Zobrazeno 1 - 10
of 2 639
pro vyhledávání: '"M Donnelly"'
Autor:
Nicholas H. Stillman, Johnson A. Joseph, Jemil Ahmed, Charles Zuwu Baysah, Ryan A. Dohoney, Tyler D. Ball, Alexandra G. Thomas, Tessa C. Fitch, Courtney M. Donnelly, Sunil Kumar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Abberent protein-protein interactions potentiate many diseases and one example is the toxic, self-assembly of α-Synuclein in the dopaminergic neurons of patients with Parkinson’s disease; therefore, a potential therapeutic strategy is the
Externí odkaz:
https://doaj.org/article/33653df251db405bb66003cb7c1cf223
Autor:
Alexandra E. Perlegos, Xiuming Quan, Kirby M. Donnelly, Hui Shen, Emily J. Shields, Heidi Elashal, Kathy Fange Liu, Nancy M. Bonini
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Chronic cellular stress has a profound impact on the brain, leading to degeneration and accelerated aging. Recent work has revealed the vital role of RNA modifications, and the proteins responsible for regulating them, in the stress response
Externí odkaz:
https://doaj.org/article/7872d98e70d44b018bf69a5a8af00fcd
Autor:
Kari Bø, Isabel S Moore, Patrick O'Halloran, Joanna Perkins, Gráinne M Donnelly, Mairéad Liston, Molly McCarthy-Ryan, Karina Leahy, Yeomans Caithriona
Publikováno v:
BMJ Open Sport & Exercise Medicine, Vol 10, Iss 1 (2024)
Objectives Female athletes engaging in high-impact sports have a higher prevalence of experiencing stress urinary incontinence (SUI). However, the prevalence of sport-specific SUI and associated risk factors in female rugby players is relatively unkn
Externí odkaz:
https://doaj.org/article/23e36446402b4738bff4747418729f3c
Autor:
Brianna M. Donnelly, David T. Hsu, John Gardus, Junying Wang, Jie Yang, Ramin V. Parsey, Christine DeLorenzo
Publikováno v:
NeuroImage: Clinical, Vol 41, Iss , Pp 103553- (2024)
Background: Social anhedonia is common within major depressive disorder (MDD) and associated with worse treatment outcomes. The orbitofrontal cortex (OFC) is implicated in both reward (medial OFC) and punishment (lateral OFC) in social decision makin
Externí odkaz:
https://doaj.org/article/780951da789f44078726c6b0a0d98887
Autor:
Hongwen Chen, Xiaofeng Qi, Rebecca A. Faulkner, Marc M. Schumacher, Linda M. Donnelly, Russell A. DeBose-Boyd, Xiaochun Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
HMG-CoA reductase (HMGCR) is regulated by UBIAD1 and Insigs and initializes cholesterol synthesis. Here authors show that the sterol sensing domain of HMGCR undergoes conformational changes to regulate its degradation via binding its protein modulato
Externí odkaz:
https://doaj.org/article/4a056b4f7f0d479aaf606c0207088a37
Autor:
Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, Johnson A. Joseph, Tyler D. Ball, Mikaela M. Bassil, Ahyun Son, Chen Zhang, Aurélie Ledreux, Scott Horowitz, Yan Qin, Daniel Paredes, Sunil Kumar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Inhibiting alpha-synuclein self-assembly into amyloid structures, associated with Parkinson’s disease, is a potential therapeutic intervention. Here, the authors identify the domains/sequences that are essential for alpha-synuclein aggregation and
Externí odkaz:
https://doaj.org/article/90b6ab61face4e2e9229b5bec4e05f95
Publikováno v:
Viruses, Vol 16, Iss 1, p 33 (2023)
Australian bat lyssavirus (ABLV) shows similar clinical symptoms as rabies, but there are currently no protein structures available for ABLV proteins. In lyssaviruses, the interaction between nucleoprotein (N) and phosphoprotein (N) in the absence of
Externí odkaz:
https://doaj.org/article/d851787a4b774ba998007d7926d7995b
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Shuttling of macromolecules between nucleus and cytoplasm is a tightly regulated process mediated through specific interactions between cargo and nuclear transport proteins. In the classical nuclear import pathway, importin alpha recognizes
Externí odkaz:
https://doaj.org/article/127e161707ad4eb6a7e69278c9208aae
Autor:
Cathleen C. Kuo, Alexander O. Aguirre, Andrea Kassay, Brianna M. Donnelly, Hebatalla Bakr, Mohamed Aly, Ahmed A.M. Ezzat, Mohamed A.R. Soliman
Publikováno v:
Scientific African, Vol 19, Iss , Pp e01504- (2023)
Background: The COVID-19 pandemic has left an indelible effect on healthcare delivery and education system, including residency training. Particularly, neurosurgical departments worldwide had to adapt their operating model to the constantly changing
Externí odkaz:
https://doaj.org/article/99cddd6e65504151a9584c0a62056371
Autor:
Kirby M. Donnelly, Cevannah M. Coleman, Madison L. Fuller, Victoria L. Reed, Dayna Smerina, David S. Tomlinson, Margaret M. Panning Pearce
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The hypothesis that pathogenic protein aggregates associated with neurodegenerative diseases spread from cell-to-cell in the brain in a manner akin to infectious prions has gained substantial momentum due to an explosion of research in the past 10–
Externí odkaz:
https://doaj.org/article/0641091592684ffc81562a7a343ee777