Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity.

Autor: Yoshiji S; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Department of Human Genetics, McGill University, Montréal, Quebec, Canada.; Kyoto-McGill International Collaborative Program in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Japan Society for the Promotion of Science, Tokyo, Japan., Butler-Laporte G; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada., Lu T; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Quantitative Life Sciences Program, McGill University, Montréal, Quebec, Canada.; 5 Prime Sciences, Montréal, Quebec, Canada., Willett JDS; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Quantitative Life Sciences Program, McGill University, Montréal, Quebec, Canada., Su CY; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Department of Computer Science, McGill University, Montréal, Quebec, Canada., Nakanishi T; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Department of Human Genetics, McGill University, Montréal, Quebec, Canada.; Kyoto-McGill International Collaborative Program in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Japan Society for the Promotion of Science, Tokyo, Japan., Morrison DR; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Chen Y; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Department of Human Genetics, McGill University, Montréal, Quebec, Canada., Liang K; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Quantitative Life Sciences Program, McGill University, Montréal, Quebec, Canada., Hultström M; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada.; Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.; Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Ilboudo Y; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Afrasiabi Z; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Lan S; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Duggan N; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., DeLuca C; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Vaezi M; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Tselios C; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Xue X; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Bouab M; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Shi F; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Laurent L; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Münter HM; McGill Genome Centre, McGill University, Montréal, Quebec, Canada., Afilalo M; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Department of Emergency Medicine, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Afilalo J; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada.; Division of Cardiology, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Mooser V; Department of Human Genetics, McGill University, Montréal, Quebec, Canada.; McGill Genome Centre, McGill University, Montréal, Quebec, Canada., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Zeberg H; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany., Zhou S; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; Department of Human Genetics, McGill University, Montréal, Quebec, Canada.; McGill Genome Centre, McGill University, Montréal, Quebec, Canada., Forgetta V; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.; 5 Prime Sciences, Montréal, Quebec, Canada., Farjoun Y; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada., Richards JB; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada. brent.richards@mcgill.ca.; Department of Human Genetics, McGill University, Montréal, Quebec, Canada. brent.richards@mcgill.ca.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada. brent.richards@mcgill.ca.; 5 Prime Sciences, Montréal, Quebec, Canada. brent.richards@mcgill.ca.; Department of Twin Research, King's College London, London, UK. brent.richards@mcgill.ca.

Publikováno v: Nature metabolism [Nat Metab] 2023 Feb; Vol. 5 (2), pp. 248-264. Date of Electronic Publication: 2023 Feb 20.