converting enzyme (ICE) [Thornberry, N.A. et al. (1992) Nature (London) 356, 768-774]. In the context of our own work,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5aa7ba5956c3e8c61811fdace07b9afc
https://pubmed.ncbi.nlm.nih.gov/7982761
Zobrazit plný text záznamu
8
Mechanism of ribonucleotide reductase from herpes simplex virus type 1. Evidence for 3' carbon-hydrogen bond cleavage and inactivation by nucleotide analogs
Autor: J. A. Stubbe, M. A. Ator, T. Spector
Publikováno v: Journal of Biological Chemistry. 261:3595-3599
Isotope effects of 2.5, 2.1, and 1.0 were measured on the conversion of [3'-3H]ADP, [3'-H]UDP, and [5-3H] UDP to the corresponding 2'-deoxynucleotides by herpes simplex virus type 1 ribonucleotide reductase. These results indicate that the reduction
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e136114db2334638f8505225b4e81f8b
https://doi.org/10.1016/s0021-9258(17)35688-0
Zobrazit plný text záznamu
9
Structure and catalytic mechanism of horseradish peroxidase. Regiospecific meso alkylation of the prosthetic heme group by alkylhydrazines
Autor: P R Ortiz de Montellano, S K David, M A Ator
Publikováno v: Journal of Biological Chemistry. 262:14954-14960
Horseradish peroxidase is inactivated in a time-, H2O2-, and concentration-dependent manner by phenylethyl-, ethyl-, and methylhydrazine. The pseudo- first order kinetic constants for these inactivation reactions at pH 7 are: phenylethyl (KI = 115 mi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::218eb773d1323374f1431e7125bef3d2
https://doi.org/10.1016/s0021-9258(18)48121-5
Zobrazit plný text záznamu
10
Protein control of prosthetic heme reactivity. Reaction of substrates with the heme edge of horseradish peroxidase
Autor: M A, Ator, P R, Ortiz de Montellano
Publikováno v: The Journal of biological chemistry. 262(4)
Incubation of horseradish peroxidase with phenylhydrazine and H2O2 markedly depresses the catalytic activity and the intensity, but not position, of the Soret band. Approximately 11-13 mol of phenylhydrazine and 25 mol of H2O2 are required per mol of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37528fbe26e4d0f9a61ce7c3a998d918
https://pubmed.ncbi.nlm.nih.gov/3805041
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje